Multi-Proxy Records of Climate and Carbon Cycle Perturbations in the Paleozoic: Integrating Isotope Geochemistry and Sedimentology by Anderson, Noah

“…To glean robust information from this archive, we must understand how carbonate sediments form, ensure our analytical techniques are optimized, and consider how inherently local deposition of sediments can communicate information about global changes in climate. …”
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Advancing the chemotherapy of tuberculous meningitis: a consensus view by Wasserman, S, Donovan, J, Kestelyn, E, Watson, JA, Aarnoutse, RE, Barnacle, JR, Boulware, DR, Chow, FC, Cresswell, FV, Davis, AG, Dooley, KE, Figaji, AA, Gibb, DM, Huynh, J, Imran, D, Marais, S, Meya, DB, Misra, UK, Modi, M, Raberahona, M, Ganiem, AR, Rohlwink, UK, Ruslami, R, Seddon, JA, Skolimowska, KH, Solomons, RS, Stek, CJ, Thuong, NTT, van Crevel, R, Whitaker, C, Thwaites, GE, Wilkinson, RJ

“…Antimicrobial treatment is based on regimens used for pulmonary tuberculosis, which overlooks important differences between lung and brain drug distributions. …”

Comparison between CaO- and MgO-activated ground granulated blast-furnace slag (GGBS) for stabilization/solidification of Zn-contaminated clay slurry by Zhang, Yunhui, Ong, Yi Jie, Yi, Yaolin

“…Stabilization/solidification (S/S) is a low-cost and effective remedial technique for dredged contaminated sediments. Quick lime (CaO)-activated and reactive magnesia (MgO)-activated ground granulated blast furnace slag (GGBS) are effective and low-carbon S/S binders. …”
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Determining targets for antiretroviral drug concentrations: a causal framework illustrated with pediatric efavirenz data from the CHAPAS-3 trial by Schomaker, M, Denti, P, Bienczak, A, Burger, D, Díaz, I, Gibb, DM, Walker, AS, McIlleron, H

“…<p><strong>Background:&nbsp;</strong>Determining a therapeutic window for maintaining antiretroviral drug concentrations within an appropriate range is required for identifying effective dosing regimens. The limits of this window are typically calculated using predictive models. …”

Heavy metals distribution in mangrove leaves in various sudanese coastal zones at the red sea by Mohammad Khalil, Rabha Khalil, Solangi, Kashif Ali, Alhassan, Abdullahi Bala, Khan, Waseem Razzaq, Aljahdali, Mohammed Othman

“…The heavy metal accumulation typical of a mangrove species, Avicenna marina L.,(A. marina) leaves and soluble salts in sediments have not been studied on the Red Sea coast of Sudan. …”
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Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…Incorporating core strength training into regular regimens can improve athletes' overall strength, endurance, balance, control, and prevent injuries. …”
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3D confined jet scour at a wall by Chee, Wei Hong

“…Scouring is a natural phenomenon of sediment transportation caused by the lifting and reposition of sediments by strong current or rapid flowing water. …”
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Characterisation of novel electroactive consortia from environmental samples enriched through potentiostatic growth by Doyle, Lucinda Elizabeth

“…Comparison revealed the enriched community from canal sediment was superior to that from the mangrove sediment in terms of electrogenic activity when evaluated by chronoamperometry, and was chosen for further characterisation. …”
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Treatment options to support the elimination of Hepatitis C: an open label, factorial randomised controlled trial by Cooke, G, Le Manh, H, Flower, B, McCabe, L, Vu Thu Kim, H, Vo Thi, T, Dang Trong, T, Nguyen Thanh, D, Le Thanh, P, Dao Bach, K, Nguyen Thi Chau, A, Pham Ngoc, T, Vu Thu Thu, H, Dang Thi, B, Nguyen Kim, T, Ansari, A, Le Ngoc, C, Vo Minh, Q, Nguyen Thi Ngoc, P, Le Thi, T, Nguyen Bao, T, Kestelyn, E, Kingsley, C, Van Doorn, R, Rahman, M, Pett, S, Thwaites, G, Barnes, E, Day, J, Nguyen Van Vinh, C, Walker, AS

