United Nations and regional organizations : bridging the gap in the 21st century. by Francis Heartman Amuzu.

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Targeting TFEB and TFE3 in iPSC-derived dopaminergic neurons to correct autophagic/lysosomal deficits in Parkinson's disease by McGuinness, W

“…Mutations in PD-related genes such as <em>GBA</em>, <em>LRRK2</em> and <em>SNCA</em> have all been implicated to present deficits in lysosomal catabolic pathways.…”

CAN communication of power converters system for aerospace application by Imam Agung Raharja

“…The project is Industrial Sponsored Project (ISP) with Rolls-Royce Singapore Pte Ltd. The project aims to design the CAN communication system for the aerospace power system from the scratch. …”
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The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis by Ng, Shi-Yan, Bogu, Gireesh K., Soh, Boon Seng, Stanton, Lawrence Walter

“…Here, we provide mechanistic insight into the role of human RMST in modulating neurogenesis. RMST expression is specific to the brain, regulated by the transcriptional repressor REST, and increases during neuronal differentiation, indicating a role in neurogenesis. …”
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Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT by Seddon, C, David, S, Wong, JLC, Ishimoto, N, He, S, Bradshaw, J, Low, WW, Frankel, G, Beis, K

“…Conjugation plays a major role in dissemination of antimicrobial resistance genes. …”

Epigenetic analysis of hepatocellular carcinoma development : involvement of HBV-modulated DNA methylation by Niu, Dandan

“…DNA methylation, one of the mechanisms in epigenetics, affects gene expression at the transcriptional level. Evidence has revealed the association between HCC and HBV-mediated DNA methylation. …”
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Characterization of the translational regulation of BIM 3’ UTR by Ho, Jessie Jia Xin

“…Genomic variations of the BIM gene were shown to account for drug resistance. MicroRNAs (miRNA) play a role in post-transcriptional regulation by binding to the messenger RNA (mRNA) 3’ untranslated region (UTR) of protein coding genes which include BIM. …”
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Antimicrobial susceptibility and molecular profiles of acinetobacter baumannii in Makkah hospitals, and the potential use of bacteriophage as a treatment option by Raees, Fahad

“…This study also found 75.7% and 73.0% of the tested MDR A. baumannii isolated from Makkah hospitals acquired mph(E) and msr(E) macrolides resistant genes respectively. The aminoglycosides resistance was encoded mainly by aminoglycoside phosphor-transferase gene, aph(3′′)-Ib at 83.8% and aminoglycoside O-phosphotransferase aph(6)-Id at 70.3%. …”
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GOLDEN2-like1 is sufficient but not necessary for chloroplast biogenesis in mesophyll cells of C4 grasses by Lambret-Frotte, J, Smith, G, Langdale, J

“…Although previous characterization of golden2 (g2) mutants in maize has demonstrated a role for GLK2 paralogs in regulating chloroplast biogenesis in bundle sheath cells, the function of GLK1 has remained elusive. …”

Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis by Huang, Tan, Lam, Xin-Jieh, Lim, Chong-Teik, Jusoh, Norhazlin, Fakurazi, Sharida, Cheah, Pike-See, Ling, King-Hwa

“…Notably, Alzheimer ’s-related genes and proteins play a pervasive role in DS neuropathological processes across patients' lifespans. …”
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Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells. by Tan, Bee Kim.

“…Recently, lentiviral vectors represented a tool to achieve a transient mode of gene-delivery to silence genes in hematopoetic cells. …”
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Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…This study focuses on Nurr1, an orphan nuclear receptor, due to its essential role in the survival and maintenance of dopaminergic neurons in the substantia nigra of the brain. …”
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Identification of microRNA targets for the alternative splicing isoforms of CD46. by Teo, Zhi Lin.

“…Some tumor cells are found to overexpress CD46, suggesting its probable role in cancer. Given the multitude roles of CD46, its regulation should have important implications in many biological processes. …”
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Actinorhodopsin: an efficient and robust light-driven proton pump for bionanotechnological applications by Ayoub, N, Djabeur, N, Harder, D, Jeckelmann, J, Ucurum, Z, Hirschi, S, Fotiadis, D

“…Actinorhodopsins are encoded by a distinct group of microbial rhodopsin (MR) genes predominant in non-marine actinobacteria. Despite their role in the global energy cycle and potential for bionanotechnological applications, our understanding of actinorhodopsin proteins is limited. …”

Knowledge and Learning in Organizations : A Knowing-In-Practice Perspective of University Academic Managers / by Larentis, Fabiano author 655495, Antonello, Claudia Simone author 655496, SpringerLink (Online service) 666

“…Hence, academic-managers are supposed to deal with a multiplicity of activities and interpersonal relationships. …”
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Assessment of gut microbiome variations in the mother and twin infant of captive white-handed gibbons (Hylobates lar) reveals the presence of beneficial and nonpathogenic bacteria by Badrul Munir Md-Zain, Siti Hajar Azmi, Roberta Chaya Tawie Tingga, Millawati Gani, Mohamad Khairulmunir, Abd Rahman Mohd-Ridwan

“…Next-generation sequencing (NGS) of the 16S rRNA gene was performed. The NGS data were analyzed on the basis of amplicon sequence variation. …”
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Colloidal fouling and scaling in reverse osmosis process by Jun, Yan

“…Despite having majority of the earth surface covered by water, accessing safe water source is an increasing challenge faced by human population. Hence, recycling used water and converting non-potable water to potable are the options being adopted in alleviating the issue. …”
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Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis by Noble, A, Motta, R, Cabras, S, Flores, BM, Nowak, J, Glapa-Nowak, A, Geremia, A, Satsangi, J, Culver, E

“…IgG4-SC and PSC shared 8 probes. Inflammatory genes (including CEP97, IFNAR1, TXK, HERC6, C5orf36, PYY, and MTRNR2L1) were predominantly involved in dysregulated methylation. …”

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Raj Murthi, S, Petry, A, Shashikadze, B, Stöckl, JB, Schmid, M, Santamaria, G, Klingel, K, Kračun, D, Chen, X, Bauer, S, Schmitt, JP, Flenkenthaler, F, Gorham, J, Toepfer, CN, Potěšil, D, Hruška, P, Zdráhal, Z, Mayer, Z, Klop, M, Lehmann, L, Qin, Y, Papanakli, L, Spielmann, N, Moretti, A

“…Hypertrophic cardiomyopathy (HCM) caused by autosomal-dominant mutations in genes coding for structural sarcomeric proteins, is the most common inherited heart disease. …”

Design and analysis of a flexure bearing by Balakrishnan Sathish Kumar

“…Flexure bearings play a major role in the field of ultra-precision mechanical design. …”
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