Molecular dynamics study on the mechanism of high-fidelity CRISPR-Cas9 system by Liu, Zhehui

“…Our simulation results suggested that HF-SpCas9 would have a more rigid recognition lobe and a more opened conformation between the catalytically active site and the target scissile phosphates. And the mutant systems also have demonstrated a weaker binding energy between Cas9 protein and gRNA:dsDNA complex. …”
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Reliability assessment of restructured power systems using reliability network equivalent and pseudo-sequential simulation techniques by Ding, Yi, Wang, Peng, Goel, Lalit, Billinton, Roy, Karki, Rajesh

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Night flight facilitates late breeding catch-up in a long-distance migratory seabird by Siddiqi-Davies, K, Wynn, J, Padget, O, Bond, S, Danielsen, J, Fayet, AL, Fisher-Reeves, L, Freeman, R, Gillies, N, Kirk, H, Maurice, L, Morgan, G, Syposz, M, Shoji, A, Guilford, T

“…Long-distance migrants must optimise their timing of breeding to capitalise on resources at both breeding and over-wintering sites. In species with protracted breeding seasons, departing earlier on migration might be advantageous, but is constrained by the ongoing breeding attempt. …”

Structural dynamics of the ubiquitin specific protease UPS30 in complex with a cyanopyrrolidine-containing covalent inhibitor by O’Brien, DP, Jones, HBL, Shi, Y, Guenther, F, Vendrell, I, Viner, R, Brennan, PE, Mead, E, Zarganes-Tzitzikas, T, Davis, JB, Pinto-Fernández, A, England, KS, Murphy, EJ, Turnbull, AP, Kessler, BM

“…A comparison to a non-covalent USP30 inhibitor containing a benzosulfonamide scaffold revealed a slightly different binding mode closer to the active site Cys77, which may provide the molecular basis for improved selectivity towards USP30 against other members of the DUB enzyme family. …”

Prehistoric foragers and farmers in South-east Asia: Renewed investigations at Niah Cave, Sarawak by Barker, G, Barton, H, Beavitt, P, Bird, M, Daly, P, Doherty, C, Gilbertson, D, Hunt, C, Krigbaum, J, Lewis, H, Manser, J, McClaren, S, Paz, V, Piper, P, Pyatt, B, Rabett, R, Reynolds, T, Rose, J, Rushworth, G, Stephens, M

“…The critical importance of the Niah stratigraphies was commonly identified – including by Tom Harrisson himself – as because the site provided a continuous sequence of occupation over the past 40,000 years. …”

Predicting airway immune responses and protection from immune parameters in blood following immunization in a pig influenza model by Gubbins, S, Paudyal, B, Dema, B, Vats, A, Ulaszewska, M, Vatzia, E, Tchilian, E, Gilbert, SC

“…Although mucosally administered vaccines have the potential to induce more protective immune response at the site of viral infection, quantitating such immune responses in large scale clinical trials and developing correlates of protection is challenging. …”

A clinical perspective on muscle specific kinase antibody positive myasthenia gravis by Keritam, O, Vincent, A, Zimprich, F, Cetin, H

“…MuSK-IgG4 are monovalent and block the binding site for LRP4 on MuSK, thereby inhibiting the downstream phosphorylation pathway and compromising the formation of AChR clusters. …”

Three year performance of international provenance trials of Acacia auriculiformis by Awang, Kamis, Venkateswarlu, Perugupalli, Abd.Shukor, Nor Aini, Adjers, Goran, Bhumibhamon, Suree, Kietvuttinon, Bopit, Pan, Fuh-Juinn, Pitpreecha, Kiatkong, Simsiri, Apisit

“…The performance of 25 provenances in international trials on seven sites in four countries was assessed for survival and growth at 3 years. …”
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Preliminary survey on critical cost overrun factors in the construction industry of Pakistan by Ahmed Abbasi, Suhail, Abas, Nor Haslinda, Sohu, Samiullah

