The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis by Ng, Shi-Yan, Bogu, Gireesh K., Soh, Boon Seng, Stanton, Lawrence Walter

“…Here, we provide mechanistic insight into the role of human RMST in modulating neurogenesis. RMST expression is specific to the brain, regulated by the transcriptional repressor REST, and increases during neuronal differentiation, indicating a role in neurogenesis. …”
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GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…Although previous characterization of golden2 (g2) mutants in maize has demonstrated a role for GLK2 paralogs in regulating chloroplast biogenesis in bundle sheath cells, the function of GLK1 has remained elusive. …”

Uncovering the function of CREB regulated transcription coactivator 2 (CRTC2) in rodent brain by Lim, Wei Lee

“…In the brain, CRTC2 is expressed in the hypothalamus and hippocampus. To date, the role for CRTC2 in the hippocampus has not been described. …”
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Investigating factors contributing to enhancer-promoter interaction by Cornell, LJ

“…Enhancer-promoter interactions are drivers of tissue-specific gene expression and there are several mechanisms which contribute to their establishment and maintenance. …”

Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

“…In paper I, we present a present a novel way of using CRISPR-mediated gene knock out to validate the role of target genes in particular cellular pathways of interest. …”
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Expanding the CRISPR Toolbox for Engineering Lycopene Biosynthesis in Corynebacterium glutamicum by Zhan, Zhimin, Chen, Xiong, Ye, Zhifang, Zhao, Ming, Li, Cheng, Gao, Shipeng, Sinskey, Anthony J., Yao, Lan, Dai, Jun, Jiang, Yiming, Zheng, Xueyun

“…Particularly, cg0722, a membrane protein gene, was found to play a vital role in lycopene production. …”
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PRMT5 controls the innate immune response by Zhang, C

“…</p> <p>Transfection of HCT116 cells with intron-retained genes resulted in elevated dsRNA and IFN-β levels. …”

REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells by Huang, Tan, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…The transcription repressor, Repressor Element-1 Silencing Transcription factor (REST), which acts as an epigenetic regulator, is a crucial regulator of neuronal and glial gene expression. In this study, we identified and investigated the role of REST-target genes in human brain tissues, cerebral organoids, and neural cells in Down syndrome. …”
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Epigenetic analysis of hepatocellular carcinoma development : involvement of HBV-modulated DNA methylation by Niu, Dandan

“…To investigate comprehensively the role of HBV/HBx in DNA methylation, a protein profile affected by HBV in HBV-producing HepG2.2.15 cells compared with HepG2, was analyzed by our iTRAQ-coupled 2-D LC/MS-MS analysis. …”
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Characterization of the translational regulation of BIM 3’ UTR by Ho, Jessie Jia Xin

“…Genomic variations of the BIM gene were shown to account for drug resistance. MicroRNAs (miRNA) play a role in post-transcriptional regulation by binding to the messenger RNA (mRNA) 3’ untranslated region (UTR) of protein coding genes which include BIM. …”
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The core- and pan-genomic analyses of the genus Comamonas : from environmental adaptation to potential virulence by Wu, Yichao, Zaiden, Norazean, Cao, Bin

“…In this study, we provide genomic insights into the potential ecological roles and virulence of Comamonas by analysing the entire gene set (pangenome) and the genes present in all genomes (core genome) using 34 genomes of 11 different Comamonas species. …”
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Two clustering problems in analyzing next generation sequencing data by Ye, Tian

“…DNA methylation is a significant epigenetic modification to regulate gene transcription and plays a critical role in diseases. …”
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The bHLH transcription factor OsPRI1 activates the Setaria viridis PEPC1 promoter in rice by Carvalho, P, Gomes, C, Gonçalves, I, Lourenço, TF, Vlad, D, Langdale, JA, Saibo, NJM

“…This promoter drives mesophyll-specific gene expression in rice. The role of OsPRI1 <i>in planta</i> was characterized using a rice line harbouring <i>SvPEPC1_pro::GUS</i>.…”

Effects of nnav1.5 expression modulation on mhc I antigen processing machinery and invasion potential of breast cancer cells by Din, Ahmad Hafiz Murtadha Noor

“…Gene expression of nNav1.5 and two metastatic markers, MMP1 and FN1, were included. …”
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Characterization of artemisinin resistance in plasmodium falciparum by Rocamora, Frances Maureen C.

“…Genomic characterization of both parasite lines also identified a spectrum of mutated and copy number-variable genes that could play a role in mediating artemisinin sensitivity. …”
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Effect of detergent, herbs and spices on the growth of Vibrio parahaemolyticus biofilm in seafood by Nillian, Elexson

“…The prevalence of 9.14% (36/394) of positive toxR genes, 63.8% of positive isolates contained virulent genes of V. parahaemolyticus tdh+, 22.2% of V. parahaemolyticus trh+, and 5.56% (2/36) of positive isolates in both V. parahaemolyticus tdh+ and trh+ had been detected. …”
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Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…After the production of labels, I present the figures using a novel visualisation tool which allows a user to explore the images alongside with the labels describing localisation for each gene and the different compartments examined for each gene. …”

Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

“…</p> <p>Examination of TFE3 activation in iPSC-DaNs demonstrated a major role for upregulating lysosomal biogenesis and function, more so than TFEB activation. …”

Reverse translational approaches to population neuroimaging: using rodent models to interpret genetic associations with MRI by Tisca, C

“…<p>Mouse models play an essential role in advancing research in humans. The genetic similarity between humans and mice means we can measure and compare equivalent phenotypes across species. …”

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT by Seddon, C, David, S, Wong, JLC, Ishimoto, N, He, S, Bradshaw, J, Low, WW, Frankel, G, Beis, K

“…Conjugation plays a major role in dissemination of antimicrobial resistance genes. …”