An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study by Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J. M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., Hart, Leen M. 't, van de Wiel, Mark A., Beulens, Joline W. J.

“…Inclusion of molecular markers improves the prognostic performance beyond that of clinical variables by up to 5%. Such prognostic models could be useful for identifying people with diabetes at high risk of progressing quickly to treatment intensification. …”
Get full text

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John Campbell, Kooner, Jaspal S., Scott, William R.

Get full text

Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk by Zhu, Yinghan, Maikusa, Norihide, Radua, Joaquim, Sämann, Philipp G., Fusar-Poli, Paolo, Agartz, Ingrid, Andreassen, Ole A., Bachman, Peter, Baeza, Inmaculada, Chen, Xiaogang, Choi, Sunah, Corcoran, Cheryl M., Ebdrup, Bjørn H., Fortea, Adriana, Garani, Ranjini Rg, Glenthøj, Birte Yding, Glenthøj, Louise Birkedal, Haas, Shalaila S., Hamilton, Holly K., Hayes, Rebecca A., He, Ying, Heekeren, Karsten, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kristensen, Tina D., Kwon, Jun Soo, Lawrie, Stephen M., Lebedeva, Irina, Lee, Jimmy, Loewy, Rachel L., Mathalon, Daniel H., McGuire, Philip, Mizrahi, Romina, Mizuno, Masafumi, Møller, Paul, Nemoto, Takahiro, Nordholm, Dorte, Omelchenko, Maria A., Raghava, Jayachandra M., Røssberg, Jan I., Rössler, Wulf, Salisbury, Dean F., Sasabayashi, Daiki, Smigielski, Lukasz, Sugranyes, Gisela, Takahashi, Tsutomu, Tamnes, Christian K., Tang, Jinsong, Theodoridou, Anastasia, Tomyshev, Alexander S., Uhlhaas, Peter J., Værnes, Tor G., van Amelsvoort, Therese A. M. J., Waltz, James A., Westlye, Lars T., Zhou, Juan H., Thompson, Paul M., Hernaus, Dennis, Jalbrzikowski, Maria, Koike, Shinsuke

Get full text

The iHealth-T2D study, prevention of type 2 diabetes amongst South Asians with central obesity and prediabetes: study protocol for a randomised controlled trial by Kasturiratne, Anuradhani, Khawaja, Khadija I., Ahmad, Sajjad, Siddiqui, Samreen, Shahzad, Khurram, Athauda, Lathika K., Jayawardena, Ranil, Mahmood, Sara, Muilwijk, Mirthe, Batool, Tayyaba, Burney, Saira, Glover, Matthew, Palaniswamy, Saranya, Bamunuarachchi, Vodathi, Panda, Manju, Madawanarachchi, Suren, Rai, Baldeesh, Sattar, Iqra, Silva, Wnurinham, Waghdhare, Swati, Jarvelin, Marjo-Riitta, Rannan-Eliya, Ravindra P., Gage, Heather M., van Valkengoed, Irene G. M., Valabhji, Jonathan, Frost, Gary S., Loh, Marie, Wickremasinghe, Ananda R., Kooner, Jaspal S., Katulanda, Prasad, Jha, Sujeet, Chambers, John C.

“…Endpoints: The primary endpoint is new-onset T2D at 3 years, defined as (i) HbA1c ≥ 6.5% or (ii) physician diagnosis and on treatment for T2D. …”
Get full text

The evolution and fate of waste plastics in landfills subject to physical and biochemical processes — implications for microplastics by Lu, Xuhong

“…In this study, identical compositions of municipal solid waste (MSW) were loaded into five laboratory-scale bioreactors, with three of them supplemented with 5.0 mg of polypropylene (PP) MPs per kg of dry MSW. …”
Get full text

AI techniques in CFD: leveraging physical priors with deep learning to improve on numerical solvers by Loh, Jessica Sher En

“…Also, experimental results on two datasets with five different state-of-the-art GNN methods for CFD indicate that the SV, DID, FVF and low resolution-based residual training can effectively reduce the predictive error of current GNN-based methods by as much as 41%. …”
Get full text

Studies on the assessment of abdominal aortic aneurysm rupture risk by Canchi, Tejas

“…The resulting six geometric indices can be used as geometric surrogates to quantify wall stresses in the patients. The five indices in addition to maximum diameter can predict the spatially averaged wall stresses with an accuracy of 72.87% in the Asian patient group and 74.74% in the Caucasian patient group. …”
Get full text

#Hooked? Extending the social cognitive model in examining the antecedents of problematic social network sites use among Singaporean adolescents and adults by Lee, Edmund Wei Jian

“…The overall analysis showed that the social cognitive model was a viable communication model in understanding problematic SNSs use as it had good psychometric properties and all the hypothesized paths were significant. Chapter Five—which is the third study—builds upon the findings of Chapter Four by postulating that problematic SNSs use is a three-dimensional factor comprising of excessive SNSs use, withdrawal symptoms, and negative outcomes, and extends the social cognitive model to include both external- (relationship with parents) and individual-level antecedents (i.e., depression, loneliness, dependence on SNSs for identity formation, and self-reactive outcome expectations). …”
Get full text

