Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

Managing oil palm plantations more sustainably : large-scale experiments within the Biodiversity and Ecosystem Function in Tropical Agriculture (BEFTA) Programme by Luke, Sarah H., Advento, Andreas Dwi, Aryawan, Anak Agung Ketut, Adhy, Dwi Nugroho, Ashton-Butt, Adham, Barclay, Holly, Dewi, Jassica Prajna, Drewer, Julia, Dumbrell, Alex J., Edi, Eycott, Amy E., Harianja, Martina F., Hinsch, Julie K., Hood, Amelia S. C., Kurniawan, Candra, Kurz, David J., Mann, Darren J., Matthews Nicholass, Kirsty J., Naim, Mohammad, Pashkevich, Michael D., Prescott, Graham W., Ps, Sudharto, Pujianto, Purnomo, Dedi, Purwoko, Rizky Rajabillah, Putra, Syafrisar, Rambe, T. Dzulfikar S., Soeprapto, Spear, Dakota M., Suhardi, Tan, David J. X., Tao, Hsiao-Hang, Tarigan, Ribka Sionita, Wahyuningsih, Resti, Waters, Helen S., Widodo, Rudi Harto, Whendy, Woodham, Christopher R., Caliman, Jean-Pierre, Slade, Eleanor M., Snaddon, Jake L., Foster, William A., Turner, Edgar C.

“…The Programme has established four major components: (1) assessing variability within the plantation under business-as-usual conditions; (2) the BEFTA Understory Vegetation Project, which tests the effects of varying herbicide regimes; (3) the Riparian Ecosystem Restoration in Tropical Agriculture (RERTA) Project, which tests strategies for restoring riparian habitat; and (4) support for additional collaborative projects within the Programme landscape. …”
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GPU-based commonsense reasoning for real-time query answering and multimodal analysis by Tran, Ha Nguyen

“…Secondly, in order to reason and retrieve information on rule-based knowledge bases, the thesis introduces gSparql, a fast and scalable inference and querying method on mass-storage RDF data with rule-based entailment regimes. Our approach accepts different rulesets and executes the reasoning process at query time when the inferred triples are determined by the set of triple patterns defined in the query. …”
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Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
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Light-matter interactions in atomically thin transition metal dichalcogenides by Zhao, Jiaxin

“…The system working in the strong coupling regime exhibits a clear anti-crossing behavior with a large Rabi splitting around 37 meV. …”
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STandards for reporting interventions in clinical trials of tuina/massage (STRICTOTM): extending the CONSORT statement by Zhang, Xuan, Liang, Feng, Lau, Chung Tai, Chan, Jacky C. P., Wang, Nana, Deng, Jiashuai, Wang, Juan, Ma, Yanfang, Zhong, Linda Lidan, Zhao, Chen, Yao, Liang, Wu, Taixiang, Lyu, Aiping, Tian, Guihua, Shang, Hongcai, Miao, Jiangxia, Bian, Zhaoxiang

“…Results: A checklist of seven items (namely Tuina/Massage rationale, details of Tuina/Massage, intervention regimen, other components of the intervention, Tuina/Massage provider background, control or comparator interventions, and precaution measures), and 16 subitems were developed. …”
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Towards electrically injected colloidal semiconductor lasers by Thung, Yi Tian

“…The NPL-VCSEL demonstrated a low lasing threshold of 21.6 W cm-2 with a single-mode Q-factor of 11800 under continuous-wave (cw) excitation, with good agreement between the cw-pumped lasing spectra and the ps pulse-pumped lasing spectra. to highlighting the NPL-VCSEL’s robustness under different optical pumping regimes, I demonstrated the NPL-VCSEL’s performance under continuous wave optical pump, affirming the suitability of the colloidal NPLs as the preferred gain medium to realize the desired electrically injected colloidal semiconductor lasers. …”
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Studies on plasma assisted molecular beam epitaxial growth of GaN-based multilayer heterostructures on Si for photodetector application by Zheng, Yi

“…Tunability of band gap and the possibility of formation of heterostructures with group III-nitride materials allow the design of complex structures to detect both UV and infra-red (IR) spectral regimes (multi band) on a single chip. By growing AlGaN/GaN multiple quantum well layers, IR detector can also be obtained, which means IR and UV detector can be achieved using the same material. …”
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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…The accuracy was further supported by the correlation between WTC-based test results and patients' clinical responses in a separate validation study, where the neoadjuvant treatment regimens of 15 BC patients were mimicked. Collectively, the WTC model allows us to accomplish personalized drug testing within 10 d, even for small-sized tumors, highlighting its potential for individualized BC therapy. …”
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Antiretroviral therapy optimisation without genotype resistance testing : a perspective on treatment history based models by Prosperi, Mattia C. F., Sloot, Peter M. A., van de Vijver, David A. M. C., Rosen-Zvi, Michal, Altmann, André, Zazzi, Maurizio, Schülter, Eugen, Struck, Daniel, Di Giambenedetto, Simona, Kaiser, Rolf, Vandamme, Anne-Mieke, Sönnerborg, Anders

“…Sensitivity analyses, carried out on a data subset that included antiretroviral regimens commonly used in low to middle income countries, confirmed our findings. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…Background: While the use of combination antiretroviral therapy (cART) has conferred significant reduction in morbidity and mortality, there are growing concerns about the metabolic complications of antiretroviral regimens in HIV-infected patients. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) among people living with HIV (PLHIV) in Singapore. …”
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Next generation design of floating systems for coastal solar farms by Bi, Cheng

“…In the single-barrier-platform system, the barrier is installed in front of the platform, and significant reduction in platform displacement can be achieved when the barrier is in the membrane-like hydroelastic regime with relatively high rigidity and has a penetration more than 40% of water depth. …”
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The dietetic practice of prescribing amino acid-based formulas in paediatrics patients without cow’s milk allergy: a single centre retrospective study by O’Connor, Graeme, Mansell, Melissa

“…Data were collected on demographics, anthropometrics, feed regimens, gastrointestinal symptoms, proton pump inhibitor use and serum phosphate concentration Results: 203 children were prescribed an AAF during the data collection period, of these, 154 of 203 (76%) patients had no allergies. …”
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EU competition law : a roadmap for ASEAN? by Valockova, Barbora

“…The European Union’s competition policy and legal regime is instrumental in the functioning of the single market in the EU. …”
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Dynamical blockade in a single-mode bosonic system by Ghosh, Sanjib, Liew, Timothy Chi Hin

“…We find that the underlying mechanism for the blockade is general, enhancing antibunching in the strongly nonlinear regime and inducing it in the weakly nonlinear regime, without fine-tuning the system parameters. …”
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Maxwell-type models for the effective thermal conductivity of a porous material with radiative transfer in the voids by Kiradjiev, KB, Halvorsen, SA, Van Gorder, RA, Howison, SD

“…In the high-temperature regime, radiative transfer within voids strongly influences the thermal conductivity of the bulk material. …”