“…No randomised trials have compared these regimens and high cure rates may be achievable with shorter durations of therapy.…”

Drug interaction between acetyltanshinone IIA and rapamycin in breast cancer cells by Wong, De Pin

“…Developing in vitro drug combination study is essential for the development of new and effective combination regimens. In this project, the objective is to investigate the synergistic potential between two anti breast cancer agent, rapamycin and acetyltanshinone IIA (ATA) in breast cancer cells. …”
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Sequential phreatomagmatic eruptions during the lateral propagation of giant dyke swarms by Pryce, E, Cartwright, J, Kirkham, C, Phillips, D

“…Craters are flanked by a tephra apron comprising reworked chalky sediments. The well data allow us to exclude crater forming mechanisms based on collapse into a void, but are consistent with those linked to phreatomagmatic eruption. …”

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Further, to augment efficacy, combination regimens were also explored. Results We confirm that only ACK2 inhibits SCF binding fully and prevents HSC proliferation in vitro. …”
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The role of SPRTN protease in colorectal cancer chemotherapy by Peron, C

“…The first-line treatment of metastatic colorectal cancer (mCRC) is frequently based on combination chemotherapeutic regimens, where 5-fluorouracil is either associated with irinotecan (FOLFIRI) or oxaliplatin (FOLFOX). …”

Shedding Light on Chemoresistance: The Perspective of Photodynamic Therapy in Cancer Management by Viana Cabral, Fernanda, Quilez Alburquerque, Jose, Roberts, Harrison James, Hasan, Tayyaba

“…Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance in cancer regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility to subsequent therapies. …”
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Numerical modeling of the influence of scour and scour protection on monopile dynamic behavior by Mayall, RO, Burd, HJ, McAdam, RA, Byrne, BW, Whitehouse, RJS, Heald, SG, Slater, PL

“…Scour of seabed sediments can occur around offshore foundations. For monopile-supported offshore wind turbine structures, the reduction in foundation stiffness due to scour presents certain operational challenges. …”

Disposition kinetics of tylosin administered intravenously and intramuscularly in Desert Sheep and Nubian Goats by Taha, A.A., Elsheikh, H.A., Khalafalla, A.E., Osman, I. A. M., Abdullah, A. Salam

“…The present study has shown that, despite the significant differences in some of the drug pharmacokinetic parameters between sheep and goats for the i.v. route, identical intravenous and intramuscular dosage regimens of tylosin may be recommended for the two species.…”
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In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. …”
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Transformation by-product identification from oxidation processes of waters containing model organic micropollutants (Nonylphenol) by Toh, Jewell Zi Le

“…Nonylphenol accumulates in environmental matrices with high organic content, such as sewage sludge, river works, and sediments, and persists in soil and groundwater due to its physical-chemical features, such as poor solubility and high hydrophobicity, hence it should be removed through water disinfection before consumption. …”
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Behind every domain there is a shift: adapting distortion-aware vision transformers for panoramic semantic segmentation by Zhang, J, Yang, K, Shi, H, ReiB, S, Peng, K, Ma, C, Fu, H, Torr, PHS, Wang, K, Stiefelhagen, R

“…Extensive experiments are conducted, which cover indoor and outdoor scenarios, and each of them is investigated with Pin2Pan and Syn2Real regimens. Trans4PASS+ achieves state-of-the-art performances on four domain adaptive panoramic semantic segmentation benchmarks. …”

Knowledge and practice regarding medication use among elderly with chronic diseases in Felda Tembangau 2, Kemayan, Pahang by Farid, Aina Natasha Mohd

“…The elderly population, defined as those aged 60 and above, faces unique challenges in managing chronic diseases due to physiological changes, limited access to healthcare information, and barriers in understanding and adhering to medication regimens. The aim of this study was to determine the levels of knowledge and practice regarding medication use among elderly with chronic diseases in FELDA Tembangau 2, Kemayan, Pahang and to explore the correlation between these two variables. …”
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