Effect of antimicrobial agents on biofilm cells and invitro development of resistance in planktonic cells of pseudomonas aeruginosa PA01 by Balasankar Meera Priyadarshini

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The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…However, the therapeutic response to ionising radiation is greatly dependent on the oxygenation status of the tumour. Hypoxic tumours are well-established to have association with malignant progression and radioresistance. …”
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Investigating the genetics and immunopathogenesis of ankylosing spondylitis by Liu, F

“…I hypothesized that studying the common genetic risks among AS and its associated conditions could help prioritize risk genes as potential drug targets and reveal potential opportunities for drug repurposing. …”

Settling velocity of a porous object by Muhammad Khalil Khaidir

“…The settling experiments were conducted under different fluid viscosities and a curve was plotted which relates Drag Coefficient (CD) with Reynolds Number (Re) and porosity. …”
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Effect of size on degradation and different fabrication methods for nano particles by Loh, Eugenia Mei Ting.

“…Poly (lactic-co-glycolic acid), also known as PLGA, is commonly used to encapsulate drugs for drug delivery purpose in the form of micro size particles as well as nano order particles. …”
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US exceptionalism? International trends in midlife mortality by Dowd, JB, Doniec, K, Zhang, L, Tilstra, A

“…We provide a synthesis of cause-specific mortality trends in midlife (25–64 years of age) for the USA and the UK as well as other high-income and Central and Eastern European (CEE) countries.…”

Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca²⁺ defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”

Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities by Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei

“…Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.…”
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Computational investigations of HIV-1 protease and protease inhibitors interactions by Sham, Hoi Fung

“…Studies of the interactions between the HIV protease and PIs are thus essential for effective drug design. In this project, an investigation of the interactions between the HIV type 1 (HIV-1) protease and PIs was carried out. …”
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Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…This establishes the potential of L1 as a Nurr1-activating drug and lays the foundation for future development of disease-modifying drugs for PD to prevent or slow down its progression.…”
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Isolation and characterization of extracellular vesicles and future directions in diagnosis and therapy by De Sousa, Karina P., Rossi, Izadora, Abdullahi, Mahamed, Ramirez, Marcel I., Stratton, Dan, Inal, Jameel

“…With interest in therapeutic applications of EVs growing, we address fundamental points of EV-related cell biology, such as cellular uptake mechanisms and their biodistribution in tissues as well as challenges to their application as drug carriers or biomarkers for less invasive diagnosis or as immunogens.…”
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Synthesis of densely functionalized pyrroles from unprotected carbohydrates by Xia, Mengxin

“…The activity of pyrrole-based drugs is tuned with the type of substituents on the pyrrole core and on the substitution pattern on the core pyrrole ring. …”
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Multi-Modal Protein Function Prediction using a Joint Embedding Space from Two Graph Neural Networks by Tysinger, Emma P.

“…We present a multi-modal framework using two graph neural networks to infer a joint embedding space that captures many properties of a protein including structure, disease associations, drug interactions, protein interactions, biological processes and more. …”
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Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology by Shinozuka, K, Jerotic, K, Mediano, P, Zhao, AT, Preller, KH, Carhart-Harris, R, Kringelbach, ML

“…This suggests an urgent need for standardising experimental procedures and analysis techniques, as well as for more research on the emergence between different levels of psychedelic effects.…”

Antimicrobial efficacy testing of antibiotic-containing biodegradable nanopolymers against biofilm and planktonic cells. by Polimyr Caesar Dave Pelisco Dingal.

“…With efficient use of drug-encapsulated nanopolymers, bactericidal dosages are sufficiently lowered and dosing intervals can be extended due to the sustained drug release feature afforded by these efficacious nanocarriers.…”
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A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications by Chen, Xiao, Li, Hua, Lam, King-Yeung

“…The electrical and pH response characteristics of the hydrogel, especially those in neutral solution, may inspire some potential biomedical applications, such as photo-controlled drug release and cell growth.…”
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Production of single-chain variable fragment epidermal growth factor receptor (scFv-EGFR) antibody by Loh, Valerie Kai Li.

“…The antibody product is meant to bind to EGFRs and has diagnostic and potential therapeutic applications, for instance, conjugating to a carrier for drug delivery purposes. Initially, optimization of yield was attempted via use of different induction strategies, coupled with the use of various expression systems, including the use of commercially available pET vectors and BL21 host strain derivatives that have been well-published. …”
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Injectable hydrogels as matrix to retain microparticles for controlled delivery of anti-VEGF proteins for ocular applications by Chong, Wei Woon

“…Chitosan-oxidized alginate was developed to serve as a matrix to carry Eylea® loaded chitosan microparticles, preventing an initial large burst of drugs and achieving a controlled drug release. Firstly, chitosan-oxidized alginate hydrogel was produced by chemically crosslinking glycol chitosan with oxidized alginate of varying degree of oxidation. …”
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Understanding droplet jetting on varying substrate for biological applications by Lee, Jia Min, Huang, Xi, Goh, Guo Liang, Tran, Tuan, Yeong, Wai Yee

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