Swimming upregulates APOL3 through regulating macrophage polarization to inhibit glycolysis and the development of melanoma by Lyu, Zhenlei, Mahenderan, Appukutty, Radhakrishnan, Ammu Kutty G. K., Chin, Yit Siew, Yin, Chao

“…This study investigated the role of swimming exercise in regulating melanoma tumour growth and glycolysis in cancer cells, the specific mechanism involved was also studied. …”
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Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark by Alonso-Serra, Juan, Safronov, Omid, Lim, Kean-Jin, Fraser-Miller, Sara J., Blokhina, Olga B., Campilho, Ana, Chong, Sun-Li, Fagerstedt, Kurt, Haavikko, Raisa, Helariutta, Ykä, Immanen, Juha, Kangasjärvi, Jaakko, Kauppila, Tiina J., Lehtonen, Mari, Ragni, Laura, Rajaraman, Sitaram, Räsänen, Riikka-Marjaana, Safdari, Pezhman, Tenkanen, Maija, Yli-Kauhaluoma, Jari T., Teeri, Teemu H., Strachan, Clare J., Nieminen, Kaisa, Salojärvi, Jarkko

“…A detailed analysis of suberin and betulin biosynthesis pathways identified a set of underlying regulators and highlighted the important role of local, small-scale gene duplication events in the evolution of metabolic pathways. …”
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Super-enhancers, phase-separated condensates, and 3D genome organization in cancer by Tang, Seng Chuan, Vijayakumar, Udhaya, Zhang, Ying, Fullwood, Melissa Jane

“…3D chromatin organization plays an important role in transcription regulation and gene expression. …”
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Persistent spectral simplicial complex-based machine learning for chromosomal structural analysis in cellular differentiation by Gong, Weikang, Wee, Junjie, Wu, Min-Chun, Sun, Xiaohan, Li, Chunhua, Xia, Kelin

“…The three-dimensional (3D) chromosomal structure plays an essential role in all DNA-templated processes, including gene transcription, DNA replication and other cellular processes. …”
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Nitrifying niche differentiation in biofilms from full-scale chloraminated drinking water distribution system by Cruz, Mercedes Cecilia, Woo, Yissue, Flemming, Hans-Curt, Wuertz, Stefan

“…Moreover, there is a general lack of understanding of the role of microbial communities in DWDS in regions with warm temperatures and no distinct seasons. …”
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Studies on the Chitin Binding Property of Novel Cysteine-Rich Peptides from Alternanthera sessilis by Kini, Shruthi G., Nguyen, Phuong Q. T., Weissbach, Sophie, Mallagaray, Alvaro, Shin, Joon, Yoon, Ho Sup, Tam, James P.

“…Hevein-like peptides make up a family of cysteine-rich peptides (CRPs) and play a role in plants in their defense against insects and fungal pathogens. …”
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Reassessing the association: evaluation of a polyalanine deletion variant of RUNX2 in non-syndromic sagittal and metopic craniosynostosis by Walton, IS, McCann, E, Weber, A, Morton, JEV, Noons, P, Wilson, LC, Ching, RC, Cilliers, D, Johnson, D, Phipps, JM, Shears, DJ, Thomas, GPL, Wall, SA, Twigg, SRF, Wilkie, AOM

“…The RUNT-related transcription factor RUNX2 plays a critical role in osteoblast differentiation, and alterations to gene dosage cause distinct craniofacial anomalies. …”

Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…In Arabidopsis, intronic and exonic SREs played comparable roles, suggesting a greater role for intronic information in plants compared with animals. …”
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Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…Based on this finding, we proposed that the role of ZαADAR1 in binding to ribosomes and inhibiting translation is to recognize potentially Z-forming structures and/or induce localized structural transitions from A- to Z-conformations in ribosomal RNA. …”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. …”
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Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

“…The nucleotide sequence of the MrNv capsid gene isolated from a Malaysian isolate was sequenced and later compared with those available in the NCBI database. …”
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A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…Mounting evidence indicates that CSCs play a critical role in cancer growth, metastasis, relapse, and resistance to radiotherapy and chemotherapy. …”
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The metal ion-dependent adhesion site motif of the Enterococcus faecalis EbpA pilin mediates pilus function in catheter-associated urinary tract infection by Nielsen, Hailyn V., Guiton, Pascale S., Kline, Kimberly A., Port, Gary C., Pinkner, Jerome S., Neiers, Fabrice, Normark, Staffan, Henriques-Normark, Birgitta, Caparon, Michael G., Hultgren, Scott J.

“…However, the endocarditis- and biofilm-associated pilus (Ebp), a member of the sortase-assembled pilus family, was shown to play a role in a mouse model of E. faecalis ascending UTI. …”
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Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis by Singal, Bharti

“…Mtb shows a single functional copy of the relA gene which encodes the bifunctional protein MtRel, responsible to synthesize and hydrolyse the effector molecules. …”
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Characterization of exopolysaccharides from probiotic Lactobacillus strains isolated from traditional Malaysian foods by Suliman, Eilaf Suliman Khalil

“…Lactic acid bacteria (LAB) are generally recognized as safe (GRAS) microorganisms, and play an important role in food and animal feed as potential probiotics. …”
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Fine-scale population structure and widespread conservation of genetic effect sizes between human groups across traits by Hu, S, Ferreira, LAF, Shi, S, Hellenthal, G, Marchini, J, Lawson, DJ, Myers, SR

“…ANCHOR infers highly similar (estimated correlation 0.98 ± 0.07) effect sizes between UK Biobank participants of African and European ancestry for 47 of 53 quantitative phenotypes, suggesting that gene–environment and gene–gene interactions do not play major roles in poor cross-ancestry PGS transferability for these traits in the United Kingdom, and providing optimism that shared causal mutations operate similarly in different populations.…”

Molecular studies of coronavirus replication and pathogenesis by Li, Qisheng

“…Host factors participate in most steps of virus life cycle. Concomitantly, host gene expression and defenses are modulated by viruses to optimize viral replicatio. …”
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Understanding early molecular mechanisms of abnormal myelination in neurological conditions by characterising Ermin deficiency by Oh, Sher Li, Ziaei, Amin, Tan, Liang Juin, Utami, Kagistia Hana, Pouladi, Mahmoud A., Langley, Sarah Raye

“…We observed altered expression of transcription factors at early ages, and in protein processing and synaptic function over time. In silico gene perturbation and ChIP-seq analysis were used to elucidate the roles that differentially expressed transcription factors play in oligodendrocyte differentiation and as well as in their effects on protein processing and synaptic function. …”
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Assessment of gut microbiome variations in the mother and twin infant of captive white-handed gibbons (Hylobates lar) reveals the presence of beneficial and nonpathogenic bacteria by Badrul Munir Md-Zain, Siti Hajar Azmi, Roberta Chaya Tawie Tingga, Millawati Gani, Mohamad Khairulmunir, Abd Rahman Mohd-Ridwan

“…The gut microbiota of H. lar was dominated by phylum Firmicutes and Bacteroidota because of their important roles in fermentation and nutrient assimilation from plant-based food sources. …”
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A pilot study on peptidylarginine deiminases and protein deimination in animal cancers across vertebrate species by Inal, Jameel, Hristova, Mariya, Lange, Sigrun

“…PADs are a group of calcium-dependent enzymes that play key roles in inflammatory pathologies and have diverse roles in cancers. …”
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