Crystal structure of the FK506 binding domain of plasmodium falciparum FKBP35 in complex with FK506 by Kotaka, Masayo, Ye, Hong, Alag, Reema, Hu, Guangan, Bozdech, Zbynek, Preiser, Peter Rainer, Yoon, Ho Sup, Lescar, Julien

“…Compared to the human FKBP12−FK506 complex reported earlier, the structure reveals structural differences in the β5−β6 segment that lines the FK506 binding site. The presence in PfFKBD of Cys-106 and Ser-109 (substituting for His-87 and Ile-90, respectively, in human FKBP12), which are 4−5 Å from the nearest atom of the FK506 compound, suggests possible routes for the rational design of analogues of FK506 with specific antiparasitic activity. …”
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Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers by Erickson, A, Figiel, S, Rajakumar, T, Rao, S, Yin, W, Doultsinos, D, Magnussen, A, Singh, R, Poulose, N, Bryant, RJ, Cussenot, O, Hamdy, FC, Woodcock, D, Mills, IG, Lamb, AD

“…We first performed in-silico comparisons of inferred and directly resolved SNV and CNV status, from single cancer cells, from three different cell lines. We found that inferred SNV phylogenies accurately recapitulate DNA phylogenies (entanglement = 0.097). …”

Antifungal efficacy of kenaf seed peptides mixture in cheese, safety assessment and unravelling its action mechanism against food spoilage fungi by Arulrajah, Brisha, Qoms, Mohammed S., Muhialdin, Belal J., Zarei, Mohammad, Hussin, Anis Shobirin Meor, Hasan, Hanan, Chau, De-Ming, Ramasamy, Rajesh, Saari, Nazamid

“…The safety assessment showed that KSPM maintained the proliferation of normal cell lines up to 30 mg/mL. The cell surface potential energy and hydrophobicity of fungi were altered due to the potent interactions between the peptides and the cell envelope, with KSPM causing significant fungal cell wall permeability and subsequent disruption of the cytoplasmic membrane integrity. …”
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Performance, heterosis and heritability in selected tropical maize single, double and three-way cross hybrids by Saleh, G.B., Abdullah, D., Anuar, A.R.

“…A series of tropical maize hybrids, involving 10 single, four double and four three-way crosses were evaluated with their parental inbred lines and three control varieties, at Universiti Putra Malaysia, Serdang, Malaysia, in a randomized complete block design, with three replications. …”
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When the Earth Breathes: An Anthology of Volcanic Urbanism by Carucci Alvarez, Maria Gabriela

“…Igneous landscapes, through the production of new basalt floors, rich soils and ocean intrusions, traverse and redefine property boundary lines and national coastlines, which extends beyond plan views and into sectional shifts. …”
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Concept-level sentiment analysis in the manufacturing industry by Teng, He Xu

“…Manufacturers can make use of this technology to improve quality control, standardization and maintenance through producing predictive analyzes of equipment functionality and radically streamlining factory lines. Manufacturing will continue to be an important pillar of Singapore’s economy. …”
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Diameter-free estimates for the quadratic Vinogradov mean value theorem by Mudgal, A

“…Consequently, our strategy differs from these two lines of approach, and we employ techniques from incidence geometry, arithmetic combinatorics and analytic number theory. …”

Ritual speech, performativity, and modality by Frangulov, AM

“…The incorporation of historical data from the ritual corpora of the Rigveda and Hittite ritual tablets, has not only enriched the quality of analysis through quantitative analysis, but it also provided catalysts for many of the discussions raised and many future lines of inquiry. In the examination of the facts of performativity in ritual speech, this thesis has shown that formal semantic consideration of this type of data can reveal many insights into performative speech as a whole. …”

Src family kinase expression and subcellular localization in macrophages: implications for their role in CSF‐1‐induced macrophage migration by Dwyer, AR, Mouchemore, KA, Steer, JH, Sunderland, AJ, Sampaio, N, Greenland, EL, Joyce, DA, Pixley, FJ