“…Based on mean scores critical cost overrun factors are schedule delay, financial difficulties faced by contractor, fluctuation in price of materials, poor site management, poor contract management, inadequate planning, fraudulent practices and kickbacks, frequent design changes, change in scope of project. …”
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Validating the Safety Culture Model in Manufacturing Small and Medium Enterprises (SMEs) in Malaysia (S/O: 12365) by Hassan, Zuraida, Mohd Zin, Md. Lazim, Subramaniam, Chandrakantan, Mohd Shamsudin, Faridahwati, Sri Ramalu, Subramaniam

“…The nature of most accidents at factories shows that the manufacturing industry is a hazardous site to workers’ safety and health. Factors involved include human behaviour, the difficulties of works, unsafe safety culture, dangerous machinery and equipment being used, and non-compliance to the various set procedures. …”
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New insights into transparent exopolymer particles (TEP) formation from precursor materials at various Na+/Ca2+ ratios by Meng, Shujuan, Liu, Yu

“…We found that the formation of TEP from precursor materials studied was essentially determined by the Ca2+ concentration at a fixed sodium concentration, while Na+ at high Na+/Ca2+ ratio out-competed Ca2+ for the binding sites on the precursor molecules, leading to a significantly decreased trend of TEP formation. …”
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Preventing interreligious conflict : lessons from the ambivalence of the sacred and Singapore by Ho, Chee Feng

“…Viewed from the lens of Samuel Huntington and Philip Jenkins, religion appears destined to be a major fault line causing instability in a clash of civilizations. …”
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Structure and dynamics of magnetic domain walls in multi-sublattice magnetic oxides by Huang, Siying

“…We investigated the DW depinning dynamics in Pt/BiYIG thin film, presenting a phase diagram of this pinning event, which proves the crucial role of minimizing the pinning effect in achieving fast DW velocity. …”
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DevOps for Databases : A practical guide to applying DevOps best practices to data-persistent technologies / by Jambor, David, author 656261

“…Database administrators are no longer the only experts; site reliability engineers (SREs) and DevOps engineers are database experts as well. …”
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Mapping refuse profile in Singapore old dumping ground through electrical resistivity, S-wave velocity and geotechnical monitoring by Yin, Ke, Tong, Huan Huan, Noh, Omar, Wang, Jing-Yuan, Giannis, Apostolos

“…Data were analyzed using an orthogonal set of plots by spreading 24 lines in two perpendicular geophone-orientation directions. …”
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Product optimization of a fed-batch fermentation process by Arshad, Ahmad, Noor Asma Fazli, Abdul Samad, Mohd Kamaruddin, Abd Hamid

“…Good agreement is obtained when the results are validated against published work. To provide on-line estimates of the difficult to measure penicillin concentration, Partial Least Squares model is employed. …”
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Solvability Regions of Affinely Parameterized Quadratic Equations by Dvijotham, Krishnamurthy, Nguyen, Hung, Turitsyn, Konstantin

“…The quadratic systems in infrastructure networks are parameterized- the parameters can represent uncertainty (estimation error in resistance/inductance of a power transmission line, for example)or controllable decision variables (power outputs of generators,for example). …”
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Lifting Directional Fields to Minimal Sections by Palmer, David, Chern, Albert, Solomon, Justin

“…Directional fields, including unit vector, line, and cross fields, are essential tools in the geometry processing toolkit. …”
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Enhancing Roll Form Bending Processes through Experimentation and Informed Predictive Analysis: A Strategic Approach to Optimize Tooling by Kompella, Sarvagnya

“…These insights can be integrated within Novelis’ production line to boost production efficiency and roll performance. …”
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Affordable Fiber Extrusion Device for Educational Purposes: Design Improvements, Controls Development, and Manufacturing Scale-up by Zhang, Yiqian

“…Building on the 2023 team’s progress, the 2024 project objectives include refining the design, developing controls, scaling up manufacturing, designing the assembly line, managing inventory, creating educational content, and conducting user testing and pilot runs. …”
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