The role of the 235 kDA protein multigene family (py235) of the malaria parasite Plasmodium yoelii in invasion and host cell selection, virulence and immune evasion by Jayasree Kaveri Iyer

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Revealing the potential role of hsa-miR-663a in modulating the PI3K-Akt signaling pathway via miRNA microarray in spinal muscular atrophy patient fibroblast-derived iPSCs by Gandhi, Gayatri, Kodiappan, Radha, Abdullah, Syahril, Teoh, Hoon Koon, Tai, Lihui, Cheong, Soon Keng, Yeo, Wendy Wai Yeng

“…Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder due to deletion or mutation of survival motor neuron 1 (SMN1) gene. Although survival motor neuron 2 (SMN2) gene is still present in SMA patients, the production of full-length survival motor neuron (SMN) protein is insufficient owing to missing or mutated SMN1. …”
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Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB by Fazli, Mustafa, Rybtke, Morten, Steiner, Elisabeth, Weidel, Elisabeth, Berthelsen, Jens, Groizeleau, Julie, Bin, Wu, Zhi, Boo Zhao, Yaming, Zhang, Kaever, Volkhard, Givskov, Michael, Hartmann, Rolf W., Eberl, Leo, Tolker-Nielsen, Tim

“…We provide evidence that c‐di‐GMP, the alternative sigma factor RpoN (σ54), and the enhancer‐binding protein BerB play a role in biofilm formation of Burkholderia cenocepacia by regulating the production of a biofilm‐stabilizing exopolysaccharide. …”
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Manufacturing mesenchymal stromal cells in a microcarrier-microbioreactor platform can enhance cell yield and quality attributes: case study for acute respiratory distress syndrome by Krupczak, Brandon, Farruggio, Camille, Van Vliet, Krystyn J.

“…Next, we identified 24 genes implicated in a therapeutic role for a specific motivating indication, acute respiratory distress syndrome (ARDS); expression of these genes served as our pCQAs for initial in vitro evaluation of product potency. …”
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Regulation and function of innate-like T cells by Hagel, JP

“…The ability of CD161-expressing T cells to also express IL-32 upon activation was demonstrated in vitro. To elucidate the role of IL-32 in disease, a pan-cancer IL32 gene signature was generated from The Cancer Genome Atlas (TCGA) RNA-seq data. …”

Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer by Wongsurawat, Thidathip

“…Integrative genomics analyses suggested that RLFSs could play a role in gene regulation, AID/APOBEC-mediated editing/mutagenesis, alternative splicing, and epigenetic modifications, and also associate with mutations in cancer, neurodegenerative diseases and mental disorders. …”
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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. …”
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Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…Differentially expressed genes were reported and individual genes were grouped into gene families and enriched pathways to provide functional relevance. …”

Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Understanding the underlying concepts of human genetics, especially the role of genes, is important for applying genetic and genomic information as well as technologies in healthcare. …”
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Temperature induced biological alterations in the major carp, Rohu (Labeo rohita): assessing potential effects of climate change on aquaculture production by Mridul, Md. Monirul Islam, Zeehad, Md. Shariar Kabir, Aziz, Dania, Salin, Krishna R., Hurwood, David A., Rahi, Md. Lifat

“…Temperature plays a profound role in organismal growth, immunity, survival, and the entire biological systems of any aquatic species. …”
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Effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in glioblastoma multiforme cancer stem cells under hypoxia and normoxia conditions by Vazifehmand, Reza, Saeed Ali, Dhuha, Monem Homaie, Foroozandeh, Molaei Jalalvand, Fatemeh, Othman, Zulkefley, Deming, Chau, Stanslas, Johnson, Sekawi, Zamberi

“…Furthermore, hTERC, DKC1, and TEP1 genes were significantly dysregulated in hypoxic and normoxic mi-croenvironments. …”

Molecular cloning, expression, purification and crystallization of BcsG for structural analysis in escherichia coli by Lee, Jin

“…Genes such as BcsG have been found to play a crucial role in cellulose synthase formation as well and yet, little is known about BcsG apart from functional studies and theorized interaction with other Bcs proteins. …”
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Effect of vitamin A on adult lung function: a triangulation of evidence approach by Mongey, R, van der Plaat, DA, Shaheen, SO, Portas, L, Potts, J, Hind, MD, Minelli, C

“…Background: Vitamin A, an essential micronutrient obtained through the diet, plays a crucial role in lung development and contributes to lung regeneration. …”

Functional metagenomic analysis of quorum sensing signaling in a nitrifying community by Tan, Chuan Hao, Yeo, Yee Phan, Muhammad Hafiz Ismail, Ng, Noele Kai Jing, Subramoni, Sujatha, Taj, Shireen, Tay, Martin, Chao, Xie, Kjelleberg, Staffan, Rice, Scott A.

“…In wastewater treatment systems, acylated homoserine lactone (AHL)-based QS has been correlated with the conversion of floccular biomass into microbial granules, as well as EPS production and the nitrogen removal process. However, the role of QS in such complex communities is still not fully understood, including the QS-proficient taxa and the functional QS genes involved. …”
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Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…Transcripts differentially expressed included biosynthetic and metabolic genes, flagellar and chemotaxis genes, genes encoding cell wall and outer membrane proteins, and transcriptional and translational regulators. …”
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Analysis and characterization of nervous system defects in candidate mutations resulting from a mutagenesis screen in the fruit fly, Drosophila melanogaster by Joanita Jasmen

“…In addition, attempts to disrupt the function of RNAse III enzymes gave no hint of the role of endogenous RNA interference (RNAi) in DA neuron differentiation and maintenance. …”
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Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…</p> <p>The screens were able to identify functionally relevant hits such as PTEN and INSR, which are known regulators of hepatic insulin signalling, as well as genes with a previously uncharacterised role in this pathway. …”

Colonic mucosal microbiota and association of bacterial taxa with the expression of host antimicrobial peptides in pediatric ulcerative colitis by Jalanka, Jonna, Cheng, Jing, Hiippala, Kaisa, Ritari, Jarmo, Salojärvi, Jarkko, Ruuska, Tarja, Kalliomäki, Marko, Satokari, Reetta

“…Over 200 genetic risk loci are associated with IBD, highlighting a key role for immunological and epithelial barrier functions. …”
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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…Such mixed genotypes complicate analysis of the role of the targeted gene in the studied cell population. …”
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The involvement of hypoxia in APOBEC-mediated mutagenesis in multiple cancers by Liang, J

“…APOBEC proteins are normally involved in innate immunity, playing a role in the defence against foreign genetic material by inducing mutations in single-stranded DNA and RNA. …”