Sequence‐Sensitivity in Functional Synthetic Polymer Properties by Jin, Tianyi, Coley, Connor W, Alexander‐Katz, Alfredo

“…Their function appears to be insensitive to the precise sequence. Here, through atomistic molecular dynamics simulation, we show that there are universal protein‐like features of MMA‐based RHPs that are insensitive to the sequence, and mostly depend on the overall composition. …”
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Can we achieve atmospheric chemical environments in the laboratory? An integrated model-measurement approach to chamber SOA studies by Kenagy, Hannah S, Heald, Colette L, Tahsini, Nadia, Goss, Matthew B, Kroll, Jesse H

“…Because many SOA model descriptions are derived from environmental chamber experiments, our ability to represent atmospheric conditions in chambers directly affects our ability to assess the air quality and climate impacts of SOA. Here, we develop an approach that leverages global modeling and detailed mechanisms to design chamber experiments that mimic the atmospheric chemistry of organic peroxy radicals (RO2), a key intermediate in VOC oxidation. …”
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Marsh restoration in front of seawalls is an economically justified nature-based solution for coastal protection by Lee, Ernie IH, Nepf, Heidi

“…However, we still have a limited understanding of how to quantify the marsh wave attenuation benefits for economic analysis. Here, we incorporate a prediction of wave attenuation that accounts for species-specific morphology and structural stiffness into a 1-D wave model and validate it with field measurements. …”
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Cell activation-based screening of natively paired human T cell receptor repertoires by Fahad, Ahmed S, Chung, Cheng Yu, López Acevedo, Sheila N, Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matías F, Matus-Nicodemos, Rodrigo, Laflin, Amy D, Ladi, Rukmini R, Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A, Douek, Daniel C, Balfour, Henry H, Price, David A, DeKosky, Brandon J

“…Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective human T cell receptors (TCRs). Here we present a high-throughput approach to the identification of natively paired human TCRα and TCRβ (TCRα:β) genes encoding heterodimeric TCRs that recognize specific peptide antigens bound to major histocompatibility complex molecules (pMHCs). …”
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Simultaneous Measurements of Actin Filament Turnover, Filament Fraction, and Monomer Diffusion in Endothelial Cells by McGrath, J. L., Tardy, Y., Dewey, C. F. Jr, Meister, J. J., Hartwig, J. H.

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Intrinsic nanofilamentation in resistive switching by Migas, Dmitri B., Borisenko, Victor E., Wu, Xing, Cha, Dongkyu, Bosman, Michel, Raghavan, Nagarajan, Zhang, Xi Xiang, Li, Kun, Pey, Kin Leong

“…Intensive studies have been carried out on sandwiched metal-insulator-metal structures to achieve high density on-chip circuitry and non-volatile memory storage. Here, we provide insight into the mechanisms that govern highly reproducible controlled resistive switching via a nanofilament by using an asymmetric metal-insulator-semiconductor structure. …”
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Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling by Witmer, Kathrin, Schmid, Christoph D., Brancucci, Nicolas M. B., Luah, Yen-Hoon, Preiser, Peter Rainer, Bozdech, Zbynek, Voss, Till S.

“…PfEMP1 undergoes antigenic variation through switches in mutually exclusive var gene transcription. var promoters function as crucial regulatory elements in the underlying epigenetic control strategy. Here, we analysed promoters of upsA, upsB and upsC var, rifA1-type rif, stevor, phist and pfmc-2tm genes and investigated their role in endogenous gene transcription by comparative genome-wide expression profiling of transgenic parasite lines. …”
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An efficient image formation algorithm for real-time linear-array photoacoustic tomography by Mozaffarzadeh, Moein, Periyasamy, Vijitha, Upputuri, Paul Kumar, Pramanik, Manojit, Makkiabadi, Bahador

“…However, the reconstructed image is a ected by noise and artifacts. Here, we investigate the performance of a nonlinear (NL) beamforming method for linear-array PA image formation. …”
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Droplet optofluidic imaging for λ-bacteriophage detection via co-culture with host cell Escherichia coli by Yu, J. Q., Huang, W., Chin, L. K., Lei, L., Lin, Z. P., Ser, W., Chen, H., Ayi, T. C., Yap, P. H., Chen, C. H., Liu, A. Q.

“…Previously, bacteriophage detection was based on a plague assay that required a complicated labelling technique and a time-consuming culture assay. Here, for the first time, a label-free bacteriophage detection is reported by using droplet optofluidic imaging, which uses host-cell-containing microdroplets as reaction carriers for bacteriophage infection due to a higher contact ratio. …”
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Book Mavens of Manila : an interpretative phenomenological analysis of contemporary niche publishers in the Philippines by Sagun, Karryl Kim Abella

“…Chapter Seven, the third study, probes the experiences of self-publishers. Here I found that not all authors are created equal—some are able to self-publish both in print and electronically, some just online, while some are still controlled by a traditional publisher. …”
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Next-generation transgenic mice for optogenetic analysis of neural circuits by Feng, Guoping, Asrican, Brent, Augustine, George J., Berglund, Ken, Chen, Susu, Chow, Nick, Gloss, Bernd, Deisseroth, Karl, Mancuso, James, Hira, Riichiro, Hoffmann, Carolin, Tan, Gregory, Kasai, Haruo, Katarya, Malvika, Kim, Jinsook, Kudolo, John, Lee, Li Ming, Lo, Shun Qiang, Matsuzaki, Masanori, Nakajima, Ryuichi, Qiu, Li, Tang, Yanxia, Ting, Jonathan T., Tsuda, Sachiko, Wen, Lei, Zhang, Xuying, Zhao, Shengli

