Determination of octreotide acetate as radiosensitizer in breast cancer cell lines by Alkhansa, Salih Mahmoud Abdalla

“…While MCF7 cell line was resistant to radiation, there was no difference between the irradiated and non-irradiated cells, however, SSTR1, SSTR2, SSTR3 and SSTR4 mRNA expression were significantly higher in MDA-MB231 cell line as compared to MCF-7 cell line (P=0.02, 0.002, 0.001, 0.01) respectively. These findings showed that MCF7 is a radio- resistant cell line expressed low levels of SSTRs 1-5 which considered a suitable model for study the effects of octreotide acetate agonist as radiosensitizer in breast cancer. …”
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Enhanced rice (Oryza sativa L.) plant growth and nutrient contents during the vegetative stage through zinc solubilizing bacterial bead inoculation by Ramly, Irsyad Sulaimi, Othman, Nur Maizatul Idayu, Shamsuddin, Aida Soraya, Zuan, Ali Tan Kee, Zakaria, Nor Hafizah, Abdul Majid, Fadzilah Adibah, Hamid, Nur’ Amira

“…Mixed inoculant also improved soil fertility by increasing the available Zn (6.17 mg kg-1) in the soil, however, it lowered the soil pH to pH 5.8. These findings highlight the potential of ZSB, particularly A. nosocomialis (SR R-10), to improve rice plant’s growth and nutritional quality and increase the bioavailability of zinc in the soil to promote sustainable agricultural practices.…”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…It is suggested that the anticancer effect of the M.indica extract is via modulation of redox status through its antioxidant constituents and induction of apoptosis. These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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Tea leaf [Camellia sinensis (L.) Kuntze] extract-synthesized silver nanoparticles as antimicrobial agent against foodborne pathogens by Loo, Yuet Ying

“…This is the first report to demonstratethat the application of AgNPs in washing-up liquid has significant antibacterial activity against foodborne pathogens. Overall, the findings show that AgNPs have strong antibacterial activity and can be an alternative antimicrobial agent.…”
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Development of superhydrophobic ceramic membrane decorated with flake-like structure by two-step synthesis for seawater desalination by membrane distillation by Omar, Najib Meftah Almukhtar, Othman, Mohd. Hafiz Dzarfan, Tai, Zhong Sheng, Puteh, Mohd. Hafiz, Wong, Keng Yinn, Tan, Huiyi, Tonni Agustiono Kurniawan, Tonni Agustiono Kurniawan, Ooi, Boon Seng, Nomura, Mikihiro, Iwamoto, Yuji

“…A seawater desalination experiment by a membrane distillation (MD) system evaluated the performance of MK-SS HFM for 500 min. Significant findings: The results revealed that the MK-SS/4 h HFM, characterized by its flake-like structure, exhibited optimal superhydrophobic behavior. …”

Machine learning, IoT and 5G technologies for breast cancer studies: A review by Saroğlu, Havva Elif, Shayea, Ibraheem, Saoud, Bilal, Azmi, Marwan Hadri, El-Saleh, Ayman A., Saad, Sawsan Ali, Mohammad Alnakhli, Mohammad Alnakhli

“…The present study aims to examine various classifiers utilized in ML and DL methodologies for the purpose of diagnosing BC. Research findings have demonstrated that DL has superior performance compared to standard ML methods in the context of BC diagnosis, particularly when the dataset is extensive. …”
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Towards the Realization of National Automotive Policy (NAP): Modelling the Malaysian Consumers’ Purchase Behavioral Intention towards Energy Efficient Vehicles (EEVs) (S/O 14165) by Mohd Noor, Nor Azila, Mohd Fadhil, Faudziah Hanim, Md Isa, Filzah, Salleh, Hayatul Safrah, Muhammad, Azli

