Finding transcription factor binding motifs for coregulated genes by combining sequence overrepresentation with cross-species conservation by Jia, Hui., Li, Jinming.

“…However, the current prevailing methods yield a large number of false positive predictions due to the short, variable nature of transcriptional factor binding sites (TFBSs). We proposed here a method that combines sequence overrepresentation and cross-species sequence conservation to detect TFBSs in upstream regions of a given set of coregulated genes. …”
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A Coxsackievirus B1-mediated nonlytic extracellular vesicle-to-cell mechanism of virus transmission and its possible control through modulation of EV release by Jorfi, Samireh, Ansa-Addo, Ephraim A., Mariniello, Katia, Warde, Purva, Bin Senian, Ahmad Asyraf, Stratton, Dan, Bax, Bridget E., Levene, Michelle, Lange, Sigrun, Inal, Jameel

“…This was confirmed by detecting CVB1 virions inside HeLa cells after co-culture with CVB1-mEVs; EV release may also prevent apoptosis of infected cells whilst spreading apoptosis to secondary sites of infection.…”
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Does bankruptcy law prevent internalization of environmental costs: evidence from China by Li, Xingwei

“…On analyzing these cases, public funds are found to have paid for environmental costs of bankrupt polluters, contaminated sites are often left unremedied following bankruptcy, and in some cases, bankruptcy law has become a tool for some companies to escape their environmental responsibilities. …”
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Bacterial phylogenetic reconstruction from whole genomes is robust to recombination but demographic inference is not by Hedge, J, Wilson, DJ

“…Surprisingly, removing recombining sites can exacerbate branch length distortion caused by recombination.Phylogenetic tree reconstruction is a popular approach for understanding the relatedness of bacteria in a population from differences in their genome sequences. …”

Making art, making value online: NFTs, Blockchains and online art economies by Cooke, H

“…The paper argues that NFTs possess an affective force among these groups, allowing them to endure as enchanted digital sites of future promises despite constant threats of deception, volatile markets, and scams.…”

Evaluating urban microclimate temperature using Envi-Met Simulation Model: a case study conducted in two city areas, Pudu and Wangsa Maju by Anis Batrisyia Asmadi, Alamah Misni, Mohamed Brahimi

“…A similar scale was used to simulate these sites with the same climatic conditions. Urban layout, building heights and densities, human movement, landcover, greening, and pavements were discovered to impact temperature change significantly. …”
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Ruthenium(ii) Polypyridyl complexes as FRET donors: structure- and sequence-selective DNA binding and anti-cancer properties by E. Elgar, Christopher, Yusoh, Nur Aininie, R. Tiley, Paul, Kolozsvári, Natália, G. Bennett, Laura, Gamble, Amelia, V. Péan, Emmanuel, L. Davies, Matthew, J. Staples, Christopher, Ahmad, Haslina, R. Gill, Martin

“…Binding affinities toward duplex, G-quadruplex, three-way junction, and mismatch DNA were determined, and derived FRET donor–acceptor proximities provide information on potential binding sites. Molecules characterized by this method demonstrate encouraging anticancer properties, including synergy with the PARP inhibitor Olaparib, and mechanistic studies indicate that [Ru(PIP)2(5,5′dmb)]2+ acts to block DNA replication fork progression.…”

Human health risk, potentials of biomonitoring and phytoremediation of copper using Amaranthus viridis by Al-Mutairi, K.A., Yap, C.K.