“…Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. …”
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Manganese doped fluorescent paramagnetic nanocrystals for dual-modal imaging by Sharma, Vijay Kumar, Gokyar, Sayim, Kelestemur, Yusuf, Erdem, Talha, Unal, Emre, Demir, Hilmi Volkan

“…It is observed that with increasing Mn2+ concentration the PL intensity first increases, reaching a maximum at Mn2+ concentration of 3.2 at% (achieving a PL quantum yield (QY) of 37%), after which it starts to decrease. Here, this high-efficiency sample is demonstrated for applications in dual-modal imaging. …”
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Precision synthesis : designing hot spots over hot spots via selective gold deposition on silver octahedra edges by Hegde, Ravi S., Tjiu, Weng Weei, Cui, Yan, Ling, Xing Yi, Liu, Yejing, Pedireddy, Srikanth, Lee, Yih Hong

“…A major challenge in plasmonic hot spot fabrication is to efficiently increase the hot spot volumes on single metal nanoparticles to generate stronger signals in plasmon-enhanced applications. Here, the synthesis of designer nanoparticles, where plasmonic-active Au nanodots are selectively deposited onto the edge/tip hot spot regions of Ag nanoparticles, is demonstrated using a two-step seed-mediated precision synthesis approach. …”
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Nitric oxide : a key mediator of biofilm dispersal with applications in infectious diseases by Barraud, Nicolas, Kelso, Michael J., Rice, Scott A., Kjelleberg, Staffan

“…Recently, the simple gas and ubiquitous biological signaling molecule nitric oxide (NO) was identified as a key mediator of biofilm dispersal conserved across microbial species. Here, we review the role and mechanisms of NO mediating dispersal in bacterial biofilms, and its potential for novel therapeutics. …”
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Nanoconfined β-sheets mechanically reinforce the supra-biomolecular network of robust squid sucker ring teeth by Guerette, Paul A., Hoon, Shawn, Ding, Dawei, Amini, Shahrouz, Masic, Admir, Ravi, Vydianathan, Venkatesh, Byrappa, Weaver, James C., Miserez, Ali

“…The predatory efficiency of squid and cuttlefish (superorder Decapodiformes) is enhanced by robust Sucker Ring Teeth (SRT) that perform grappling functions during prey capture. Here, we show that SRT are composed entirely of related structural “suckerin” proteins whose modular designs enable the formation of nanoconfined β-sheet-reinforced polymer networks. …”
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Lithium intercalation compound dramatically influences the electrochemical properties of exfoliated MoS2 by Ambrosi, Adriano, Sofer, Zdeněk, Pumera, Martin

“…Organolithium compounds are generally adopted for the Li intercalation with n-butyllithium (n-Bu-Li) being the most common. Here, the use of three different organolithium compounds are investigated and compared, i.e., methyllithium (Me-Li), n-butyllithium (n-Bu-Li) and tert-butyllithium (t-Bu-Li), used for the exfoliation of bulk MoS2. …”
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A versatile light-switchable nanorod memory : Wurtzite ZnO on perovskite SrTiO3 by Bera, Ashok, Peng, Haiyang, Lourembam, James, Shen, Youde, Sun, Xiaowei, Wu, T.

“…Integrating materials with distinct lattice symmetries and dimensions is an effective design strategy toward realizing novel devices with unprecedented functionalities, but many challenges remain in synthesis and device design. Here, a heterojunction memory made of wurtzite ZnO nanorods grown on perovskite Nb-doped SrTiO3 (NSTO) is reported, the electronic properties of which can be drastically reconfigured by applying a voltage and light. …”
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PI3K-C2α knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation by Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Yunn, Na-Oh, Lim, Jong Hoon, Ryu, Sung Ho, Pereira, Teresa, Berggren, Per-Olof, Leibiger, Ingo B.

“…A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant in one biological function and insulin sensitive in another at the same time. Here, we provide evidence that in pancreatic β cells, knockdown of PI3K-C2α expression results in rerouting of the insulin signal from insulin receptor (IR)-B/PI3K-C2α/PKB-mediated metabolic signaling to IR-B/Shc/ERK-mediated mitogenic signaling, which allows the β cell to switch from a highly glucose-responsive, differentiated state to a proliferative state. …”
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New insight Into a volcanic system : analogue investigation of bubble-driven deformation in an elastic conduit by Manta, Fabio, Emadzadeh, Adel, Taisne, Benoit

“…Our results show that the combination of an elastic conduit with a large volume of gas may lead to the development of a new type of slug, here defined as a “super slug,” characterized by tapering towards the tail and a much higher ascent velocity and inner pressure compared with ordinary slugs. …”
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Preparation of 1T′-phase ReS2xSe2(1‑x) (x = 0−1) nanodots for highly efficient electrocatalytic hydrogen evolution reaction by Lai, Zhuangchai, Chaturvedi, Apoorva, Wang, Yun, Tran, Thu Ha, Liu, Xiaozhi, Tan, Chaoliang, Luo, Zhimin, Chen, Bo, Huang, Ying, Nam, Gwang-Hyeon, Zhang, Zhicheng, Chen, Ye, Hu, Zhaoning, Li, Bing, Xi, Shibo, Zhang, Qinghua, Zong, Yun, Gu, Lin, Kloc, Christian, Du, Yonghua, Zhang, Hua

“…As a source of clean energy, a reliable hydrogen evolution reaction (HER) requires robust and highly efficient catalysts. Here, by combining chemical vapor transport and Li-intercalation, we have prepared a series of 1T′-phase ReS2xSe2(1-x) (x = 0–1) nanodots to achieve high-performance HER in acid medium. …”
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