“…Consumers’ attitudes mediate the relationships between functional value, emotional value and novelty value and consumers’ behavioural intention to purchase energy efficient vehicle. The findings of this study show that brand preference does not perform any moderating role on the relationship between consumers’ attitudes and purchase behavioural intention, which means that brand preference has no influence on association between consumers’ attitudes and purchase behavioural intention. …”
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Agarwood oil grade clustering of aquilaria malaccensis species using Extraction by GC-MS analysis: Efficient KNN algorithm based on patterns visualization of two-dimensional graph by Siti Mariatul Hazwa, Mohd Huzir, Anis Hazirah ‘Izzati H., Al-Hadi, Amir Hussairi, Zaidi, Nurlaila F., Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood oil sample data were categorized into low, medium-low, medium-high and high grades. The findings show that KNN yielded 100% accuracy. Then, 2D graph was applied to plot the sample visualization pattern parallel with KNN accuracy. …”
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Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System by Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R

“…Kupffer cell–mediated cytokine release recapitulated an in vivo proinflammatory response exemplified by a cohort of 11 cytokines that were differentially regulated after lipopolysaccharide induction, including interleukin (IL)-1β, IL-1Ra, IL-6, IL-8, IP-10, tumor necrosis factor-α, RANTES (regulated on activation normal T cell expressed and secreted), granulocyte colony-stimulating factor, macrophage colony-stimulating factor, macrophage inflammatory protein-1β, and IL-5. In summary, our findings indicate that three-dimensional liver microphysiological systems may serve as preclinical investigational platforms from the perspective of the discovery of a set of clinically relevant biomarkers including potential reactive metabolites, endogenous bile acids, excreted proteins, and cytokines to predict early drug-induced liver toxicity in humans.…”
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Food environments and obesity: a geospatial analysis of the South Asia Biobank, income and sex inequalities by Atanasova, Petya, Kusuma, Dian, Pineda, Elisa, Anjana, Ranjit Mohan, De Silva, Laksara, Hanif, Abu A. M., Hasan, Mehedi, Hossain, Md Mokbul, Indrawansa, Susantha, Jayamanne, Deepal, Jha, Sujeet, Kasturiratne, Anuradhani, Katulanda, Prasad, Khawaja, Khadija I., Kumarendran, Balachandran, Mrida, Malay K., Rajakaruna, Vindya, Chambers, John Campbell, Frost, Gary, Sassi, Franco, Miraldo, Marisa

“…Multivariate regression models were used to assess association of exposure to healthy and unhealthy food environments on waist circumference, BMI, and probability of obesity for the total sample and stratified by sex and income. Findings: The presence of a higher share of supermarkets in the neighbourhood was associated with a reduction in body size (BMI, β = - 3∙23; p < 0∙0001, and waist circumference, β = −5∙99; p = 0∙0212) and obesity (Average Marginal Effect (AME): −0∙18; p = 0∙0009). …”
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Growth hormone increases BDNF and mTOR expression in specific brain regions after photothrombotic stroke in mice by Sanchez-Bezanilla, Sonia, Beard, Daniel J., Hood, Rebecca J., Åberg, N. David, Crock, Patricia, Walker, Frederick R., Nilsson, Michael, Isgaard, Jörgen, Ong, Lin Kooi

“…Upregulation of total-mTOR protein expression in the peri-infarct and thalamus suggests that this might be a pathway that is involved in the neurorestorative effects previously reported in these animals and warrants further investigation. These findings suggest region-specific mechanisms of action of GH treatment and provide further understanding for how GH treatment promotes neurorestorative effects after stroke.…”
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Foot care behaviours and associated factors among patients with type 2 diabetes: a cross-sectional study by Ang, Chin-Siang, Goh, Kelley Fann Ing, Lodh, Nandika, Qin, Vicky Mengqi, Liew, Huiling, Sidhu, Harvinder Raj Singh, Ng, Jun Jie, Subramaniam, Tavintharan, Tan, Elaine, Koh, Gerald Choon Huat, Best, James, Wong, Julian, Car, Josip, Ho, Andy Hau Yan, Venkataraman, Kavita

