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    Metal-organic framework-based nanovaccine for relieving immunosuppressive tumors via hindering efferocytosis of macrophages and promoting pyroptosis and cuproptosis of cancer cells by Liu, Yang, Niu, Rui, Zhang, Xiaodong, Zhang, Bin, Chen, Xiaokai, Guo, Jingjing, Song, Shuyan, Wang, Yinghui, Zhang, Hongjie, Zhao, Yanli

    Published 2024
    “…Once inside the early endosome, the alkaline phosphatase overexpressed in the tumor cells' membrane activates the in situ type I photodynamic effect of Cu-THBQ/AX for generating •O2-, and the Cu-THBQ/AX catalyzes O2 and H2O2 to •O2- and •OH via semiquinone radical catalysis and Fenton-like reactions. This surge of ROS in early endosomes triggers caspase-3-mediated proinflammatory pyroptosis via activating phospholipase C. …”
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    Journal Article
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