Improved 3-D frequency-selective structures and their applications by Ahmed Abdelmottaleb Abdelfattah Attia Omar

“…A 67% and 79% thickness reduction compared to the basic bandpass 3-D frequency-selective structure is achieved by employing three- and five-layer folded substrate, respectively. Moreover, a half-cylindrically shaped radome as an example of a conformal frequency-selective surface is constructed based on the proposed technique and integrated with a broadband horn antenna. …”
Get full text
Get full text

Prioritising conservation areas in Southeast Asia: highlighting zoological biodiversity hotspots and assessing spatiotemporal patterns of the felids guild by Chiaverini, L

“…Biodiversity is declining globally, at rates comparable with the five previous mass extinctions of Earth’s history. …”

Amino-functionalised β-diketiminate ligands (N-nacnacs): Synthesis and coordination chemistry with Main Group elements by Huan, D

“…On the other hand, metathesis reactions of (<b>1-Dipp</b>)SiCl with sources of H- or tBuO- are found to result in a ring contraction process, generating five-membered aza-butadienyl SiIV-complexes of the form (<b>5-Dipp</b>)Si(NDipp)R (R = H, ^tBuO). …”

Genetic and observational associations of nuclear magnetic resonance-measured lipid-related traits and atherosclerotic cardiovascular mortality in the Mexico City Prospective Study by Wang, Y

“…NMR lipid traits were also associated with a range of baseline sociodemographic and lifestyle characteristics. GWAS of five major lipid traits revealed hundreds of conditionally independent signals, including multiple previously known genetic loci involved in lipid metabolism (e.g., variants in <em>APOE, CELSR2, PCSK9, APOB, HMGCR, LPA, LPL, LDLR</em> for LDL-C) plus several potentially novel ones. …”

Molecular and immunological profiling of Bartonella spp. in shelter cat population in Peninsular Malaysia by Alias, Nurul Najwa Ainaa

“…Surveys from management practices of shelter cats revealed that five out of ten shelters were practicing ectoparasite control and 93.3% (28/30) shelter’s personnel were aware that cat and cat flea might contribute to zoonotic diseases. …”
Get full text

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Palafox, Marta, Monserrat, Laia, Bellet, Meritxell, Villacampa, Guillermo, Gonzalez-Perez, Abel, Oliveira, Mafalda, Brasó-Maristany, Fara, Ibrahimi, Nusaibah, Kannan, Srinivasaraghavan, Mina, Leonardo, Herrera-Abreu, Maria Teresa, Òdena, Andreu, Sánchez-Guixé, Mònica, Capelán, Marta, Azaro, Analía, Bruna, Alejandra, Rodríguez, Olga, Guzmán, Marta, Grueso, Judit, Viaplana, Cristina, Hernández, Javier, Su, Faye, Lin, Kui, Clarke, Robert B., Caldas, Carlos, Arribas, Joaquín, Michiels, Stefan, García-Sanz, Alicia, Turner, Nicholas C., Prat, Aleix, Nuciforo, Paolo, Dienstmann, Rodrigo, Verma, Chandra Shekhar, Lopez-Bigas, Nuria, Scaltriti, Maurizio, Arnedos, Monica, Saura, Cristina, Serra, Violeta

Get full text

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Glob... by Naghavi, M, Ong, KL, Aali, A, Almidani, O, Bandyopadhyay, S, Basnyat, B, Maude, R, Dolecek, C, Lacey, BWH

“…As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. …”

Understanding the role of Enterococcus faecalis in polymicrobial wounds by Davient, Bala

“…Since E. faecalis T7SS encodes toxins involved in bacterial competition, but not the MPT and EET systems, I hypothesized that a link between the energy metabolism systems and the T7SS may exist. …”
Get full text

The effects of atmosphere-ocean-wave coupling during tropical cyclone by Garg, Nikhil

“…This transfer of momentum (from atmosphere to ocean) is not a one-way link, i.e., there are feedback effects from ocean (both in terms of enthalpy and momentum) on the atmospheric boundary layer. …”
Get full text

Towards A Robust Integrated Urban Mobility System: Public Transit and Ride-Sharing Systems by Guo, Xiaotong

“…The dissertation presents five distinct studies to elaborate on these objectives. …”
Get full text
Get full text

Enhancing tensile and fatigue properties of additively manufactured alloys by post-processing heat treatment by Radhakrishnan, Jayaraj

“…Additionally, to gain clarity about wide spectrum of mechanical properties of LB-PBF Inconel 718 reported in literature, tensile properties of as-built specimens fabricated using two different LB-PBF machines were considered. Amongst the five different heat treatment schedules examined, one set led to the retention of as-built grain morphology and texture with the formation of the δ phase. …”
Get full text

Semantic scene understanding on 3D point clouds by Dong, Shichao

“…This is a fundamental and challenging task for scene understanding, with a variety of real-world applications, such as indoor robots, autonomous driving, drones, AR/VR devices, etc. We propose five different novel methods, including one fully supervised method, two weakly supervised methods, one zero-shot method, and an augmentation method to enhance model generalization. …”
Get full text