Computational analysis and prediction of specific genomic regions forming R-loop structure and chromosomal variations associated with cancer by Wongsurawat, Thidathip

“…Integrative genomics analyses suggested that RLFSs could play a role in gene regulation, AID/APOBEC-mediated editing/mutagenesis, alternative splicing, and epigenetic modifications, and also associate with mutations in cancer, neurodegenerative diseases and mental disorders. …”
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Functional metagenomic analysis of quorum sensing signaling in a nitrifying community by Tan, Chuan Hao, Yeo, Yee Phan, Muhammad Hafiz Ismail, Ng, Noele Kai Jing, Subramoni, Sujatha, Taj, Shireen, Tay, Martin, Chao, Xie, Kjelleberg, Staffan, Rice, Scott A.

“…In wastewater treatment systems, acylated homoserine lactone (AHL)-based QS has been correlated with the conversion of floccular biomass into microbial granules, as well as EPS production and the nitrogen removal process. However, the role of QS in such complex communities is still not fully understood, including the QS-proficient taxa and the functional QS genes involved. …”
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Temperature induced biological alterations in the major carp, Rohu (Labeo rohita): assessing potential effects of climate change on aquaculture production by Mridul, Md. Monirul Islam, Zeehad, Md. Shariar Kabir, Aziz, Dania, Salin, Krishna R., Hurwood, David A., Rahi, Md. Lifat

“…Temperature plays a profound role in organismal growth, immunity, survival, and the entire biological systems of any aquatic species. …”
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The function of the WRI1-TCP4 regulatory module in lipid biosynthesis by Kong, Que, Yang, Yuzhou, Low, Pui Man, Guo, Liang, Yuan, Ling, Ma, Wei

“…The plant-specific TCP transcription factors play pivotal roles in various processes of plant growth and development. …”
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A transgenic zebrafish for in vivo visualization of cilia by Zhang, Hongyu, Huang, Zhuoya, Lv, Liuliu, Xin, Yuye, Wang, Qian, Li, Feng, Dong, Lina, Wu, Changxin, Ingham, Philip William, Zhao, Zhonghua

“…Overexpression of these genes, however, can affect the function of cilia, leading to artefacts in cilia studies. …”
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Identification and functional analysis of Git3 G protein-coupled receptors in Ganoderma boninense PER71 by Khairunnisa Hanisah Mohd Daud, Mohd Faizal Abu Bakar, Izwan Bharudin, Shazilah Kamaruddin, Huai, Doris Xia Quay, Farah Diba Abu Bakar, Abdul Munir Abdul Murad

“…To identify the potential genes encoded for GPCR in this fungus, intensive data mining on the genome and transcriptome data has been carried out. …”
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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…The function of mitochondria is primarily regulated by genes encoded in the mitochondrion and nucleus. Many genes on HSA21 are involved in oxidative phosphorylation (OXPHOS) and regulation of mitochondrial functions. …”
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A pilot study on peptidylarginine deiminases and protein deimination in animal cancers across vertebrate species by Inal, Jameel, Hristova, Mariya, Lange, Sigrun

“…PADs are a group of calcium-dependent enzymes that play key roles in inflammatory pathologies and have diverse roles in cancers. …”
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Effects of HSV-G47∆ oncolytic virus on telomerase and telomere length alterations in glioblastoma multiforme cancer stem cells under hypoxia and normoxia conditions by Vazifehmand, Reza, Saeed Ali, Dhuha, Monem Homaie, Foroozandeh, Molaei Jalalvand, Fatemeh, Othman, Zulkefley, Deming, Chau, Stanslas, Johnson, Sekawi, Zamberi

“…Furthermore, hTERC, DKC1, and TEP1 genes were significantly dysregulated in hypoxic and normoxic mi-croenvironments. …”

Regulation and function of innate-like T cells by Hagel, JP

“…The ability of CD161-expressing T cells to also express IL-32 upon activation was demonstrated in vitro. To elucidate the role of IL-32 in disease, a pan-cancer IL32 gene signature was generated from The Cancer Genome Atlas (TCGA) RNA-seq data. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…</p> <p>The screens were able to identify functionally relevant hits such as PTEN and INSR, which are known regulators of hepatic insulin signalling, as well as genes with a previously uncharacterised role in this pathway. …”

Effect of vitamin A on adult lung function: a triangulation of evidence approach by Mongey, R, van der Plaat, DA, Shaheen, SO, Portas, L, Potts, J, Hind, MD, Minelli, C

“…Five genes showed possible gene-vitamin A intake interactions. …”

Molecular cloning, expression, purification and crystallization of BcsG for structural analysis in escherichia coli by Lee, Jin

“…Genes such as BcsG have been found to play a crucial role in cellulose synthase formation as well and yet, little is known about BcsG apart from functional studies and theorized interaction with other Bcs proteins. …”
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Sensorimotor control of Drosophila copulation by Herbert, MR

“…</p> <p>In Drosophila, the conserved transcription factor doublesex (dsx) is required for the specification of both male and female sexual identity. One of the key roles played by dsx is regulating the development of a sexually dimorphic nervous system and recent work has shown that dsx is expressed in external mechanoreceptor neurons that adorn the male genitalia (herein termed male terminal sensilla; MTS). …”

Analysis and characterization of nervous system defects in candidate mutations resulting from a mutagenesis screen in the fruit fly, Drosophila melanogaster by Joanita Jasmen

“…In addition, attempts to disrupt the function of RNAse III enzymes gave no hint of the role of endogenous RNA interference (RNAi) in DA neuron differentiation and maintenance. …”
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Cell activation-based screening of natively paired human T cell receptor repertoires by Fahad, Ahmed S, Chung, Cheng Yu, López Acevedo, Sheila N, Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matías F, Matus-Nicodemos, Rodrigo, Laflin, Amy D, Ladi, Rukmini R, Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A, Douek, Daniel C, Balfour, Henry H, Price, David A, DeKosky, Brandon J

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Expanding the CRISPR Toolbox for Engineering Lycopene Biosynthesis in Corynebacterium glutamicum by Zhan, Zhimin, Chen, Xiong, Ye, Zhifang, Zhao, Ming, Li, Cheng, Gao, Shipeng, Sinskey, Anthony J., Yao, Lan, Dai, Jun, Jiang, Yiming, Zheng, Xueyun

“…Particularly, cg0722, a membrane protein gene, was found to play a vital role in lycopene production. …”
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The involvement of hypoxia in APOBEC-mediated mutagenesis in multiple cancers by Liang, J

“…The regulation of APOBEC genes is currently poorly understood, especially in the context of cancer. …”

Global response of Vibrio cholerae to predation by heterotrophic protists by Hu, Jie

“…Transcripts differentially expressed included biosynthetic and metabolic genes, flagellar and chemotaxis genes, genes encoding cell wall and outer membrane proteins, and transcriptional and translational regulators. …”
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Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Understanding the underlying concepts of human genetics, especially the role of genes, is important for applying genetic and genomic information as well as technologies in healthcare. …”
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