Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c + Myeloid Dendritic Cell Maturation Arrest,... by Yeo, Tsin Wen, Woodberry, Tonia, Loughland, Jessica R., Minigo, Gabriela, Burel, Julie G., Amante, Fiona H., Piera, Kim A., McNeil, Yvette, Good, Michael F., Doolan, Denise L., Engwerda, Christian R., McCarthy, James S., Anstey, Nicholas M.

“…Induction of the kynurenine pathway and increased Treg activation, together with skewed mDC maturation, suggest P. vivax promotes an immunosuppressive environment, likely impairing the development of a protective host immune response.…”
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POWER TO CHOOSE / by Sargent, Haydn, author 656354

Selective lighting up of epiberberine alkaloid fluorescence by fluorophore-switching aptamer and stoichiometric targeting of human telomeric DNA G-quadruplex multimer by Zhang, Lihua, Liu, Hua, Shao, Yong, Lin, Clement, Jia, Huan, Chen, Gang, Yang, Danzhou, Wang, Ying

“…The steady-state absorption, steady-state/time-resolved fluorescence, and NMR studies demonstrate that EPI most likely interact with the 5′ end flanking sequence substructure beyond the core [Q] and the G-quadruplex tetrad in a much more specific manner than the other alkaloids. …”
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Structural analysis of the novel influenza A (H7N9) viral Neuraminidase interactions with current approved neuraminidase inhibitors Oseltamivir, Zanamivir, and Peramivir in the pre... by Tran-To Su, Chinh, Ouyang, Xuchang, Zheng, Jie, Kwoh, Chee Keong

“…Results: Combination of molecular docking and Molecular Dynamics simulation reveal that zanamivir forms more favorable and stable complex than oseltamivir and peramivir when binding to the active site of the H7N9 neuraminidase. And it is likely that the novel influenza A (H7N9) virus adopts a higher probability to acquire resistance to peramivir than the other two inhibitors. …”
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Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology by Gould, E, Fraser, HS, Parker, TH, Nakagawa, S, Griffith, SC, Vesk, PA, Fidler, F, Hamilton, DG, Abbey-Lee, RN, Abbott, JK, Aguirre, LA, Alcaraz, C, Aloni, I, Altschul, D, Arekar, K, Atkins, JW, Atkinson, J, Baker, CM, Barrett, M, Bell, K, Bello, SK, Beltrán, I, Berauer, BJ, Bertram, MG, Wood, A

“…In other words, analyses with results that were far from the mean were no more or less likely to have dissimilar variable sets, use random effects in their models, or receive poor peer reviews than those analyses that found results that were close to the mean. …”

Fiona Patrick - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Patrick, F

“…Self-loathing may be a relevant NSB in overweight/obese populations. Considering the likely heterogeneity of overweight/obese populations is important in future work.…”

Forwards in time approaches to understanding genealogies in Λ-Fleming-Viot type models by Wiederhold, B

“…The patterns of isolation by distance reveal that ancestors are more likely to have originated from areas of high population density. …”

Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates by Lu, J

“…Pre-clinical studies also indicate that the observed non-skeletal effects of bisphosphonates are likely due to mechanisms beyond inhibition of osteoclasts. …”

Long Covid: a global health issue – a prospective, cohort study set in four continents by Pazukhina, E, Garcia-Gallo, E, Reyes, LF, Kildal, AB, Jassat, W, Dryden, M, Holter, JC, Chatterjee, A, Gomez, K, Søraas, A, Puntoni, M, Latronico, N, Bozza, FA, Edelstein, M, Gonçalves, BP, Kartsonaki, C, Kruglova, O, Gaião, S, Chow, YP, Doshi, Y, Duque Vallejo, SI, Ibáñez-Prada, ED, Fuentes, YV, Hastie, C, O'Hara, ME, Balan, V, Menkir, T, Merson, L, Kelly, S, Citarella, BW, Semple, MG, Scott, JT, Munblit, D, Sigfrid, L

“…Participants in HICs were more likely to report not feeling fully recovered (54.3% vs 18.0%, p<0.001; 56.8% vs 40.1%, p<0.001), fatigue (42.9% vs 27.9%, p<0.001; 41.6% vs 27.9%, p<0.001), new/persistent fever (19.6% vs 2.1%, p<0.001; 20.3% vs 2.0%, p<0.001) and have a higher prevalence of anxiety/depression and impact on usual activities compared with participants in LMICs at 2 to <6 and 6 to <12 months post-COVID-19 hospital discharge, respectively. …”

