Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies by Mohan Rajan Pradhan

“…Combining systematic data mining and quantification of these hydration sites using „JAL‟ a novel two water-bridge motif is identified that appears to be central to the nucleotide recognition by eIF4E. This is a novel finding and I believe will facilitate the design of specific inhibitors of eIF4E which is a therapeutic target in oncology. …”
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New algorithms for hardware-efficient implementation of sign detection and magnitude comparison in residue number systems by Sachin Kumar

“…Specifically, the following new findings and results are reported in this thesis. …”
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Cardiac-sympathetic dysfunction in hypertension by Bardsley, E

“…Chapter seven also discussed the implications of the findings described, with an emphasis on the potential future avenues of research within the field of neurogenic hypertension.…”

Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Feigin, VL, Abate, MD, Abate, YH, Bandyopadhyay, S, Bennett, DA, Lacey, B, Newton, CRJ

“…We also calculated burden of stroke attributable to 23 risk factors and six risk clusters (air pollution, tobacco smoking, behavioural, dietary, environmental, and metabolic risks) at the global and regional levels (21 GBD regions and Socio-demographic Index [SDI] quintiles), using the standard GBD methodology. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. <p><b>Findings</b></p> In 2021, stroke was the third most common GBD level 3 cause of death (7·3 million [95% UI 6·6–7·8] deaths; 10·7% [9·8–11·3] of all deaths) after ischaemic heart disease and COVID-19, and the fourth most common cause of DALYs (160·5 million [147·8–171·6] DALYs; 5·6% [5·0–6·1] of all DALYs). …”

Epidemiology of endometriosis in women of Arab ancestry by Mousa, M

“…</p> <p>Conclusion</p> <p>This study provided novel findings of the clinical presentation and risk factors of endometriosis among Arab women from a combined hospital and population-based sites. …”

A systematic review of obsessive-compulsive disorder symptomatology in religious people of Abrahamic faiths: implications for clinical practice by Hassan, H

“…A thematic analysis of free text across all participants found three main themes: ‘We are Too Different’, ‘It’s not Worth the Risk’, and ‘What we Need for Therapy to Work’. These findings suggest that mentioning religion as a value to be considered in therapy positively impacts upon how therapy is perceived by British Muslims.…”

Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…Pain was reported as a seizure trigger in three patients, an unusual finding in epilepsy.</p> <p>Cytokine concentrations measured by a multiplex bead-based immunoassay combined with flow cytometry showed GAD65 autoantibody-positive DRE patient plasmas were enriched for IL1b, IL4, IL10, IL15 and TNFa, consistent with multifaceted immune system involvement. …”

Effects of Edible bird's nest on quality of Arabian stallion semen and post-breeding induced endometritis in mares by Al-Khaldi, Khalid Obaid Salim

“…Glandular density and conception rate was also higher (P>0.05) in mares treated with H-EBN relative to LEBN and control. These findings depict the promising role of EBN in preserving chilled and frozen semen quality, and as an alternative reproductive medicine in selectively targeting mares susceptible to PBIE.…”
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Effect of consumers' awareness about country of origin on purchasing decision in Klang Valley, Malaysia by Taheri, Nasim

“…Multiple regression analysis was applied to determine the relationship between socio-demographic factors, extracted factors and consumers’ awareness toward COO. The findings on cross tabulation showed that consumer’s age, religion and education have significant relationship with their awareness toward COO, while there are no significant relationship between gender, race, employment and income of respondents and awareness of consumers towards COO. …”
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Structure and functions of a metallo-beta-lactamase- like hypothetical protein bleg1_2437 from alkali-tolerant soil bacterium Bacillus lehensis G1 by Tan, Soo Huei

“…Furthermore, with the addition of 100 μM of zinc sulfate, the kcat/Km values of Bleg1_2437 towards all tested β-lactam antibiotics were increased approximately 2 to 5 fold. The findings of this study reveal on the presence of the clinically important and dangerous antibiotics-degrading enzyme, MBL, within the pool of HPs which are generally regarded as proteins of unknown functions and of no particular importance.…”
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Retention and storage stability of vitamins A and C in extruded native and pregelatinized starches by Abdul Manan, Siti Farhiah

“…It can be concluded that in all the extruded starches, the stability during extrusion and upon storage was significantly higher for vitamin C than vitamin A. The findings provided information on the application of the fixed extrusion conditions for better retention of vitamin A or vitamin C in starches. …”
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Neuroprotective effect of tocotrienol-rich fraction and a-tocopherol of vitamin E against glutamate toxicity in neuronal cells and astrocytes by Selvaraju, Thilaga Rati

“…The flow cytometry morphological findings were validated by scanning electron microscopy analysis. …”
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Factors associated with body weight status and internet addiction among malaysian university students in Penang: mixed method study before and during covid-19 pandemic by Isaac, Nesamalar

