High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Palafox, Marta, Monserrat, Laia, Bellet, Meritxell, Villacampa, Guillermo, Gonzalez-Perez, Abel, Oliveira, Mafalda, Brasó-Maristany, Fara, Ibrahimi, Nusaibah, Kannan, Srinivasaraghavan, Mina, Leonardo, Herrera-Abreu, Maria Teresa, Òdena, Andreu, Sánchez-Guixé, Mònica, Capelán, Marta, Azaro, Analía, Bruna, Alejandra, Rodríguez, Olga, Guzmán, Marta, Grueso, Judit, Viaplana, Cristina, Hernández, Javier, Su, Faye, Lin, Kui, Clarke, Robert B., Caldas, Carlos, Arribas, Joaquín, Michiels, Stefan, García-Sanz, Alicia, Turner, Nicholas C., Prat, Aleix, Nuciforo, Paolo, Dienstmann, Rodrigo, Verma, Chandra Shekhar, Lopez-Bigas, Nuria, Scaltriti, Maurizio, Arnedos, Monica, Saura, Cristina, Serra, Violeta

“…Here, we show that p16 overexpression is associated with reduced antitumor activity of CDK4/6 inhibitors in patient-derived xenografts (n = 37) and estrogen receptor-positive breast cancer cell lines, as well as reduced response of early and advanced breast cancer patients to CDK4/6 inhibitors (n = 89). …”
Get full text

Novel method of probe design for characterising unclassified microbial taxa in wastewater by Tan, Shi Ming

“…Shimingles; distinct clades were in line with two draft genomes recovered through genomic binning. …”
Get full text

InAlN/GaN high electron mobility transistors on Si for RF applications by Xing, Weichuan

“…Also, device geometries including gate length, line-to-space ratio of the nanostripchannel and gate-to-source distance have been studied. …”
Get full text
Get full text

Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures by Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J. Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., Goya-Maldonado, Roberto

Get full text

Cell charactetization in differnet regions of the native annulus fibrous in a porcine intervetebral disc model through cell sorting and molecular analysis by Teo, Tong

“…Current treatments include conservative ones such as the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for short term relief and surgical ones such as spinal fusion to alleviate pain caused by IVD degeneration. …”
Get full text

Innovative UWB phase shifters using groove gap-waveguide technology inspired by metasurfaces for beamforming networks operating at 100 GHz by Alibakhshikenari, Mohammad, Zidour, Ali, Virdee, Bal Singh, Kouhalvandi, Lida, Shahid, Saleem, See, Chan Hwang, Limiti, Ernesto

“…The metasurface features a "bed-of-nails" structure, where metal pins are connected to a bottom layer and spaced <λ/4 from a top plate. …”
Get full text

A Self-Polymerizing Mesh of Nano-Tethers for the Mechanical Constraint of Degraded Intervertebral Discs—A Review of 25 Years of Pre-Clinical and Early Clinical Research by Hedman, Thomas, Rogers, Adam, Beall, Douglas

“…It is intended that this review of a novel nano-scale material-based solution for mechanical deficiencies in biologically limited tissues may provide a helpful example for other innovations in spinal diseases and similarly challenging musculoskeletal disorders.…”
Get full text

Somatosensory and clinical profiles of patients with spine-related and clinical framework-based neck–arm pain by Kapitza, C, Ballenberger, N, Luedtke, K, Schmid, AB, Tampin, B

“…A recently developed mechanism-based clinical framework for spine-related pain distinguishes between spinally referred pain without neurological deficits (somatic referred pain, heightened nerve mechanosensitivity, radicular pain), with neurological deficits (radiculopathy), and mixed-pain presentations. …”

Effect of adding global postural re-education to Kendall exercises for treating asymptomatic forward head posture: a single-blinded randomized controlled trial by Abu-Taleb, Walaa, Yamany, Abeer Abdelrahman, Aneis, Yasser M., Abu El Kasem, Shimaa T.

