In Vivo RNA Delivery to Hematopoietic Stem and Progenitor Cells via Targeted Lipid Nanoparticles by Shi, Dennis, Toyonaga, Sho, Anderson, Daniel G

“…However, these therapies have several limitations owing to the manufacturing complexities and toxicity resulting from required conditioning regimens. Here, we developed a c-kit (CD117) antibody-targeted lipid nanoparticle (LNP) that, following a single intravenous injection, can deliver RNA (both siRNA and mRNA) to HSCs in vivo in rodents. …”
Get full text

Maxwell-type models for the effective thermal conductivity of a porous material with radiative transfer in the voids by Kiradjiev, KB, Halvorsen, SA, Van Gorder, RA, Howison, SD

“…In the high-temperature regime, radiative transfer within voids strongly influences the thermal conductivity of the bulk material. …”

Behind every domain there is a shift: adapting distortion-aware vision transformers for panoramic semantic segmentation by Zhang, J, Yang, K, Shi, H, ReiB, S, Peng, K, Ma, C, Fu, H, Torr, PHS, Wang, K, Stiefelhagen, R

“…Extensive experiments are conducted, which cover indoor and outdoor scenarios, and each of them is investigated with Pin2Pan and Syn2Real regimens. Trans4PASS+ achieves state-of-the-art performances on four domain adaptive panoramic semantic segmentation benchmarks. …”

Knowledge and practice regarding medication use among elderly with chronic diseases in Felda Tembangau 2, Kemayan, Pahang by Farid, Aina Natasha Mohd

“…The elderly population, defined as those aged 60 and above, faces unique challenges in managing chronic diseases due to physiological changes, limited access to healthcare information, and barriers in understanding and adhering to medication regimens. The aim of this study was to determine the levels of knowledge and practice regarding medication use among elderly with chronic diseases in FELDA Tembangau 2, Kemayan, Pahang and to explore the correlation between these two variables. …”
Get full text

Myanmar in Eu-Asean relations by Magnus Petersson

“…A rather skeptical view is emphasized on the ‘ASEAN Way’ in dealing with the military regime, and for the overall political dialogue with the European Union.…”
Get full text

Hollow microcapsules as periocular drug depot for sustained release of anti-VEGF protein by Radhakrishnan, Krishna, Vincent, Anita, Joseph, Rini Rachel, Moreno, Miguel, Dickescheid, Andreas, Agrawal, Rupesh, Venkatraman, Subbu S.

“…The current treatment regimen for such diseases involves repeated intravitreal injections of anti- Vascular Endothelial Growth Factor (VEGF) proteins. …”
Get full text

Elucidating the role of metabolic changes in modulating cell fate following treatment with anti-mitotic drugs by Wong, Alex Xing Fah

“…Better understanding of the cellular pathways underlying this escape from antimitotic drug-induced cell death, known as mitotic slippage, is crucial for development of combinatorial therapies that can enhance existing treatment regimen in patients. Mitotic slippage describes a phenomenon where cells escape mitotic arrest and cell death following treatment with anti-mitotic drugs, and "slip" into interphase without proper chromosome segregation and cytokinesis. …”
Get full text
Get full text

Evaluating new malaria vaccine candidates by Noé, A

“…Liver-resident memory CD8+ T cells (TRM) are necessary for protection against rodent malaria by this vaccine regimen. Ultimately, to most faithfully assess immunological responses by these local, specialised, hepatic T cells, periodic liver sampling is necessary. …”

Topological effects on the magnetoconductivity in topological insulators by Sacksteder, Vincent E., Arnardottir, Kristin Bjorg, Kettemann, Stefan, Shelykh, Ivan A.