“…They were also encouraged to share their perception of face-to-face personal interaction with family and friends, sports and other offline activities as compared to similar online activities. The findings of this study prove that there is a significant contribution of demographic and socio-economic factors to internet addiction among Malaysian university/college students in Penang. …”
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Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis... by Reitsma, M. B., Kendrick, P. J., Ababneh, E., Abbafati, C., Abbasi-Kangevari, M., Abdoli, A., Abedi, A., Abhilash, E. S., Abila, D. B., Aboyans, V., Abu-Rmeileh, N. M., Adebayo, O. M., Advani, S. M., Aghaali, M., Ahinkorah, B. O., Ahmad, S., Ahmadi, K., Ahmed, H., Aji, B., Akunna, C. J., Al-Aly, Z., Alanzi, T. M., Alhabib, K. F., Ali, L., Alif, S. M., Alipour, V., Aljunid, S. M., Alla, F., Allebeck, P., Alvis-Guzman, N., Amin T. T., Amini, S., Amu, H., Amul, G. G. H., Ancuceanu, R., Anderson, J. A., Ansari-Moghaddam, A., Antonio, C. A. T., Antony, B., Anvari, D., Arabloo, J., Arian, N. D., Arora, M., Asaad, M., Ausloos, M., Awan, A. T., Ayano, G., Aynalem, G. L., Azari, S., B, D.B., Badiye, A. D., Baig, A. A., Bakhshaei, M. H., Banach, M., Banik, P.C., Barker-Collo, S. L., Bärnighausen, T. W., Barqawi, H. J., Basu, S., Bayati, M., Bazargan-Hejazi, S., Behzadifar, M., Bekuma, T. T., Bennett, D. A., Bensenor, I. M., Berfield, K. S. S., Bhagavathula, A. S., Bhardwaj, N., Bhardwaj, P., Bhattacharyya, K., Bibi, S., Bijani, A., Bintoro, B. S., Biondi, A., Birara, S., Braithwaite, D., Brenner, H., Brunoni, A. R., Burkart, K., Butt, Z. A., Caetano dos Santos, F. L., Car, Josip, Cárdenas, R., Carreras, G., Carrero, J. J., Castaldelli-Maia, J. M., Cattaruzza, M. S. S., Chang, J. C., Chen, S., Chu, D. T., Chung, S. C., Cirillo, M., Costa, V. M., Couto, R. A. S., Dadras, O., Dai, X., Damasceno, A. A. M., Damiani, G., Dandona, L.

“…We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. …”
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Evaluating conversational agents for mental health: scoping review of outcomes and outcome measurement instruments by Jabir, Ahmad Ishqi, Martinengo, Laura, Lin, Xiaowen, Torous, John, Subramaniam, Mythily, Car, Lorainne Tudor

“…Descriptive and thematic analyses of the findings were performed. Results: We included 32 studies that targeted the promotion of mental well-being (17/32, 53%) and the treatment and monitoring of mental health symptoms (21/32, 66%). …”
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Doctor, Will You Pray for Me? : Medicine, Chaplains, and Healing the Whole Person / by Klitzman, Robert, author 655971

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Exciton Dynamics and Anisotropy in 2D Metal Organochalcogenolate Semiconductors by Lee, Woo Seok

“…This divergence in excitonic properties is attributed to the semi 1D Ag chains in AgSePh-F₂(2,3), in contrast to hexagonal 2D Ag network in AgSePh. This finding can be generalized to other blue-emitting 2D AgSePh-R compounds which exhibit either AgSePh-like or AgSePh-F₂(2,3)-like absorption spectra. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…Size fractionation of CM showed that the fraction of size smaller than 3 kDa in molecular weight retained the inhibitive of CM. The findings suggested that IB and CM have intrinsically different mechanisms of cancer inhibition. …”
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Individual-fMRI-approaches reveal cerebellum and visual communities to be functionally connected in obsessive compulsive disorder by Kashyap, Rajan, Eng, Goi Khia, Bhattacharjee, Sagarika, Gupta, Bhanu, Ho, Roger, Ho, Cyrus S. H., Zhang, Melvyn, Mahendran, Rathi, Sim, Kang, Chen, Annabel Shen-Hsing

“…While the main results were consistently observed with accounting for head motion and using another atlas, the key findings were not reproduced with GSR application. …”
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ESBL and AmpC β-lactamase encoding genes in E. coli from pig and pig farm workers in Vietnam and their association with mobile genetic elements by Hounmanou, Yaovi Mahuton Gildas, Bortolaia, Valeria, Dang, Son Thi Thanh, Truong, Duong, Olsen, John E., Dalsgaard, Anders

“…Overall, despite evidence of transferability of plasmids in the analyzed strains, our findings do not support that ESBL-producing E. coli from pigs or their ESBL/AmpC encoding plasmids are commonly spread to workers in close contact with the animals.…”
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