Assessing long-term effectiveness and cost-effectiveness of statin therapy in the UK: a modelling study using individual participant datasets by Mihaylova, B, Wu, R, Zhou, J, Williams, C, Schlackow, I, Emberson, J, Reith, C, Keech, A, Robson, J, Parnell, R, Armitage, J, Gray, A, Simes, J, Baigent, C

“…UK primary and hospital care data informed healthcare costs (2020/2021 UK£); £1.22 standard or £1.68 higher intensity generic statin therapy per 28 tablets; and Health Survey for England data informed health-related quality of life. …”

Physiological stress responses and meat quality of rabbits subjected to different road transportation and slaughter methods by Khadijah, Nakyinsige

“…All in all, the present study has shown than that transport and slaughter caused substantial physiological stress responses, and even though these may not necessarily translate into compromising of animal welfare, care must be taken to avoid reaching the threshold to negatively affect meat quality. …”
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Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures by Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J. Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., Goya-Maldonado, Roberto

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An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study by Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J. M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., Hart, Leen M. 't, van de Wiel, Mark A., Beulens, Joline W. J.

“…Results: Of the 585 individuals from the Hoorn Diabetes Care System (DCS) cohort, 69 required insulin during follow-up (1.0–11.4 years); of the 571 individuals in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) cohort, 175 required insulin during follow-up (0.3–11.8 years). …”
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Strategies to modulate Amorphous Oxide Semiconductor properties for low temperature transparent transistors by Kulkarni, Mohit Rameshchandra

“…The prospect of athermal annealing with the inclusion of a reducing oxide layer carefully chosen from the Ellingham diagram used as an overlayer on the semiconducting oxide layer was also explored. …”
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Accelerated discovery of new catalysts for oxygen evolution reaction by Mahmoud G. Ahmed

“…The third metal ion is carefully selected based on its electronic configuration to see whether the electronic configuration of ternary oxide can be regulated for enhanced OER performance. …”
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Understanding the role of Enterococcus faecalis in polymicrobial wounds by Davient, Bala

“…Evaluating wound healing parameters next in E. faecalis-positive polymicrobial wounds will unveil if the species can be of utility in chronic wound healing, circumventing the need for wound debridement and antibiotics, and thereby reducing the cost of chronic wound care through personalized wound therapy.…”
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Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John Campbell, Kooner, Jaspal S., Scott, William R.

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Towards electrically injected colloidal semiconductor lasers by Thung, Yi Tian

“…Overcoming this requires careful selection of nanocrystals as gain media, a resonant optical cavity supporting low lasing thresholds and high optical gain, and an architecture suitable for high electrical injection currents to achieve population inversion for lasing. …”
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Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…</p> <br> <p><strong>Funding:</strong> The European and Developing Countries Clinical Trials Partnership; the UK Medical Research Council; the UK Department for International Development; the National Institute for Health and Care Research Oxford Biomedical Research Centre; the Division of Intramural Research, National Institute of Allergy and Infectious Diseases; the US Agency for International Development; and the Wellcome Trust.…”

Towards robust sensing and recognition : from statistical learning to transfer learning by Yang, Jianfei

“…Secondly, current domain adaptation methods require careful manual hyper-parameter tuning, which is not realistic for unmanned systems such as smart cars. …”
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Differences in the effectiveness of individual-level smoking cessation interventions by socioeconomic status by Theodoulou, A, Fanshawe, TR, Leavens, E, Theodoulou, E, Wu, AD, Heath, L, Stewart, C, Nollen, N, Ahluwalia, JS, Butler, AR, Hajizadeh, A, Thomas, J, Lindson, N, Hartmann-Boyce, J

“…There was very low‐certainty evidence of no difference in quit rates by SES for face‐to‐face counselling compared to less intensive counselling, balanced components, or usual care. However, the CI included the possibility of favouring lower and higher SES groups (ROR 1.26, 95% CI 0.18 to 8.93; from 1 of 6 studies, 294 participants; 5 studies reported no difference), indicating a possibly neutral impact. …”

Electronic cigarettes for smoking cessation by Lindson, N, Butler, AR, McRobbie, H, Bullen, C, Hajek, P, Wu, AD, Begh, R, Theodoulou, A, Notley, C, Rigotti, NA, Turner, T, Livingstone-Banks, J, Morris, T, Hartmann-Boyce, J

“…Evidence comparing nicotine EC with usual care or no treatment also suggests benefit, but is less certain due to risk of bias inherent in the study design. …”

Interventions for smoking cessation in hospitalised patients by Streck, JM, Rigotti, NA, Livingstone-Banks, J, Tindle, HA, Clair, C, Munafò, MR, Sterling-Maisel, C, Hartmann-Boyce, J

“…<p><b>Objectives</b></p> To assess the effects of any type of smoking cessation programme for patients admitted to an acute care hospital. <p><b>Search methods</b></p> We used standard, extensive Cochrane search methods. …”

Electronic cigarettes for smoking cessation by Lindson, N, Butler, AR, McRobbie, H, Bullen, C, Hajek, P, Begh, R, Theodoulou, A, Notley, C, Rigotti, NA, Turner, T, Livingstone-Banks, J, Morris, T, Hartmann-Boyce, J

“…Evidence comparing nicotine EC with usual care/no treatment also suggests benefit, but is less certain due to risk of bias inherent in the study design. …”

Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Bhattacharjee, NV, Schumacher, AE, Aali, A, Almidani, O, Bandyopadhyay, S, Graham, SM, Lacey, BWH, Maude, RJ, Runghien, T, Rodriguez, JAB

“…Estimates and projections of fertility are necessary to inform policies involving resource and health-care needs, labour supply, education, gender equality, and family planning and support. …”

Tsewang Norbu NGB by Cantwell, C, Mayer, R

“…Given the recent near destruction of the entire rNying ma'i rgyud 'bum corpus, coupled with the fact that we often find numerous and substantial variants in rNying ma'i rgyud 'bum texts both transmissional (unwitting changes by copyists) and recensional (deliberate changes by editors), all editions are now invaluable sources for any research on this religious tradition, or, indeed, to any efforts to render these texts fully readable once more through careful textual editing. The well-written and attractively presented Rig 'dzin Tshe dbang nor bu edition manuscripts are thus of great significance to the preservation of the whole rNying ma Tantric tradition, and it is our hope that our work in cataloguing them, among other things made with future text-critical concerns in mind, will enable future scholarship in this field to progress.…”