“…We report a comprehensive analysis of individual Src family kinase expression in macrophage cell lines and primary macrophages and demonstrate colony‐stimulating factor‐1–induced changes in Src family kinase subcellular localization, which provides clues to their distinct and redundant functions in macrophages. …”

Investigating the inner controls on explosive eruptions using textural analyses and petrology by Bernard, Olivier

“…Second I use apatite to finely study the volatile budgets and degassing rates of the magma batches that fed the sub-plinian, effusive and vulcanian phases of the 2006 Rabaul eruption. …”
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Causal Machine Learning to Discover Biochemical Determinants of Physical Fitness by Nawaz, Hesham

“…Identifying the key pathways relevant to cardiorespiratory fitness is of great importance for both predicting exercise responsiveness and potentially finding which interventions are likely to affect it. While contemporary deep learning models have demonstrated great success in pattern recognition and generation for various data modalities, their ability to decipher the causal mechanisms underlying these patterns is limited. …”
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Motor insurance in Singapore : problems and prescriptions by Ang, Cheng Sim, Lim, Siew Hui, Teo, Clarissa Suan Hoon

“…It emphasizes that immediate action is needed to avoid the erosion of profits from the motor insurance market. Furthermore, likely effects of the current situation are studied and this report attempts to recommend possible solutions to the problems.…”
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Culture as a research bias factor in bilingual markets. by Lee, Kin Man., Ong, Randall Choon Poh.

“…This poses a growing dilemma concerning the language in which marketing communications should be framed, as it seems likely that the use of a language could form a trigger that places a message recipient in a certain frame of mind. …”
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Carbene-catalyzed enantioselective oxidative coupling of enals and di(hetero)arylmethanes by Chen, Qiao, Zhu, Tingshun, Majhi, Pankaj Kumar, Mou, Chengli, Chai, Huifang, Zhang, Jingjie, Zhuo, Shitian, Chi, Robin Yonggui

“…To date, it remains challenging to functionalize the diaryl methyl sp3 carbon–hydrogen bond directly in an enantioselective manner. This is likely due to the relatively inert nature of the carbon–hydrogen bond and the difficult enantiofacial discrimination of two sterically similar aryl substituents. …”
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Evolutionary and ecological insights from Cytinus: a plant within a plant by de Vega, C, Thorogood, CJ, Albaladejo, RG, Rakotonasolo, F, Hobbhahn, N, Martos, F, Burgoyne, PM, Johnson, SD

“…Owing to this cryptic life cycle, the genus is poorly understood and is likely to include several hitherto undescribed species, particularly in threatened forest habitat in Madagascar. …”

Studies on high-frequency noise characteristics in deep submicron NMOSFETs by Zeng, Rong

“…The reduction of minimum noise figure with the increase in body bias may provide a possible methodology to finely adjust the device high-frequency noise performance for circuit design.…”
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VI-VS: calibrated identification of feature dependencies in single-cell multiomics by Boyeau, Pierre, Bates, Stephen, Ergen, Can, Jordan, Michael I., Yosef, Nir

“…VI-VS is available as an open-source Python package, providing a robust solution to identify features more likely representing genuine causal relationships.…”
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A new method for evaluating kinesthetic acuity during haptic interaction by Casadio, Maura, Squeri, V., De Santis, D., Zenzeri, J., Masia, L., Morasso, P.

“…Although proprioceptive impairment is likely to affect in a significant manner the capacity of stroke patients to recover functionality of upper limb, clinical assessment methods currently in use are rather crude, with a low level of reliability and a limited capacity to discriminate the relevant features of this severe deficit. …”
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Future failure rate prediction for transformers in power systems by Tan, Jia Le

“…Failure prediction is an important tool to estimate when these failures are likely to happen, which informs the replacement of transformers before a failure event. …”
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Certification of continuous professional development for librarians in Singapore by Choy, Fatt Cheong.

“…The paper discusses the philosophy and practical considerations behind its design, elaborate on the key components, address some issues raised by members of the community, outline the benefits to and impact on the professional community and finally discuss the likely challenges in its implementation.…”
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