Consensus on current management of endometriosis by Johnson, NP, Hummelshoj, L, World Endometriosis Society Montpellier Consortium

“…A different group of international experts from those participating in this process would likely have yielded subtly different consensus statements. …”

Internet tool to support self-assessment and self-swabbing of sore throat: development and feasibility study by Lown, M, Smith, KA, Muller, I, Woods, C, Maund, E, Rogers, K, Becque, T, Hayward, G, Moore, M, Little, P, Glogowska, M, Hay, A, Stuart, B, Mantzourani, E, Wilcox, CR, Thompson, N, Francis, NA

“…A web-based tool that helps people assess their sore throat, through the use of clinical prediction rules, taking throat swabs or saliva samples, and taking throat photographs, has the potential to improve self-management and help identify those who are the most and least likely to benefit from antibiotics. <br><strong> Objective:<br></strong> We aimed to develop a web-based tool to help patients and parents or carers self-assess sore throat symptoms and take throat photographs, swabs, and saliva samples for diagnostic testing. …”

Childhood bullying and mental health: understanding risk, resilience, and the role of anti-bullying interventions by Guzman Holst, C

“…Children and young people in these latter groups are more likely to have elevated levels of mental health problems (Singham et al., 2017). …”

Circadian rhythm and misalignment in the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD): an experimental medicine approach by Marjot, T

“…I show that 3-night shifts are associated with profound hepatic insulin resistance, a pathological hallmark of MASLD. This is likely to be related to a combination of circadian misalignment, sleep deprivation, and elevated light exposure during sleep. …”

Synergy of compress strain and antioxidant of platinum-copper for enhanced the oxygen reduction performance by Zhang, Jun, Liang, Pingjuan, Xu, Xinlan, Wang, Rong, Liu, Shuyue, Wang, Chunyuan, Liu, Boyu, Luo, Laizheng, Jin, Meng, Liu, Huan, Yi, Huan, Lu, Shi-Yu

“…Herein, we report a worm-liked PtCu nanocrystals dispersed on nitrogen-doped carbon hollow microspheres (Pt0.38Cu0.62/N-HCS). …”
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Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…Our observations suggest that internal charging from either past elevated radiation belt fluxes or some conditions related to relativistic electron enhancements (either causally or accidentally) is most likely responsible for the SSPA anomalies. We next consider the timing of these anomalies with respect to the local time (LT) and season. …”
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System-level design of low-carbon structures by Fang, Demi L.

“…“What is more likely to be associated with a reduction in emissions: switching from concrete to timber, or shortening the spans throughout the building?” …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Further, they highlight multiple approaches for efficacy in SCID settings and optimal combinations for WT settings. This work is likely to aid in the development of clinical non-genotoxic HSCT conditioning approaches that could benefit millions of people world-wide.…”
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Inclusions in calcite phantom crystals suggest role of clay minerals in dolomite formation by Farsang, Stefan, Pekker, Péter, Lampronti, Giulio I., Molnár, Zsombor, Milovský, Rastislav, Pósfai, Mihály, Ozdín, Daniel, Raub, Timothy D., Redfern, Simon Anthony Turner

“…While the micrometer-sized phyllosilicate and hematite particles were likely transported from the terra rossa and attached to the surface of growing calcite, the presence of phyllosilicates that are only a few atomic layers thick and of euhedral hematite, goethite, and dolomite crystals suggests that these particles precipitated along with the phantom calcite in situ, from an aqueous solution carrying terra rossa-derived and limestone-derived solutes. …”
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Aircraft noise, overheating and poor air quality in London primary schools' classrooms by Montazami, Azadeh

“…Through objective and subjective surveys, classrooms' indoor temperatures, air quality and background noise levels were evaluated and it was learnt that those schools located in the vicinity of Heathrow Airport are more likely to experience overheating and poor air quality. …”
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Outcomes of shoulder replacement surgery in routine care by Craig, RS

“…Patients aged over 85 years were far more likely to experience a serious adverse event (1 in 5 men and 1 in 10 women). …”