A hydrophilic polyimidazolium antibiotic targeting the membranes of Gram-negative bacteria by Chen, Yahua, Yong, Melvin, Li, Ming, Si, Zhangyong, Koh, Chong Hui, Lau, Pearlyn, Chang, Yi Wei, Teo, Jeanette, Chan-Park, Mary B., Gan, Yunn-Hwen

“…The rise of MDR Gram-negative bacteria (GNB), especially those resistant to last-resort drugs such as carbapenems and colistin, is a global health risk and calls for increased efforts to discover new antimicrobial compounds. …”
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LipidA-IDER to explore the global lipid A repertoire of drug-resistant gram-negative bacteria by Guan, Xue Li, Loh, Johnathan Yi-Xiong, Lizwan, Marco, Chan, Sharon Cui Mun, Kwan, Jeric Mun Chung, Lim, Tze Peng, Koh, Tse Hsien, Hsu, Li Yang, Lee, Bernett Teck Kwong

“…With the global emergence of drug-resistant bacteria causing difficult-to-treat infections, there is an urgent need for a tool to facilitate studies on key virulence and antimicrobial resistant factors. …”
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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

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Lipopolysaccharide neutralizing peptide–porphyrin conjugates for effective photoinactivation and intracellular imaging of gram-negative bacteria strains by Liu, Fang, Soh, Annie Yan Ni, Lim, Yingjie, Mohanram, Harini, Bhattacharjya, Surajit, Xing, Bengang

“…In addition, the photodynamic bacterial inactivation also demonstrated more potent activity than the minimum inhibitory concentration (MIC) values of dimeric PpIX-YI13WF conjugate itself observed for E. coli DH5a (4 times), S. enterica (8 times), and other Gram-negative strains including antibiotic-resistant E. coli BL21 (8 times) and K. pneumoniae (16 times). …”
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Quorum sensing signal autoinducer-2 promotes hydrogen peroxide degradation in water by Gram-positive bacteria by Han, Shuo, Qin, Mengyuan, Wang, Yuqi, Gao, Chao, Niu, Wenfang, Han, Jingjing, Wang, Hailei, Li, Yi

“…Additionally, AI-2 can also encourage multiple Gram-positive bacteria to degrade hydrogen peroxide. …”
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Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents by Zhang, Kaixi, Raju, Cheerlavancha, Zhong, Wenbin, Pethe, Kevin, Gründling, Angelika, Chan-Park, Mary B.

“…By doing so, the co-β-peptide not only inhibits biofilm formation, it also disperses preformed biofilms in several Gram-positive bacteria and resensitizes methicillin-resistant Staphylococcus aureus to oxacillin. …”
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Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis by da Silva, Ronni A. G., Wong, Jun Jie, Antypas, Haris, Choo, Pei Yi, Goh, Karlyn, Jolly, Shreya, Liang, Cui, Tay, Leona Kwan Sing, Veleba, Mark, Hu, Guangan, Chen, Jianzhu, Kline, Kimberly A.

“…Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vitro and in vivo against vancomycin-resistant Enterococcus faecalis (VRE). We show that, in vitro, MTX is a potent antibiotic against Gram-positive bacteria through induction of reactive oxygen species and DNA damage. …”
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Prediction of pyrazinamide resistance in Mycobacterium tuberculosis using structure-based machine learning approaches by Carter, J, Walker, T, Walker, A, Whitfield, M, Morlock, G, Lynch, C, Adlard, D, Peto, T, Posey, J, Crook, D, Fowler, P

“…<p><strong>Methods</p></strong> We curated a dataset of 664 non-redundant, missense amino acid mutations in PncA with associated high-confidence phenotypes from published studies and then trained three different machine-learning models to predict pyrazinamide resistance. …”

Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Furthermore, those synthetic porphyrin-peptide conjugates indicated promising activities against Gram-negative pathogens even for those with antibiotics resistance upon the exposure to light irradiation. …”
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White-light-responsive prussian blue nanophotonic particles for effective eradication of bacteria and improved healing of infected cutaneous wounds by Chakraborty, Nayanika, Jha, Diksha, Singh, Vijay Pal, Kumar, Pradeep, Verma, Navin Kumar, Gautam, Hemant Kumar, Roy, Indrajit