“…In this wrapped regime the magnetoconductivity's dependence on temperature, typically 1/T2 in 2-DEGs, disappears. …”
Get full text
Get full text

Stress evolution of GaN/AlN heterostructure grown on 6H-SiC substrate by plasma assisted molecular beam epitaxy by Agrawal, Manvi, Ravikiran, Lingaparthi, Dharmarasu, Nethaji, Radhakrishnan, K., Karthikeyan, Giri Sadasivam, Zheng, Yuanjin

“…GaN/AlN structure is found to form buried cracks when AlN is grown in the intermediate growth regime(III/V∼1)and GaN is grown under N-rich growth regime (III/V<1). …”
Get full text
Get full text

Stabilization/solidification of Mn-contaminated clay slurry by using CaO-GGBS: effects of anions by Li, Wentao, Yi, Yaolin

“…Clay sediment is removed by dredging, resulting in the disposal of enormous waste sediment clay slurries that consumes land space, as well as risks the human health and the environment. …”
Get full text

Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…This trial showed that this regime was safe, well tolerated and did not result in any immunological interference. …”

The prevention and management of chronic kidney disease among patients with metabolic syndrome by Zhu, D, Judge, PK, Wanner, C, Haynes, R, Herrington, WG

“…In addition, statin-based regimens lower low-density lipoprotein cholesterol and reduce the risk of atherosclerotic disease (with no clinically meaningful effect on kidney outcomes). …”

Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML by Risueño, A, See, WL, Bluemmert, I, de Botton, S, DiNardo, CD, Fathi, AT, Schuh, AC, Montesinos, P, Vyas, P, Prebet, T, Gandhi, A, Hasan, M

“…We recently reported results from the phase 3 IDHENTIFY trial (NCT02577406) showing improved response rates and event-free survival with enasidenib monotherapy compared with conventional care regimens (CCR) in heavily pretreated, older patients with late-stage R/R AML bearing IDH2 mutations. …”

Varieties of indoctrination: the politicization of education and the media around the world by Neundorf, A, Nazrullaeva, E, Northmore-Ball, K, Tertytchnaya, KT, Kim, W

“…For many decades, scholars assumed voluntary compliance and citizens’ commitment to a regime’s principles and values to be critical for regime stability. …”

Dip coating of bidisperse particulate suspensions by Jeong, Deok-Hoon, Lee, Michael Ka Ho, Thiévenaz, Virgile, Bazant, Martin Z, Sauret, Alban

“…We also characterize the intermediate regime that consists of a heterogeneous coating layer and where the composition of the film is different from the composition of the bath. …”
Get full text

Enhancing quantum synchronization through homodyne measurement, noise, and squeezing by Shen, Yuan, Soh, Hong Yi, Fan, Weijun, Kwek, Leong Chuan

“…Homodyne measurement emerges as one of the successful candidates for this task but preferably in the semiclassical regime. In our work, we focus on the phase synchronization of a harmonic-driven quantum Stuart-Landau oscillator and show that the enhancement induced by homodyne measurement persists into the quantum regime. …”
Get full text

A review of offshore decommissioning regulations in five countries – strengths and weaknesses by Fam, Mei Ling, Konovessis, Dimitris, Tan, Hoon Kiang, Ong, Lin Seng

“…Major differences lie in two overarching philosophies of the framework - a prescriptive regime versus a goal-setting regime. Other decommissioning aspects appear to attract increasing attention, such as in expanding clarity on in situ decommissioning, residual liabilities, optimising finance related issues of decommissioning and offshore to onshore waste movement. …”
Get full text
Get full text

The effect of salt on oligocation-induced chromatin condensation by Korolev, Nikolay, Zhao, Yongqian, Allahverdi, Abdollah, Eom, Khee Dong, Nordenskiöld, Lars, Tam, James P.

“…In the salt-dependent regime EC50 rises sharply with increase of CKCl. Increase of ligand charge shifts the transition from the salt-independent to salt-dependent regime to higher salt. …”
Get full text
Get full text

Genomic profiling of mycobacterium tuberculosis strains, Myanmar by Aung, Htin Lin, Nyunt, Wint Wint, Fong, Yang, Biggs, Patrick J., Winkworth, Richard C., Lockhart, Peter J., Yeo, Tsin Wen, Hill, Philip C., Cook, Gregory M., Aung, Si Thu

“…Introducing new oral drugs to replace those currently used in treatment regimens for multidrug-resistant TB will also be useful for treating TB in Myanmar.…”
Get full text