Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…Despite global improvements in metabolic health after weight loss, diurnal differences persist, suggesting that night-time metabolic dysfunction may represent a unique risk factor for MASLD. These findings will help establish the optimal window for energy intake in patients with MASLD, and help guide the best time-of-day to deliver medications currently in development.…”

Molecular characterisation of methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius in cats, dogs and pet owners in a Veterinary Hospital by Afshar, Mohammad Farzad

“…In brief, both MRSA and MRSP that were detected in the current study were multidrug resistant and molecularly related to other Southeast Asian countries. The findings from this study have brought new insights into the current status of antimicrobial resistance and molecular characteristics of both S. aureus and S. …”
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Effectiveness of King’s theory of goal attainment in blood glucose management for newly diagnosed patients with type 2 diabetes: randomized controlled trial by Yan, Man, Yu, Yingchun, Li, Shuping, Zhang, Peiling, Yu, Jiaxiang

“…Conversely, the control group maintained relatively higher values for these metrics at the same time point (P<.05). These findings underscore the efficacy of online feedback in managing glycemic control and reducing psychological distress associated with hypoglycemia. …”
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Prevalence and risk factors of long covid and its associated adverse work outcomes among workers in the manufacturing sector in Malaysia – a mixed-methods study protocol by Mohd Yusoff, Hanizah, Che Mohamed, Norfariha, Yew, Sheng Qian, Mohammed Nawi, Azmawati, Rashidah Ismail, Ohnmar Htwe, Mohd Tohit, Noorlaili, Mohamed, Zuraida, Muhamad Noordin, Muhamad Ariff, Mohd, Fazlin Hazirah, Shariff, Mohammad Izzat Akmal, Shaharum, Muaz Haqim, Abd. Rahman, Anita, Dapari, Rahmat

“…The aim of the FGDs is to explore the understanding, experience, and potential risk factors of Long Covid-19 among manufacturing workers. Findings from the FGDs will be analysed thematically. …”
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Factors influencing career success of women managers in Malaysian public sector by Abdul Manaf, Saidatul Hizam

“…Three groups of variables were identified in predicting women managers’ objective and subjective career success; i) individual related variables (self-efficacy, proactive personality and extraversion), ii) human capital variables (work experience and sense of competence) and iii) organizational related variables (organizational culture and perceived organizational justice). The findings of this study revealed that individual, human capital and organizational factors have significant effect on women managers’ objective and subjective career success. …”
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Qualitative and quantitative accuracy evaluation of 18f-fdg PET/CT with TOF and NON-TOF system on beta value in BPL reconstruction by Hui, Ng Suk

“…Conclusion: Our study findings suggested that a beta value of 450 was optimal for TOF acquisition, while a beta value of 300 was recommended for non-TOF acquisition. …”
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In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Mechanistically, anti-proliferative and apoptotic effect of TA and its combination with cisplatin on U2OS cells were suggested to be modulated via JNK1 inhibition, ERK2 activation, and intrinsic apoptotic pathways. The findings suggest the potential inclusion of TA in cisplatin-based chemotherapy for osteosarcoma and warrant further investigation…”
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Laboratory studies on the mechanical properties of sulphur-based construction material at simulated Martian temperatures by Muhammad Nazrif, Muhammad Nazrif, Md. Noor, Norhazilan, Umar, Sarehati, Ahmad Shah, Mohamad Shazwan, Yahaya, Nordin, Kim, Jang-Ho Jay, Ng, Chiew Teng

“…The 60 % sulphur content is suggested for structural elements built internally whereas the 50 % sulphur content demonstrated a high potential in adapting to the harsh Martian environmental conditions. The findings of this study hoped to act as the initial outlook on how such Martian sulphur-based construction material would react upon fabrication on Mars.…”

Factors Influencing Students Intention to Choose Career of Halal Food Industry in Malaysia using Theory of Planned Behavior by Abu Bakar, Nashirah, Rosbi, Sofian, Haji Hashim, Hydzulkifli, Che Arshad, Noraziah

“…Conclusion: This study supported the hypothesis that indicates there is a positive and significant relationship of Attitude (A), Subjective Norm (SN) and Perceived Behavioral Control (PBC) towards Intention (I). The findings of this study add value to theoretical knowledge of career selection among university students. …”
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The Effectiveness of Flipped Classroom Strategy on Self-Directed Learning Among Undergraduate Mathematics Students by Mohd Nasir, Mohd Azrin, Alaudin, Ros Idayuwati, Ismail, Suzilah, Mat Ali, Nor A’tikah, Mohd Faudzi, Farah Nadia, Yusuff, Noraini, Mohd Pozi, Muhammad Syafiq