“…Additionally, more FC knowledge increased the likelihood by 20% (OR=1.21; 95% CI=1.10–1.33), and higher diabetes-related stress increased it by 1.03 times (OR=1.03; 95% CI=1.02–1.05). Conclusions: Our findings underscore the interplay of various factors influencing FC behaviours among individuals with diabetes and call for targeted interventions and tailored strategies to improve FC practices in this vulnerable population.…”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…METTL8, however, modified only mRNA, as determined by biochemical and genetic analyses in Mettl8 null-mutant mice and two human METTL8 mutant cell lines. Our findings provide the first evidence of the existence of m3C modification in mRNA, and the discovery of METTL8 as an mRNA m3C writer enzyme opens the door to future studies of other m3C epitranscriptomic reader and eraser functions.…”
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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration by Goh, Catherine Wenhui, Lee, Irene Chengjie, Sundaram, Jeyapriya Rajameenakshi, George, Simi Elizabeth, Yusoff, Permeen, Brush, Matthew Hayden, Sze, Newman Siu Kwan, Shenolikar, Shirish

“…Concomitant with TDP-43 aggregation and proteolysis after prolonged arsenite exposure, GADD34-bound CK1ϵ catalyzed TDP-43 phosphorylations at serines 409/410, which were diminished or absent in GADD34−/− cells. Our findings highlight that the phosphatase regulator, GADD34, also functions as a kinase scaffold in response to chronic oxidative stress and recruits CK1ϵ and oxidized TDP-43 to facilitate its phosphorylation, as seen in TDP-43 proteinopathies.…”
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The capabilities of Multiclass Support Vector Machine (MSVM) training algorithms in grading agarwood essential oil by Anis Hazirah ‘Izzati H., Al-Hadi, Siti Mariatul Hazwa, Mohd Huzir, Nurlaila, Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The agarwood essential was graded into five grades (low, medium low, upper low, medium high, and high) and six grades (low, medium low, upper low, medium high, high, and upper high). The findings of this paper show the confusion matrix for five grades and six grades have no mismatch between actual and predicted data. …”
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Experimental and Computational Advancements in Peptidomimetic Ligand Discovery by Lee, Michael Alan

“…At the same time, discovery tools for finding peptides that modify PPIs have evolved, including advances in affinity selection techniques and combinatorial chemistry. …”
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Revealing Structural and Spin-state Dependent Reactivity of Single Atom Catalysts (SACs) with Systematically Improvable Computational Tools by Jia, Haojun (贾皓钧)

“…The ML models demonstrate superior accuracy in predicting reaction energetics compared to traditional scaling relationships. The findings validate codoping as a powerful strategy for tuning the properties of SACs to achieve enhanced ORR performance. …”
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Towards Synergistic Understanding of Language Processing in Biological and Artificial Systems by Hosseini Asl, Eghbal

“…I show that brain responses to stimuli (sentences) that are represented similarly across multiple successful ANNs are easier to predict from model representations; in contrast, brain responses to sentences that are represented differently across models are challenging to predict, despite high consistency among human participants. Extending these findings to the domain of vision, I suggest that the principle of representation universality may underlie information processing across various domains. …”
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Shifting Paradigms: Data-Centric Approach for Marine Statics Correction using Symmetric Autoencoding by Kanniah, Brindha

“…This notable precision improvement using SymAE highlights how a streamlined data-centric paradigm outperforms the traditional model-centric paradigm of marine statics correction. This finding is pivotal as it is the foundation that lays the groundwork and opens the path towards the real-world deployment of SymAE for statics correction in challenging deepwater environments.…”
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Design, fabrication and characterization of organic-inorganic hybrid solar cells by Ahmed Ali Said Ahmed

“…Moreover, the literature review provides the information about different types of lead-free solar cells and their advantages and their drawbacks. The achieved findings in this thesis include the following: (1) Six NDI-based molecules have been designed and synthesized as electron transporting layers in inverted perovskite solar cells; (2) Two pyrene-based molecules were designed and synthesized as electron transporting layers; (3) The effect of sulfur position in pyrene-based molecules was investigated (4) Three N-type conjugated polymers were explored as electron transporting layer (5) The effect of embedded sp2-nitrogen in donor and acceptors of conjugated polymer was explored and (6) Tellurium tetraiodide was explored as a promising light absorber in solar cells. …”
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