Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
Get full text

Crack densification in drying colloidal suspensions by Lilin, Paul, Ibrahim, Mario, Bischofberger, Irmgard

“…We show that the final spacing between radial cracks is proportional to the local thickness of the deposit, while the aspect ratio of the crack segments depends on the shape of the deposit.…”
Get full text

Spin carbon nanotubes into CNT fibers by Lim, Johnathan See Kwan.

“…After densifying, each strand of fiber were tested for their mechanical properties before they were divided into smaller segments and twisted together to form multi-ply fibers, ranging from a 2 ply CNT yarn to a 10 ply CNT yarn. …”
Get full text

Multi-linear regression models for traffic prediction in large-scale networks by Zhao, XinYue

“…Various methods have been practice in the traffic forecasting study and some algorithms that used in other fields like In this paper we apply 3 multi-linear regression models on the speed data collected from 266 road segments in Singapore, which are Partial Least Square, High-Order Partial Least Square and N-way Partial Least Square model. …”
Get full text

National Day parades : we the citizens of Singapore by Low, Annabel Hui Xin

“…This will be done through the examination of how three segments of the National Day parade – the military showcase, performances and National Day songs – have been used and adapted over the years to further the government’s nation building efforts in Singapore.…”
Get full text

Development of a mooring line model for coupled floating structure dynamic analysis by Bai, Ziyi

“…The model should possess the features of adding point buoys, clump weights, different anchor fairlead concepts and multiple line segments to a single mooring line. The model is proposed by National Renewable Energy Laboratory, U.S. as multi-segmented quasi-static modelling. …”
Get full text

Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits by Hu, S, Ferreira, LAF, Shi, S, Hellenthal, G, Marchini, J, Lawson, DJ, Myers, SR

“…To estimate the similarity of genetic effect sizes between groups, we developed ANCHOR, which estimates changes in the predictive power of an existing PGS in distinct local ancestry segments. ANCHOR infers highly similar (estimated correlation 0.98 ± 0.07) effect sizes between UK Biobank participants of African and European ancestry for 47 of 53 quantitative phenotypes, suggesting that gene–environment and gene–gene interactions do not play major roles in poor cross-ancestry PGS transferability for these traits in the United Kingdom, and providing optimism that shared causal mutations operate similarly in different populations.…”

Instabilities in tidal turbine wakes by Smyth, ASM, Nishino, T, Young, AM

“…Unsteady inflow causes the turbine blades to shed vorticity of time-varying strength into the wake, which in turn leads to a spatial variation in wake vortex strength, such that the vorticity of adjacent returning wake segments can differ. This spatial variation triggers the instability of tip vortices, the characteristics of which are shown to be governed by the ’frequency ratio’ ω/ΩNB (where ω is harmonic inflow frequency, Ω is turbine rotational frequency and NB is the number of blades). …”

Antiretroviral therapy optimisation without genotype resistance testing : a perspective on treatment history based models by Prosperi, Mattia C. F., Sloot, Peter M. A., van de Vijver, David A. M. C., Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Schülter, Eugen, Struck, Daniel, Di Giambenedetto, Simona, Kaiser, Rolf, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Sensitivity analyses, carried out on a data subset that included antiretroviral regimens commonly used in low to middle income countries, confirmed our findings. …”
Get full text
Get full text

Deadweight costs and optimal capital structure. by Liang, Huijun., Lim, Wei Ling.

“…Banerjee and Noe (2010) shows that MNCs do not necessarily obtain all of their financing in locations that feature the most creditor friendly legal regime. In this paper, our model is consistent with those empirical findings. …”
Get full text

Drag of generic round-shaped bodies in supersonic flow by Song, Dennis Shao Hui.

“…The various drag components were analysed over a supersonic regime between the Mach numbers 1.5 to 4 at sea level while the effects of geometry variations were investigated. …”
Get full text

Glass transition behaviour In a voronoi model of cell tissues by Loh, Leon Yeong Wei

“…This allows one to study the static and dynamical statistical properties in the temperature regime where mode-coupling theory is dominant. Both the dynamic and hexatic correlation lengths are found to have a negative relation with temperature. …”
Get full text

Beam studies using a Cherenkov diffraction based beam position monitor for AWAKE by Spear, B, Burrows, PN, Pakuza, C, Senes, E, Mazzoni, S, Lefevre, T, Wendt, M

“…Furthermore, high frequency studies investigating the proton bunch spectrum show that a much higher frequency regime is needed to exclude the proton signal than previously expected.…”

Working for two bosses: Student interns as constrained labour in China by Smith, C, Chan, J

“…Thus, within such an unfree labour regime, student workers are subject to dual control in the workplace from managerial and teacher-supervisors.…”

Marital instability in the context of dramatic societal change : the case of Kyrgyzstan by Dommaraju, Premchand, Agadjanian, Victor

“…Using detailed and rich data from Kyrgyzstan, the study investigates trends over time in marital instability in response to societal upheavals and gradual secular transformations; ethnic group-specific responses in marital instability; and the role of changing gender regimes in marital instability. The findings reveal an increase in the rate of marital dissolution over time. …”
Get full text
Get full text
Get full text

On a submerged wave energy converter with snap-through power take-off by Wang, Lixian, Tang, Hui, Wu, Yanhua

“…With larger waves impacting on the WEC, the conversion efficiency of the present nonlinear PTO increases significantly. Three response regimes, i.e. local oscillation, aperiodic snap-through, and periodic snap-through, of the nonlinear PTO system are observed with various wave amplitudes. …”
Get full text

Non-Markovian refrigeration and heat flow in the quantum switch by Cheong, Jian Wei, Pradana, Andri, Chew, Lock Yue

“…In particular, we compare the quantum switch to the superposition of independent channels where two quantum channels are placed in a superposition, which have no non-Markovian effects, and show that the quantum switch can only outperform the superposition of independent channels in the prethermalization regimes, which also depends on the presence and amount of non-Markovianity. …”
Get full text

Laboratory realization of relativistic pair-plasma beams by Arrowsmith, C, Simon, P, Bilbao, P, Bott, A, Burger, S, Chen, H, Cruz, F, Davenne, T, Efthymiopoulos, I, Froula, D, Goillot, AM, Gudmundsson, JT, Haberberger, D, Halliday, J, Hodge, T, Huffman, B, Iaquinta, S, Miniati, F, Reville, B, Sarkar, S, Schekochihin, A, Silva, L, Simpson, Stergiou, V, Trines, R, Vieu, T, Charitonidis, N, Bingham, R, Gregori, G

“…Our work opens up the possibility of directly probing the microphysics of pair plasmas beyond quasi-linear evolution into regimes that are challenging to simulate or measure via astronomical observations. …”

Comparison of Machine Learning-Based Methods for Narrowband Blind Adaptive Beamforming by Shonkwiler, Lara

“…Machine learningbased methods are of interest because they show promise in low sample support regimes, and because they offer the possibility of a ‘one size fits all’ solution that can adaptively recognize and exploit different signal features. …”
Get full text

Irreverence intended? Destabilizing ‘intent’ as determinative in discourse around satire at the ECtHR by Hussain, H, Sanghi, S

“…By interpreting legal discourse around satire at the ECtHR and interrogating the suitability of prevalent tests and defences pertaining to satirical expressions, we advocate for the emergence of a shared framework within humour regimes to facilitate a relatively better communal understanding of satire and its permissible limits. …”