“…Overall, the students found that the flipped classroom strategy is potentially enhancing student’s engagement and performance in mathematics education. The findings have implications for the instructors to implement the flipped classroom strategy for mathematics subjects to acquire better performance among undergraduate students. …”
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Combating Household Bankruptcy: Developing a New Integrated Financial Education Model for Malaysian (S/O 13585) by Sawandi, Norfaiezah, Abu Bakar, Abu Sufian, Shaari, Hasnah, Amran, Noor Afza, Saad, Ram Al Jaffri

“…These expected positive consequences are in line with the 2011-2020 Financial Sector Plan (Area 8-Empowering Consumers) and the Securities Commission Inventor Education Blue Print. The key findings of the study, first, evidence suggests that the level of financial knowledge/literacy amongst Malaysian is arguably low as less than 50% respondents received high score. …”
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Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians : 6-year longitudinal study by Chua, Jacqueline, Chee, Miao Li, Chin, Calvin Woon Loong, Tham, Yih Chung, Tan, Nicholas, Lim, Sing Hui, Aung, Tin, Cheng, Ching-Yu, Wong, Tien Yin, Schmetterer, Leopold

“…Given that high IOP is a risk factor for glaucoma, our finding highlights the importance of controlling hypertension in older adults, where hypertension and glaucoma incidences are on a rise.…”
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Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

“…However, there was no significant difference in RGC density between Cav-1 KO and wild type mice. These findings highlight the role of Cav-1 in regulating neurovascular coupling and IOP and suggest that the loss of Cav-1 may predispose to vascular dysfunction and decreased RGC signaling in the absence of structural loss. …”
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Perceived inequality in society may not motivate increased food intake in the absence of personal socioeconomic disadvantage by Cheon, Bobby K., Low, Xenia, Wijaya, Darren Jeffian, Lee, Albert

“…Conclusions: Taken together with prior research on the effects of subjective socioeconomic disadvantage on increased energy intake, these findings suggest that perceptions of inequality in one’s society may be insufficient to stimulate heightened energy intake in the absence of personal socioeconomic disadvantage or inadequacy.…”
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Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling by Vinaiphat, Arada, Pazhanchamy, Kalailingam, JebaMercy, Gnanasekaran, Ngan, SoFong Cam, Leow, Melvin Khee-Shing, Ho, Hee Hwa, Gao, Yong-Gui, Lim, Kah-Leong, Richards, A. Mark, de Kleijn, Dominique P. V., Chen, Christopher P., Kalaria, Raj N., Liu, Jian, O'Leary, Deborah D., McCarthy, Neil E., Sze, Siu Kwan

“…Consequently, HS-induced hypertensive mice also displayed reduced vascular integrity of multiple organs including lungs, kidneys, and heart. Conclusions: These findings provide novel molecular insight into HS-induced structural changes in eGC and EC composition that may increase cardiovascular risk and potentially guide the development of new diagnostics and therapeutic interventions.…”
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The identification of significant features towards travel mode choice and its prediction via optimised random forest classifier : An evaluation for active commuting behavior by Nur Fahriza, Mohd Ali, Ahmad Farhan, Mohd Sadullah, P.P. Abdul Majeed, Anwar, Mohd Azraai, Mohd Razman, Musa, Rabiu Muazu

“…Conclusions: The study has illustrated the efficacy of the optimised RF in predicting travel mode choice as well as identified the significant factors for the selection. The findings of the present study provide significant insight for policymakers to improve the performance of the public transportation system so that the users will benefit in terms of health and well-being from active commuting.…”
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Increased consumption of unsaturated fatty acids improves body composition in a hypercholesterolemic Chinese population by Haldar, Sumanto, Ponnalagu, Shalini, Osman, Farhana, Tay, Shia Lyn, Wong, Long Hui, Jiang, Yuan Rong, Leow, Melvin Khee-Shing, Henry, Christiani Jeyakumar

“…Long-term studies are needed to confirm findings. This study had been registered on clinicaltrials.gov (Identifier No.: NCT03964857, https://www.clinicaltrials.gov/ct2/show/NCT03964857).…”
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A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer by Ho, Cowan, Zhao, Zitong, Chen, Xiu Fen, Sauer, Jan, Saraf, Sahil Ajit, Jialdasani, Rajasa, Taghipour, Kaveh, Sathe, Aneesh, Khor, Li-Yan, Lim, Kiat-Hon, Leow, Wei-Qiang

“…We further trained the composite AI-model's performance on a larger cohort of 105 resections WSIs and then validated our findings on a cohort of 150 biopsies WSIs against the classifications of two independently blinded pathologists. …”
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Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…Investigations using patient-derived lymphoblastoid cell line carrying heterozygous RAD51C L134S variant showed an impairment in RAD51 chromatin association and replication fork protection, suggestive of deleteriousness of this VUS variant. Overall, our findings provide more insights into molecular roles of RAD51C in replication fork integrity maintenance and in DSB repair.…”
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Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…By contrast, a Monte Carlo simulation finds that on average, only 2.8 out of 21 (13%) of randomly assigned anomalies occur between 7 and 14days after an electron flux greater than 1.5 standard deviations above the mean. …”
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