Investigating the human teashirt genes TSHZ2 and TSHZ3 in pancreatic and endocrine lineage commitment using genome modified human embryonic stem cells (hESC) by Eng, Shermaine Zi Hui

“…To better understand the role of these genes in human pancreatic development, the expression of TSHZ2 Variant 1 and TSHZ3 was characterized, revealing a novel spliced variant of TSHZ2 Variant 1. …”
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Human Wharton's jelly mesenchymal stem cells show unique gene expression compared with bone marrow mesenchymal stem cells using single-cell RNA-sequencing by Barrett, Angela N., Fong, Chui-Yee, Subramanian, Arjunan, Liu, Wenting, Feng, Yirui, Choolani, Mahesh, Biswas, Arijit, Rajapakse, Jagath Chandana, Bongso, Ariff

“…We identified 436 significantly differentially expressed genes between the two cell types, playing roles in processes, including immunomodulation, angiogenesis, wound healing, apoptosis, antitumor activity, and chemotaxis. …”
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The Oryza sativa stress associated protein (OsSAP) promoter modulates gene expression in response to abiotic stress by utilizing cis regulatory elements within the promoter region by Nur Aminah Mohd Hazbir, Khairun Nisha Japlus, Amirah Mohammad-Sidik, Su Datt Lam, Nurulhikma Md Isa

“…Previous studies have identified the Oryza sativa Stress Associated Protein (OsSAP) genes to play a significant role in responding to abiotic stress. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…The second project of the part is the rational design of novel clickable membrane vesicles (MVs) for tumor-targeted drug/gene delivery. The cell derived MVs are of important self-assembled membrane structures, which are found to play critical roles in antigen presentation, cell to cell communication, cell migration and so on.14-16 In our research, a novel chemical engineered membrane vesicle was developed by introducing an amphiphilic benzophenone derivative into membranes. …”
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Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB by Fazli, Mustafa, Rybtke, Morten, Steiner, Elisabeth, Weidel, Elisabeth, Berthelsen, Jens, Groizeleau, Julie, Bin, Wu, Zhi, Boo Zhao, Yaming, Zhang, Kaever, Volkhard, Givskov, Michael, Hartmann, Rolf W., Eberl, Leo, Tolker-Nielsen, Tim

“…We provide evidence that c‐di‐GMP, the alternative sigma factor RpoN (σ54), and the enhancer‐binding protein BerB play a role in biofilm formation of Burkholderia cenocepacia by regulating the production of a biofilm‐stabilizing exopolysaccharide. …”
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The core- and pan-genomic analyses of the genus Comamonas : from environmental adaptation to potential virulence by Wu, Yichao, Zaiden, Norazean, Cao, Bin

“…In this study, we provide genomic insights into the potential ecological roles and virulence of Comamonas by analysing the entire gene set (pangenome) and the genes present in all genomes (core genome) using 34 genomes of 11 different Comamonas species. …”
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Regulation and function of innate-like T cells by Hagel, JP

“…The ability of CD161-expressing T cells to also express IL-32 upon activation was demonstrated in vitro. To elucidate the role of IL-32 in disease, a pan-cancer IL32 gene signature was generated from The Cancer Genome Atlas (TCGA) RNA-seq data. …”

TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to mediate seed oil biosynthesis by Kong, Que, Singh, Sanjay K., Mantyla, Jenny J., Pattanaik, Sitakanta, Guo, Liang, Yuan, Ling, Benning, Christoph, Ma, Wei

“…Cross-family transcription factor (TF) interactions play critical roles in the regulation of plant developmental and metabolic pathways. …”
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Transcriptomics of manually isolated Amborella trichopoda egg apparatus cells by Flores-Tornero, María, Proost, Sebastian, Mutwil, Marek, Scutt, Charles P., Dresselhaus, Thomas, Sprunck, Stefanie

