The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…<p>The central role of calcium ions in the generation of contractile force in the heart has been understood for many decades. …”

The habenula clock influences response to a stressor by Basnakova, Adriana, Cheng, Ruey-Kuang, Chia, Joanne Shu Ming, D'Agostino, Giuseppe, Suryadi, Tan, Germaine Jia Hui, Langley, Sarah Raye, Jesuthasan, Suresh

“…Two-photon calcium imaging indicates a circadian change in spontaneous activity of habenula neurons. To assess the role of this clock, a truncated clocka gene was specifically expressed in the habenula. …”
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Sonodynamic Nano-LYTACs reverse tumor immunosuppressive microenvironment for cancer immunotherapy by Xu, Mengke, Hu, Yuxuan, Wu, Jiayan, Liu, Jing, Pu, Kanyi

“…Extracellular and transmembrane proteins, which account for the products of approximately 40% of all protein-encoding genes in tumors, play a crucial role in shaping the tumor immunosuppressive microenvironment (TIME). …”
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Genotype-specific expression and NLR repertoire contribute to phenotypic resistance diversity in Plantago lanceolata by Safdari, Pezhman, Höckerstedt, Layla, Brosche, Mikael, Salojärvi, Jarkko, Laine, Anna-Liisa

“…Nucleotide-binding leucine-rich repeat (NLR) genes play an important role in pathogen recognition, downstream defense responses and defense signaling. …”
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Transient transmission of Chikungunya virus in Singapore exemplifies successful mitigation of severe epidemics in a vulnerable population by Hapuarachchi, Hapuarachchige Chanditha, Wong, Wing-Yan, Koo, Carmen, Tien, Wei-Ping, Yeo, Gladys, Rajarethinam, Jayanthi, Tan, Eugene, Chiang, Suzanna, Chong, Chee-Seng, Tan, Cheong-Huat, Tan, Li-Kiang, Ng, Lee Ching

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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Towards understanding genome regulation via high-resolution analysis of chromatin accessibility by Dai, L

“…<p>Next generation sequencing has been used to in functional genomics to rep- resent specific aspects of chromatin structure, DNA-protein interactions and the epigenome, enriching the knowledge of the non-coding genome which plays significantly roles in gene regulation but is vaguely understood. …”

The opioid receptor influences circadian rhythms in human keratinocytes through the β-arrestin pathway by Bigliardi, Paul, Junnarkar, Seetanshu, Markale, Chinmay, Lo, Sydney, Bigliardi, Elena, Kalyuzhny, Alex, Ong, Sheena, Dunn, Ray, Wahli, Walter, Bigliardi-Qi, Mei

“…The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light on the importance of the PER2 circadian clock gene as a vital antitumor gene. Furthermore, delta-opioid receptors (DOPrs) have been identified as playing a crucial role in skin differentiation, proliferation and migration, which are not only essential for wound healing but also contribute to cancer development. …”
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Identification of novel interactions between MicroRNAs and pattern-recognition receptor signalling in dentritic cells by Pichulik, T

“…</p> <p>The work in these two chapters identifies a number of novel miR-650 targets and suggests a dual role for miR-650 in the innate immune response. Firstly, it is shown that miR-650 directly regulates a group of interferon-stimulated genes with known antiviral activity. …”

Interpretable Computational Modeling of pre-mRNA Splicing for Multiple Eukaryotic Species by McCue, Kayla M.

“…In Arabidopsis, intronic and exonic SREs played comparable roles, suggesting a greater role for intronic information in plants compared with animals. …”
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Social Development / by Parke, Ross D., author 450250, Roisman, Glenn I., author 655021, Rose, Amanda J. (Amanda Janel), 1971-, author 655022, John Wiley & Sons (Online service) 647106

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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…Such mixed genotypes complicate analysis of the role of the targeted gene in the studied cell population. …”
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Deep sequencing of small RNA facilitates tissue and sex associated microRNA discovery in zebrafish by Vaz, Candida, Wee, Choon Wei, Lee, Gek Ping Serene, Ingham, Philip William, Tanavde, Vivek, Mathavan, Sinnakaruppan

“…Background: The role of microRNAs in gene regulation has been well established. …”
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Proteomic network of antibiotic-induced outer membrane vesicles released by extensively drug-resistant Elizabethkingia anophelis by Chiang, Ming-Hsien, Chang, Fang-Ju, Kesavan, Dinesh Kumar, Vasudevan, Aparna, Xu, Huaxi, Lan, Kuo-Lun, Huang, Shu-Wei, Shang, Hung-Sheng, Chuang, Yi-Ping, Yang, Ya-Sung, Chen, Te-Li

“…E. anophelis harbors multidrug resistance (MDR) genes and is intrinsically resistant to various classes of antibiotics. …”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…Chemical RNA modifications are central features of epitranscriptomics, highlighted by the discovery of modified ribonucleosides in mRNA and exemplified by the critical roles of RNA modifications in normal physiology and disease. …”
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Low magnetic field exposure alters prostate cancer cell properties by Lange, Sigrun, Inal, Jameel, Kraev, Igor, Dart, Dafydd Alwyn, Uysal-Onganer, Pinar

“…Extracellular vesicles (EVs) are crucial mediators of cellular communication with multifaceted roles in cancer progression, including via transport and uptake of various protein and microRNA (miRNA) EV-cargoes. miRNAs regulate gene expression and are implicated in cancer-related processes such as proliferation, metastasis, and chemoresistance. …”
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The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture by Eilers, Kira, Yam, Joey Kuok Hoong, Liu, Xianghui, Goh, Yu Fen, To, Ka-Ning, Paracuellos, Patricia, Morton, Richard, Brizuela, Jaime, Yong, Adeline Mei Hui, Givskov, Michael, Freibert, Sven-Andreas, Bange, Gert, Rice, Scott A., Steinchen, Wieland, Filloux, Alain

“…Complementation of the PA0285 mutant strain with a copy of the gene encoding the C-terminal GGDEF/EAL portion in trans was not as effective as complementation with the full-length gene. …”
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Heterogeneity within colorectal cancer cell lines and epigenetic regulation of CD24 by Ibn Ayub, M

“…This thesis investigated the role of methylation in dynamic regulation of CD24 based heterogeneity in colorectal cancer cell lines. …”

Layer-by-layer assembled micro and nano carriers for drug delivery applications by Mutukumaraswamy Shaillender

“…Chapter 5 describes the application of LbL technology to hydroxyapatite (HA) nanoparticles for gene delivery applications. This work investigates the integration of proteins as well as nucleic acids (pDNA) in the multilayer shells and the intracellular gene delivery. …”
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Electro spun dual structured and three-dimensional biodegradable scaffolds for bone and cartilage tissue engineering by Vidya Chamundeswari Narasimhan

“…Tissue engineering (TE) is envisaged to play a vital role in improving the quality of life by restoring, maintaining or enhancing tissue and organ functions. …”
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