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1
A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases
Published 2019“…On deployment, the device swells to co-apt with the ureteric wall and ensure drug availability to these tissues. …”
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Journal Article -
2
Layer-by-layer assembled micro and nano carriers for drug delivery applications
Published 2013“…In nano- or microparticulate drug delivery, both control of the drug release and interaction of the particles with the cellular environment are critical attributes. …”
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Thesis -
3
A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence
Published 2018“…The first layer is needed for sustained release of drug while the second layer is required for close contact with urothelial wall. …”
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Thesis -
4
Characterization and evaluation of bilayer coating for enhanced localization and sustained drug delivery for fibrosis-induced ureteral stricture
Published 2016“…The usage of a bilayer coating, consisting of a hydrogel layer and a drug-loaded polymer layer, allows for direct contact with the ureter walls upon swelling and drug delivery through the urothelium. …”
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Final Year Project (FYP) -
5
Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst
Published 2022“…We demonstrate that the mode of action is due to increased inhibition of peptidoglycan cell wall biosynthesis. The findings in this study demonstrate that on-demand NIR-light activated bioorthogonal conjugation of Van to microbes is a viable alternative treatment in combating drug-resistant bacteria.…”
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Journal Article -
6
Cationic glycosylated block co-β-peptide acts on the cell wall of Gram-positive bacteria as anti-biofilm agents
Published 2021“…In addition to the emergence of resistance to last resort drugs, bacteria escape antibiotics killing by forming complex biofilms. …”
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Journal Article -
7
Identifying antifungal resistance mechanisms and modes of action using SAturated Transposon Analysis in Yeast (SATAY)
Published 2024“…These screens reveal antifungal drug targets, transporters responsible for drug uptake or efflux, as well as metabolic, signalling and trafficking pathways affecting antifungal susceptibility. …”
Thesis -
8
AI is a viable alternative to high throughput screening: a 318-target study
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Journal Article -
9
Combatting pathogenic bacteria with synthetic immunotherapeutics from chitosan: antibody recruiting at engineered bacterial surface with peptidoglycan analogs
Published 2024“…The emergence of microbial drug resistance, coupled with the paucity of new antibiotics poses an impending threat to public health. …”
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Journal Article -
10
Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study...
Published 2024“…</p> <br> <p><strong>Funding:</strong> Wellcome Trust, Bill & Melinda Gates Foundation, EU Horizon 2020, and UK National Institute for Health and Care Research.…”
Journal article -
11
Investigation of phenylpropanoid sucrose esters as antidiabetic compounds
Published 2020“…Since hybrid 77 is a systemic drug, dosing of the compound would have to account for both the rate at which it is transported across the gut wall and its toxicity. …”
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Thesis-Doctor of Philosophy -
12
Utilizing food waste and thermoplastic starch (TPS) in 3D printed PLA formulations for sustainable and customizable controlled delivery systems
Published 2024“…With the addition of TPS, the drug release profile can be adjusted from 8 – 120 hours using different TPS ratios and different printed wall thicknesses. …”
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Thesis-Master by Research -
13
Inorganic nanoparticles–driven self–assembly of natural small molecules in water for constructing multifunctional nanocapsules against plant diseases
Published 2024“…The nanocapsules effectively kill plant–pathogenic bacteria via tight binding to the bacterial surface, inducing reactive oxygen species accumulation and disrupting bacterial cell walls. ZnO@Cur@PDA display strong activities against rice bacterial blight with protective activity of 64.0 % and curative activity of 62.2%, which is much better than commercial drugs bismerthiazol (protective activity of 33.0 % and curative activity of 38.4%) and zinc thiazole(protective activity of 38.6 % and curative activity of 31.8%). …”
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Journal Article -
14
Methods for the Study of Galactofuranose in Mycobacteria
Published 2024“…However, it is conspicuously absent from human cells, thus establishing its biosynthetic pathways as important potential drug targets. Our knowledge about the biological roles of galactofuranose in cells is hampered by a dearth of methods by which to study it. …”
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Thesis -
15
Construction and characterization of a Lactococcus lactis in-trans surface display system harboring murine glycosylated tyrosinase related protein-2
Published 2015“…The Generally Regarded as Safe (GRAS) status of LAB such as Lactococcus lactis coupled with non-recombinant strategy of in-trans surface display system, provide a safe platform for therapeutic drug and vaccine development. However, therapeutic proteins fused with cell-wall anchoring motif production are predominantly limited to prokaryotic expression system. …”
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Thesis -
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Thermal effects on particle deposition in microchannels
Published 2016“…Transport and interactions of colloidal particles and biomolecules in microchannels are of great importance to many microfluidic applications, such as drug delivery in life science, microscale heat exchangers in electronic cooling, food processing industry etc. …”
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Thesis