Synergistic effect of 5-fluorouracil and the small molecule Wnt/β-catenin inhibitor iCRT3 on Caco-2 colorectal cancer cells in vitro by Smarslik, Maren, Inal, Jameel

“…In this study, the cytotoxic effects of 5-FU and iCRT3 were investigated using the Caco-2 colon adenocarcinoma cell line, marking the first investigation of their combined effects. …”
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Content learning in Japanese and English medium instruction: comparing chemistry learning outcomes in Japanese higher education by Aizawa, I

“…<p>English Medium Instruction (EMI) is rapidly gaining momentum in line with internationalisation of higher education trends. …”

An analysis of contact stiffness and frictional receding contacts by Parel, KS

“…Then, a fundamental 2D frictional receding contact problem involving a homogeneous linear elastic infinite layer pressed by a line load onto a half-plane of the same material was analysed. …”

The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. However, if a short course of biologics can rapidly suppress inflammation allowing treatment to be withdrawn and response maintained on methotrexate, this may be a cost-effective model for early use.…”

Implementing strategies to improve uptake of patient-reported outcome measures (PROMs) in gender-affirming care: a mixed-methods implementation study by Kamran, R, Jackman, L, Goodwin, C, Laws, A, Stepney, M, Harrison, C, Jain, A, Rodrigues, J

“…</p> <p><strong>Main outcome(s) and measure(s)</strong> Response rates were calculated at 2-week intervals, in line with the deployment of each implementation strategy. …”

Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The aim of this study was to evaluate the in vitro activities of ethanolic extract of Tinospora crispa (EETC) on protein kinases involved in the lytic cycle of T. gondii infection in Vero cell line. The EETC was obtained through the maceration of dried stem powder. …”
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Identification of novel functional compounds from forest onion and its biological activities against breast cancer by Nurkolis, Fahrul, Kurniatanty, Isma, Wiyarta, Elvan, Permatasari, Happy Kurnia, Mayulu, Nelly, Taslim, Nurpudji Astuti, Tjandrawinata, Raymond Rubianto, Hardinsyah, Hardinsyah, Tallei, Trina Ekawati, Tsopmo, Apollinaire, Radu, Son, Hadinata, Edwin, Kim, Bonglee, Ribeiro, Rosy Iara Maciel Azambuja, Syahputra, Rony Abdi

“…Therefore, this study focuses on metabolite profiling, in silico or pharmacoinformatic activity and mechanisms, as well as advanced validation on in vitro cell lines. Ten compounds identified in E. bulbosa bulb ethanolic extract (EBE) showed cancer receptor and radical inhibitory activity via network pharmacology and molecular docking simulation. …”
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Design, synthesis and activity studies of antifreeze peptide derived from type I shorthorn sculpin by Asmawi, Azren Aida

“…Furthermore, these peptides have been proved to be non-cytotoxic on 3T3 cell line with IC50 value >100 μg/mL and have a positive impact on ice crystal growth in ice cream mixes. …”
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Attitudinal Factors of Fishermen Trapped in the B40 Category: an Empirical Study by Mustafar, Mastora, Mat Yamin, Fadhilah, Mohamed Ismail, Risyawati, Mohd Nawi, Nur Syazwani, Abu Bakar, Siti Zakiah, Johari, Ayub

“…However, its importance is not in line with the well-being of key players in the fishing industry itself, especially Zone A fishermen who are mostly in the Bottom 40% (B40) of household income category. …”
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Natural robustness of machine learning in the open world by Wei, Hongxin

“…Besides, we provide the first attempt to utilize out-of-distribution data to rebalance the class priors of long-tailed datasets and study the effect of out-of-distribution data on the learned representations in long-tailed learning. …”
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Outcomes of shoulder replacement surgery in routine care by Craig, RS

“…</p> <p>Hospital Episode Statistics data were used to calculate the risks of long-term revision and early serious adverse events. …”

The influence of pregnancy complications on fetal and neonatal cardiovascular development by Aye, C

“…<p>It is becoming increasingly clear that exposure to pregnancy complications such as hypertensive disorders of pregnancy and premature birth (birth before 37 weeks gestation) have a long term and specific effect on future cardiovascular disease development and risk in the offspring. …”

Swimming in Data by Douglass, Katherine, Lamb, Augustus, Lu, Jerry, Ono, Ken, Tenpas, William

“…Ladies and Gentlemen, this is the Olympic Final,” thunders from the loudspeakers, yet it is barely audible over the deafening roar of a crowd ten thousand strong. One long blast of the referee’s whistle summons eight of the world’s fastest swimmers to the starting blocks. …”
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Interpreting Photoactive Fluorescence Microscopy Measurements of Steady-State Actin Dynamics by Tardy, Y., McGrath, J.L., Hartwig, J.H., Dewey, C.F.

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Highly reliable carbon nanotube-based composite fibers cross-linked by a 3D polymer network by Sun, Gengzhi, Zheng, Lianxi, Zhan, Zhaoyao, Jiang, Chunbo, Hansen, Reinack V., Khor, Yengpeng, Pang, John Hock Lye

“…However, CNTs inside a CNT fiber slide considerably during static and cyclic tensile tests, which is unfavorable for long-term performances. In this study, a second phase has been introduced into CNT fiber in order to enhance its reliability.…”
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Foreign exchange prediction and trading using low-shot machine learning by Faris Ahmad Ishak

“…A comparison study has also been done using a built meta-learner Long Short Term Memory(LSTM) to forecast the same exchange rate. …”
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Suitability of TCLP for cement-based products by Shen, Aldwin Weishun.

“…This is particularly important for the assessment of the long term leaching characteristic after the ANC of the waste is exhausted. …”
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Development of a safety monitoring system in building construction by Yeni Susanti

“…Long term impact from sustaining back injury is expected. …”
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China's engagement with the liberal international order by Chua, Ze Ping

“…The paper argues that China avoids radically challenging the order’s rules by challenging them in a calibrated way to avoid being regarded as a ‘rule breaker’. In the long run, China desires to amend the order’s rules in its favour while also seeking to reduce the impact of US dominance through achieving technological independence and closer ties with neighbouring states.…”
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Erotica in Australian libraries : are we negligent collection managers? by Crook, Edgar

“…Literary erotica has existed alongside erotic art and sculpture for as long as there has been the capacity to publish or otherwise transmit the written word. …”
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