The role of CD1a in dengue infection by Yang, J

“…To investigate the effect of dengue infection on the function of CD1a-reactive T cells, polyclonal blood T cells from patients and controls, and CD1a-autoreactive T cells clone/lines were utilised. The production of IFN-γ and GM-CSF by CD1a-autoreactive T cells was reduced when co-cultured with dengue-infected presenting cells. …”

Development of coherent detector technologies for sub-millimetre wave astronomy observations by Tan, B-K

“…</p> <p>Using the current 16-pixel 350 GHz SIS receiver, HARP-B, we have observed the ¹²CO J=3→2 emission lines from two nearby galaxies. An important result we found is that the ¹²CO J=3→2 correlates strongly with the 8 μm Polycyclic Aromatic Hydrocarbon emission.…”

Structure and inhibition of novel cyclin-dependent kinases by Dixon-Clarke, S

“…Preliminary trials using these relatively non-selective compounds to inhibit CDK16 in melanoma and medulloblastoma cancer cell lines revealed rebastinib as the more efficacious drug causing loss of cell proliferation in the 1-2 micromolar range. …”

Dwelling encounters: migration, diversity and ambivalence in an Istanbul neighborhood by Biehl, K

“…In this dissertation I apply a novel theoretical approach drawing on the concept of dwelling for understanding how residents of Kumkapı relate to their environment and make sense of it. I propose three lines of argument that unfold sequentially through the organizing structure of the thesis. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps, an... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, K

“…Steady and unsteady casing static pressure measurements were acquired, using pneumatic lines and high-frequency response (∼100 kHz) Kulite pressure transducers, respectively. …”

Key transcriptional regulators of neutrophil function in inflammation by Ai, Z

“…</p> <p>To investigate the regulatory role of the selected TFs in neutrophils, I utilised HoxB8 myeloid progenitors as a model system for in vitro production of neutrophils and generated stable knockout lines for JUNB, RELB, IRF5, RFX2, KLF6, and RUNX1 in Hoxb8 myeloid progenitors, using the CRISPR/Cas9 mediated system. …”

BRCA1 regulation of breast cancer cell motility by Hernandez Nuñez, ZE

“…Time-lapse microscopy of breast cancer cell lines with various BRCA1 backgrounds was employed to evaluate the impact of inhibiting ubiquitin ligase activity. …”

How are cognitive maps formed and encoded in humans? by Glitz, L

“…In Chapter 4, we find evidence for the latter, with trajectory training resulting in neural encoding of the map that is more similar to separate transitive lines along rows and columns, the extent of which is related to behavioural accuracy. …”

Nanoparticles enhanced laser-induced breakdown spectroscopy for characterisation and discrimination of gemstones by Al-Juboori, Haider, Haider, Zhaib, Hang, Wei, Roslan, Sufi

“…Results have shown a significant enhancement in spectral features, i.e., the emergence of several new spectral lines of major gemstone elements in the UV-Vis regions of the NELIBS spectra, while the CLIBS spectra were devoid of any meaningful spectral information. …”
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Current evidence and future direction on evaluating the anticancer effects of curcumin, gingerols, and shogaols in cervical cancer: a systematic review by Rahim, Unwaniah Abdull, Mustapa, Marami, Mohamed Shakrin, Nik Noorul Shakira, Nurdin, Armania, Mohamad Taridi, Nursiati, Mohd Yusof, Yasmin Anum, Mad Nordin, Mariam Firdhaus, Che Roos, Nur Aishah

“…Only studies investigating the effects of curcumin, gingerol, shogaol, and/ or their combination in human cervical cancer cell lines and/or rodent animal models implanted with cervical cancer xenografts were included. …”
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Synthetic, spectroscopic, biological and X-ray crystallographic structural studies on a novel pyridine-nitrogen-bridged dimeric nickel(II) complex of a pentadentate N3S2 ligand by Akbar Ali, Mohammad, Mirza, Aminul Huq, Butcher, Ray J., Tarafder, M.T.H.

“…The anticancer properties of these compounds were also evaluated against Human T-lymphoblastic leukaemia cell lines. The Schiff base exhibits marked cytotoxicity against these cells, but its nickel(II) complex is inactive.…”
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Energy storage management for renewable energy systems by Feng, Xue

“…Compared with two conventional methods, the proposed control method for the HES demonstrates improved efficiency of involving the ultracapacitors to handle power spikes while protecting batteries from misuse. …”
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Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Glob... by Naghavi, M, Ong, KL, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, R, Dolecek, C, Lacey, BWH

“…These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. …”

Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

“…We show that human MM cell lines (RPMI8226, MM.1S, KMS20, and AMO1) increase dry mass upon bortezomib treatment. …”
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Bursting on a vortex tube with initial axial core-size perturbations by Ji, Lingbo, Van Rees, Wim M.

“…To further assess the relevance and prevalence of bursting in practical settings, subsequent investigations in the stability and sensitivity of our results to varying Reynolds number, nonrectilinear vortex center lines, and external strain fields are needed.…”
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A low-cost, open-source cylindrical Couette rheometer by Erni, Makita, Hart, A. John, Trumper, David, Owens, Crystal E.

“…As a result, rheometers are typically large, expensive, and require additional infrastructure (e.g., gas lines), rendering them inaccessible for regular use by many individuals, small organizations, and educators. …”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…METTL8, however, modified only mRNA, as determined by biochemical and genetic analyses in Mettl8 null-mutant mice and two human METTL8 mutant cell lines. Our findings provide the first evidence of the existence of m3C modification in mRNA, and the discovery of METTL8 as an mRNA m3C writer enzyme opens the door to future studies of other m3C epitranscriptomic reader and eraser functions.…”
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Holocene rate of slip and tentative recurrence interval for large earthquakes on the San Andreas fault, Cajon Pass, southern California by Sieh, Kerry, Weldon, Ray J.

“….; it has provided tentative evidence for 6 earthquakes in about the past 1,000 yr. Both lines of evidence suggest an average recurrence interval for large earthquakes of ∼1½ to 2 centuries. …”
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Who learns when workers are trained? a case of safety training of maintenance contractors’ workers for a major petrochemical plant shutdown by A., Fakhru'l-Razi, S.E., Iyuke, M.B., Hassan, M.S., Aini

“…The curves obtained are typical for the whole exercise, which gave perfect straight lines for Introduction to Safety, Hydrogen Sulphide, Confine Space and Permit to Work, respectively. …”
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A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…</p> <p>Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical testing studies have been carried out in non-cardiac cell lines, heterogeneous cardiac populations or animal models that have been unable to accurately represent human cardiomyocyte physiology. …”