“…Conclusions: The added effect GPR technique to Kendall exercises significantly improved CVA, CROM, NDI, chest expansion, and spinal mobility in subjects with FHP.…”
Get full text

3D spine shape estimation from single 2D DXA by Bourigault, E, Jamaludin, A, Zisserman, A

“…Consequently, extracting the spinal geometry in 3D would help quantify these spinal deformations and aid diagnosis. …”

Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories by Dai, Y, Zhong, Y, Liu, H, Pan, R, Yuan, L, Du, J, Li, M, Wang, X, Shi, C, Liu, G, Zhu, P, Shimeld, S, Zhou, X, Li, G

“…We characterized cell specification at the mechanistic level and generated mutant lines to examine the function of five key transcription factors involved in neural specification. …”

Development of concentration gradient generator by Wong, Liang Chen.

“…The general design of the devices included fluidic pressure balance between 4 fluidic sources with 2 sinks, and 4 fluidic sources with 4 sinks. Furthermore, a circular gradient generator with 4 fluidic sources and 2 sinks was also tested.…”
Get full text

Motion control (brushless DC motor) of a lower limb robotic orthosis for rehabilitation of stroke and incomplete SCI patients by Lim, Zhenhui

“…Strokes and spinal cord injuries (SCI) can cause motor malfunction to the patients resulting in the loss of the ability to walk. …”
Get full text

Immunotherapy-responsive neuropathic pain and allodynia in a patient with glycine receptor autoantibodies: a case report by Soleimani, B, Board, C, Yu, T, Tracey, I, Irani, SR, Foley, P

“…Glycine receptors are known to play a key role in inhibitory neurotransmission in the spinal dorsal horn and have therefore been considered as targets for analgesic development. …”

Distinct movement disorders in contactin-associated-protein-like-2 antibody-associated autoimmune encephalitis by Gövert, F, Abrante, L, Becktepe, J, Balint, B, Ganos, C, Hofstadt-van Oy, U, Krogias, C, Varley, J, Irani, SR, Paneva, S, Titulaer, MJ, de Vries, JM, Boon, AJW, Schreurs, MWJ, Joubert, B, Honnorat, J, Vogrig, A, Ariño, H, Sabater, L, Dalmau, J, Scotton, S, Jacob, S, Melzer, N, Bien, CG, Geis, C, Lewerenz, J, Prüss, H, Wandinger, K-P, Deuschl, G, Leypoldt, F

“…Further distinct movement disorders include isolated and combined segmental spinal myoclonus and autoimmune episodic ataxia.</p>…”

Home automation system using Raspberry Pi by Wang, Yangyang

“…Through out this project, student will gain knowledge in areas such as understand Raspberry Pi’s background; Raspberry Pi’s command lines; how to control GPIO pins; how to use PuTTY to remotely access the Raspberry Pi; understand web server Apache and PHP; understand WinSCP and how to transfer files with it; have the knowledge of web interface design, understand HTML5, CSS, PHP and JavaScript and be able to do electrical wiring and mechanical modification for the equipment required in the project.…”
Get full text

Experimental and numerical studies on the cooling of mobile device by Setoh, Guojing.

“…With an increase of internal fins, the maximum temperature of the heat sinks and plastic casing can be maintained at a lower temperature. …”
Get full text

The Korean question : an unresolved issue of Asia’s cold war by Chew, Emrys

“…The sinking of the Cheonan is emblematic of a Korean War that was never formally concluded. …”
Get full text
Get full text

Challenges and opportunities for physiologically controlled therapy in neural systems by Marks, VS, Piper, RJ, Van Rheede, JJ, Benjaber, M, Green, AL, Tisdall, MT, Denison, TJ

“…The utility of such a bidirectional application is exemplified by the success of the NeuroPace responsive neuro stimulation (RNS) device in the reduction of seizures [1] and pivotal trials of spinal cord stimulation for chronic leg pain using evoked compound action potentials to facilitate a homeostatic feedback system [2] .…”

Accuracy of thoracolumbar pedicle screw insertion based on routine use of intraoperative imaging and navigation by Sundaram, Pirateb Paramasivam Meenakshi, Oh, Jacob Yoong-Leong, Tan, Mark, Nolan, Colum Patrick, Yu, Chun Sing, Ling, Ji Min

“…Overview of Literature: The use of 3D intraoperative imaging and navigation in spinal surgery is aimed at improving the accuracy of pedicle screw insertion. …”
Get full text