“…With excellent photothermal and photodynamic properties, CHPB-FD nanoparticles can effectively eradicate both Gram-positive methicillin-resistant Staphylococcus aureus and Gram-negative Pseudomonas aeruginosa in vitro and in vivo. …”
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Proteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis by Chiang, Ming-Hsien, Chang, Fang-Ju, Kesavan, Dinesh Kumar, Vasudevan, Aparna, Xu, Huaxi, Lan, Kuo-Lun, Huang, Shu-Wei, Shang, Hung-Sheng, Chuang, Yi-Ping, Yang, Ya-Sung, Chen, Te-Li

“…Elizabethkingia anophelis, a nonfermenting Gram-negative bacterium, causes life-threatening health care-associated infections. …”
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Isolation, screening, identification, and characterization of arsenic resistant plant growth promoting rhizobacteria isolated from Pennisetum purpureum by Rahman, Md Ekhlasur, Shamsuzzaman, S.M., Mahmud, Khairil, Uddin, Md Kamal, Abd Ghani, Siti Salwa, Abd Shukor, Mohd Yunus, Chompa, Sayma Serine, Akter, Amaily, Nabayi, Abba, Sadeq, Buraq Musa, Halmi, Mohd Izuan Effendi

“…A total of 22 groups of bacterial isolates were confirmed based on the morphological characteristics, biochemical characteristics, and Gram staining. Preliminary and secondary As screening tests were also conducted. …”
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Identification of proteins and genes as potential biomarkers in brown-marbled grouper (Epinephelus fuscoguttatus forsskal) resistance to Vibrio sp by Low, Chen Fei

“…The gram-negative marine bacterium, Vibrio sp. has frequently been identified as the causative pathogen responsible for the infectious disease vibriosis in the marine aquaculture industry. …”
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Synergistic antibacterial action of lignin-squaraine hybrid photodynamic therapy: advancing towards effective treatment of antibiotic-resistant bacteria by Ferdinandus, Joo, Chaemin, Kai, Dan, Lee, Ken Chi-Lik

“…The hydrogel exhibited a significant aPDT effect on Gram-positive bacteria, hence showing its potential in combating antibiotic-resistant pathogenic bacteria in chronic wound infection.…”
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New multi-target based therapeutics against an opportunistic superbug by Premkumar, Jayaraman.

“…Pseudomonas aeruginosa (P. aeruginosa) is one of the most opportunistic and challenging Gram-negative pathogens, often resistant to a number of widely used antibiotics even when combination therapies are administered, thereby joining the ranks of “superbugs”. …”
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Designer broad-spectrum polyimidazolium antibiotics by Zhong, Wenbin, Shi, Zhenyu, Mahadevegowda, Surendra H., Liu, Bo, Zhang, Kaixi, Koh, Chong Hui, Ruan, Lin, Chen, Yahua, Zeden, Merve S., Pee, Carmen J. E., Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Zhu, Yabin, Chi, Robin Yonggui, Hammond, Paula T., Yang, Liang, Gan, Yunn-Hwen, Pethe, Kevin, Greenberg, E. Peter, Gründling, Angelika, Chan-Park, Mary B.

“…In similar experiments with the gram-negative pathogen Pseudomonas aeruginosa, PIM1-resistant mutants did not emerge. …”
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Cationic polymer-based antimicrobial and multifunctional hydrogels for enhanced healing of infected wounds by Po, Javier Jun Fai

“…Whereas, PIM-Dextran MA (PIM-Dex) hydrogels was observed to only kill Gram-positive MRSA bacteria but not Gram-negative PAER bacteria. …”
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Rational design and synthesis of degradable poly(imidazolium ester) antibiotics by Xu, Xiaofei

“…Notably, it effectively eliminated both Gram-positive and Gram-negative multidrug-resistant strains in murine infections. …”
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Antibiotic sensitivity of selected bacteria and microbiological quality of Lactobacillus-fed broiler meat in comparison with commercial broiler meat by Tan, Stephanie Yin Yi

“…For Salmonella sp., all isolates from both types of meat were found to be resistant to ceftriaxone and oxytetracycline. E. coli from both types of chicken were resistant to ceftriaxone, ampicillin, streptomycin and oxytetracycline, while resistance towards ciprofloxacin was observed in one isolate from commercial broiler meat. …”
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Outer-membrane permeabilization, LPS transport inhibition: activity, interactions, and structures of thanatin derived antimicrobial peptides by Swaleeha Jaan Abdullah, Yan, Bernice Tan Siu, Palanivelu, Nithya, Dhanabal, Vidhya Bharathi, Bifani, Juan Pablo, Bhattacharjya, Surajit

“…Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-negative bacteria are highly limited. …”
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