“…Gene products include secreted proteins, such as small cysteine-rich proteins previously reported to act as extracellular signaling molecules with important roles during double fertilization. …”
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Elucidating the effects of DNA modification on transcription by Yavorska, O

“…<p>DNA modifications play important roles in genome function of vertebrates. 5-methylcytosine (mC) has been extensively studied over the last 50 years as the most common covalent DNA modification, present at roughly 70% of CpGs in the human genome. …”

Using machine learning to discover candidate localised transcripts from microscopy and genome-wide bioinformatics data by Kiourlappou, M

“…After the production of labels, I present the figures using a novel visualisation tool which allows a user to explore the images alongside with the labels describing localisation for each gene and the different compartments examined for each gene. …”

Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer by Wongsurawat, Thidathip

“…Integrative genomics analyses suggested that RLFSs could play a role in gene regulation, AID/APOBEC-mediated editing/mutagenesis, alternative splicing, and epigenetic modifications, and also associate with mutations in cancer, neurodegenerative diseases and mental disorders. …”
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Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…This chapter focussed specifically on the role of the sympathetic nervous system as a primary causative factor in the aetiology of hypertension, and presented evidence highlighting a critical role for impaired cyclic nucleotide signalling in sympathetic over-activity.…”

Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. …”
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Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Understanding the underlying concepts of human genetics, especially the role of genes, is important for applying genetic and genomic information as well as technologies in healthcare. …”
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Identification and functional analysis of Git3 G protein-coupled receptors in Ganoderma boninense PER71 by Khairunnisa Hanisah Mohd Daud, Mohd Faizal Abu Bakar, Izwan Bharudin, Shazilah Kamaruddin, Huai, Doris Xia Quay, Farah Diba Abu Bakar, Abdul Munir Abdul Murad

“…G protein-coupled receptors (GPCRs) are integral components of eukaryotic heterotrimeric G proteins, playing crucial roles in detecting extracellular signals and initiating the activity of signaling proteins within cells to activate cellular responses to these signals. …”
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Chromosome-level genome assembly of the diploid blueberry Vaccinium darrowii provides insights into its subtropical adaptation and cuticle synthesis by Cui, Fuqiang, Ye, Xiaoxue, Li, Xiaoxiao, Yang, Yifan, Hu, Zhubing, Overmyer, Kirk, Brosché, Mikael, Yu, Hong, Salojärvi, Jarkko

“…This conserved genome structure may explain the high fertility observed during crossbreeding of V. darrowii with other blueberry cultivars. Analysis of gene expansion and tandem duplication indicated possible roles for defense- and flowering-associated genes in the adaptation of V. darrowii to the subtropics. …”
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Temperature induced biological alterations in the major carp, Rohu (Labeo rohita): assessing potential effects of climate change on aquaculture production by Mridul, Md. Monirul Islam, Zeehad, Md. Shariar Kabir, Aziz, Dania, Salin, Krishna R., Hurwood, David A., Rahi, Md. Lifat

“…Temperature plays a profound role in organismal growth, immunity, survival, and the entire biological systems of any aquatic species. …”
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Molecular cloning, expression, purification and crystallization of BcsG for structural analysis in escherichia coli by Lee, Jin

“…Genes such as BcsG have been found to play a crucial role in cellulose synthase formation as well and yet, little is known about BcsG apart from functional studies and theorized interaction with other Bcs proteins. …”
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Effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in glioblastoma multiforme cancer stem cells under hypoxia and normoxia conditions by Vazifehmand, Reza, Saeed Ali, Dhuha, Monem Homaie, Foroozandeh, Molaei Jalalvand, Fatemeh, Othman, Zulkefley, Deming, Chau, Stanslas, Johnson, Sekawi, Zamberi

“…Telomerase activity and telomere length alterations have been known to play a critical role in glioblastoma progression and invasion. Objective: This study aimed to investigate the effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in U251GBMCSCs (U251-Glioblastoma cancer stem cells) under hypoxia and normoxia conditions. …”