“…This study aimed to determine copper (Cu) levels in Amaranthus viridis collected from 11 Peninsular Malaysia sampling sites and to estimate its human health risk. In addition, it also aims to assess the potential of A. viridis as a biomonitor and phytoremediator of Cu pollution. …”
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Wind characteristics of Oman by Sulaiman, M.Yusof, Akaak, Ahmed Mohammed, Abd Wahab, Mahdi, Zakaria, Azmi

“…Wind data from four stations inOman are analyzed. The sites are located at latitudes from 17°N to 23°N and longitudes from 54°E to 59°E with nearly equal elevation (18 m) from sea level. …”
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Self-Nanoemulsifying Drug Delivery System (SNEDDS) formulation and molecular docking of mahogany seed extract (Swietenia mahagoni) as anti-hyperglycemic by Mushawwir Taiyeb, Mushawwir Taiyeb, Hartati Hartati, Hartati Hartati, Arwansyah Arwansyah, Arwansyah Arwansyah, Dahlia, Dahlia, Abd. Muis, Abd. Muis, A. Mu'nisa, A. Mu'nisa, Arif, Abdur Rahman, Md. Salleh, Liza

“…The outcome suggested that these substances are bonded to the alpha-glucosidase catalytic sites by hydrogen bonding and hydrophobic interactions and are stable during MD simulation, suggesting that the primary components of mahogany seed may become potential alpha-glucosidase inhibitors to treat diabetes.…”
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Generation of lentiviral-mediated shRNA vectors to inhibit the expression of caspase-1 and Pycard/ASC in dendritic cells. by Tan, Bee Kim.

“…Collectively, we have generated an efficient lentiviral vector-mediated shRNA silencing system in primary cell lines which could provide an insight to into the biological mechanisms involved in inflammasome activation.…”
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Analysis of hepatocyte antigen presentation and T cell/hepatocyte interaction in the context of hepatitis B virus Infection. by Noviani, Maria.

“…Nevertheless, as this study was performed with hepatocyte lines, further ex vivo study is needed to validate our current findings. …”
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Discovery of exosomes as gastric cancer biomarkers from conditioned cell culture media. by Low, Su Jun.

“…We isolated exosomes by concentrating 100ml of conditioned cell culture media from 3 gastric cancer cell lines AGS, NCIN87 and IM95, and subjected them to ultracentrifugation. …”
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A study on factors affecting receptivity to traditional chinese medicine In Singapore. by Chu, Hui Wen., Liu, Jia., Tan, Pei Ting.

“…Differences in opinions were also observed along socio-economic lines such as age, education, ethnicity, dominant language and gender. …”
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Effects of hemodynamic shear stress on circulating breast cancer cells by Khairunisa Liyana Abdul Malek

“…In this project, three lines of metastatic breast cancer cells, 231-C3, 231-M1 and 231-M1A were circulated in a microfluidic model mimicking the blood circulatory system over four different time periods: 2 hours, 4 hours, 9 hours and 18 hours while being exposed to three different hemodynamic shear stress at values of 15 dyn/cm2, 30 dyn/cm2 and 45 dyn/cm2. …”
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Laplacian Regularized Subspace Learning for interactive image re-ranking by Zhang, Lining., Wang, Lipo., Lin, Weisi.

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Motive and malice prepensed by Getzler, J

“…I would open the notes arriving from Magdalen with great anticipation, looking forward to discussing the contents with David, and knowing that his lines would set me off into fresh discoveries in libraries and archives for a good few weeks or months. …”

Statistical theory of the broadband two-plasmon decay instability by Rusko, RT, Bingham, R, Silva, LO, Harper, M, Aboushelbaya, R, Myatt, JF, Norreys, PA

“…The instability-quenching properties of a spectrum of discrete lines spread over some bandwidth have also been studied. …”

Selective targeting of MYC mRNA by stabilized antisense oligonucleotides by Gill, Taylor, Wang, Haichuan, Bandaru, Raj, Lawlor, Matthew, Lu, Chenyue, Nieman, Linda T, Tao, Junyan, Zhang, Yixian, Anderson, Daniel G, Ting, David T, Chen, Xin, Bradner, James E, Ott, Christopher J

“…MYCASO treatment of cancer cell lines leads to significant inhibition of cellular proliferation while specifically perturbing MYC-driven gene expression signatures. …”
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Unsupervised Learning for Generative Scene Editing and Motion by Fang, David S.

“…In this thesis, we propose two distinct lines of unsupervised learning work with generative applications: 1) BlobGSN and 2) optical flow estimation and flow generation with diffusion models. …”
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