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41
The role of membrane curvature in nanoscale topography-induced intracellular signaling
Published 2019Get full text
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Journal Article -
42
Inhibitory Potential of the Truncated Isoforms on Glutamate Transporter Oligomerization Identified by Computational Analysis of Gene-Centric Isoform Maps
Published 2024“…Objective Glutamate transporters play a key role in central nervous system physiology by maintaining excitatory neurotransmitter homeostasis. …”
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Article -
43
SemFunSim : a new method for measuring disease similarity by integrating semantic and gene functional association
Published 2014“…Background Measuring similarity between diseases plays an important role in disease-related molecular function research. …”
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Journal Article -
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Screening of the PA14NR Transposon Mutant Library Identifies Genes Involved in Resistance to Bacteriophage Infection in Pseudomomas aeruginosa
Published 2024“…Functional experiments demonstrated that these genes played pivotal roles in phage adsorption and biofilm formation, indicating that altering the bacterial membrane composition commonly leads to phage resistance in P. aeruginosa. …”
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46
Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells
Published 2024“…Considering the need for temporal coordination of the cell cycle and the transcription cycle, it can be speculated that the CDKs might play a critical role in linking the two processes. Cyclin-dependent kinase 1 (CDK1) is a highly conserved essential regulator of mitosis, with recognised transcriptional functions revolving around the mitotic repression of gene expression. …”
Thesis -
47
Role of N-WASP in cell proliferation : implication for organ development and cancer
Published 2020“…Further studies will be required to elucidate the mechanisms of N-WASP in lung cancer by validating the identified gene candidates and analysing their role in cell proliferation. …”
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Thesis-Doctor of Philosophy -
48
The Response Regulator OmpR Negatively Controls the Expression of Genes Implicated in Tilimycin and Tilivalline Cytotoxin Production in Klebsiella oxytoca
Published 2025“…Our findings strongly indicate that OmpR is a repressor of the aroX and npsA genes, the first genes of aroX and NRPS operons, respectively, which are indispensable for producing these enterotoxins. …”
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50
Occurrence of the vanA and vanC2/C3 genes in Enterococcus species isolated from poultry sources in Malaysia
Published 2001“…All vancomycin-resistant E. faecalis, E. durans, E. hirae and E. faecium isolates tested by the disk diffusion assay were positive in PCR detection for presence of vanA gene. All E. casseliflavus isolates were positive for vanC2/C3 gene. …”
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Article -
51
Investigating the role of lysine demethylase UTX-1 in lifespan regulation of C. elegans
Published 2018Thesis -
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Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase
Published 2017Thesis -
54
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Published 2020“…Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2) have been previously reported to be associated with alcohol consumption. …”
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Journal Article -
55
Decoding Codon Bias: The Role of tRNA Modifications in Tissue-Specific Translation
Published 2025“…The tRNA epitranscriptome has been recognized as an important player in mRNA translation regulation. Our knowledge of the role of the tRNA epitranscriptome in fine-tuning translation via codon decoding at tissue or cell levels remains incomplete. …”
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56
Enhancement of lentiviral vector production through alteration of virus-cell interactions
Published 2016“…</p> <p>Further work will be necessary to understand the role of the inhibitory factors in lentiviral vector production, but novel cell lines in which genes encoding these factors have been permanently deleted from producer cells could lead to higher titres, reducing costs in the manufacture of lentiviral vectors and making <em>in vivo</em> gene therapy more feasible from a health economics perspective.…”
Thesis -
57
Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
Published 2024“…Critically, we demonstrate that chromatin territories expand as upregulated genes within LADs radially shift inwards. Our results indicate that the mechanism of action of B-type lamins comes from their role in constraining chromatin motion and spatial positioning of gene-specific loci, heterochromatin, and chromatin domains. …”
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Restriction analysis and sequencing of the ITS regions and 5.8S gene of rDNA of Ganoderma isolates from infected oil palm and coconut stumps in Malaysia
Published 2002“…Restriction analysis and sequencing of the ITS regions and 5.8S gene of rDNA were conducted on 53 Ganoderma isolates from infected oil palm and 15 isolates from coconut stumps to determine their relatedness. …”
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60
The role of PTEN in human bone marrow-derived mesenchymal stem cells mediated tumor cells suppression.
Published 2011“…Human bone marrow-derived mesenchymal stem cells (MSC) have been increasingly used as a vehicle for gene delivery to cancer. Still, little is known about the role of MSC in the tumor microenvironment. …”
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Final Year Project (FYP)