Towards an optimal and unbiased approach for tumor cell isolation by Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Chung, Wong Chee, Puiu, Poenar Daniel, Rahman, Abdur Rub Abdur

“…This approach achieves an average of >90 % recovery of spiked tumor cells and >99 % total WBC depletion in whole blood across multiple cell lines, in a simple and easy-to-use assay. The results presented herein and ongoing improvements aim to fulfill the need for a highly reliable, unbiased, standardized, and optimized CTC isolation platform, using component technologies that are validated for cell isolation.…”
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Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype–anti-idiotype Fab complex by Wong, Yee Hwa, Goh, Boon Chong, Lim, She Yah, Teo, En Wei, Lim, Angeline P. C., Dedon, Pete C., Hanson, Brendon J., MacAry, Paul A., Lescar, Julien

“…The crystal structure at a resolution of 2.5 Å of a complex between the Fab fragments of E1 and HM14c10 provides the first detailed molecular comparison of an anti-idiotype paratope specific for a human antibody with its analogous epitope, a discontinuous quaternary structure located at the surface of the viral particle that spans adjacent envelope (E) proteins. This comparison reveals that the footprints left by E1 and E on HM14c10 largely overlap, explaining why the formation of binary complexes is mutually exclusive. …”
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis by Kim, Minyoung E.

“…The framework, termed MorPheT (Morphology Phenotyping Tool), serves as an all-in-one solution, offering a suite of analysis modules spanning from image pre-processing to precise cell detection, atlas alignment, morphological phenotyping, and interactive visualizations. …”
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Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…This paper shares an innovative approach to crowdsourcing user data to collect otherwise inaccessible Amazon purchase histories, spanning 5 years, from more than 5,000 U.S. users. …”
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Computational Approaches for Understanding and Redesigning Enzyme Catalysis by Karvelis, Elijah

“…In this thesis, I address these shortcomings by developing and demonstrating computational strategies comprised of techniques spanning statistical mechanics, machine learning, and protein design, and I apply them to the enzyme ketol-acid reductoisomerase (KARI), whose economic viability for the production of isobutanol would be strengthened by enhancing its activity on one of its two native substrates: 2-acetolactate (ACL). …”
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Moris Mai : to be born by Cai, Yun, Har, Jiawei, Loh, Jing Ting, Toh, Yan Wei

“…Production of the documentary took place from July 2011 to March 2012, spanning across different districts in Timor-Leste, from the capital, Dili to Oecussi, a coastal enclave separated from Timor-Leste by West Timor. …”
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Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…Ultimately, 74 studies met inclusion criteria and spanned from 2001 to 2024, with the majority (64 studies; 86%) published between 2014 and 2024. …”

Ethnicity and anthropometric deficits in children: A cross-sectional analysis of national survey data from 18 countries in sub-Saharan Africa by Tusting, LS, Mishra, S, Gibson, HS, Lindsay, SW, Weiss, DJ, Flaxman, S, Bhatt, S

“…The study population comprised 138,312 children spanning 45 ethnic groups across 18 countries. In pairwise comparisons (accounting for multiple comparisons) between ethnic groups, height-for-age z-scores differed by at least 0.5 standard deviations in 29% of comparisons, weight-for-height z-scores in 36% of comparisons and weight-for-age z-scores in 20% of comparisons. …”

The COVID guidelines India project: a rapid living evidence synthesis during a pandemic in a LMIC setting by Singh, B, Alexander, H, Tharyan, P, Mathew, JL, Covid Management Guidelines India Group, Garner, P, Rupali, P, Core Committee, Rupali, P, Ryan, H, Steering Committee, Methodology Committee, External Advisory Panel, Expert Working Group – Antiviral, Expert Working Group – Anti-inflammatory, Expert Working Group - Antibody, Expert Working Group - Anticoagulation, Expert Working Group - Respiratory support, Expert Working Group - Other Supportive Therapy, Evidence Synthesis Team, Dissemination Team

“…</p> <br> <p><strong>Results:</strong> Since May 2021, a total of 20 guidelines have been developed spanning pharmacological, respiratory and other supportive interventions for management of COVID-19, with over 83,600 unique page views up to December 2023. …”

Peroxisome proliferator-activated receptors and caloric restriction-common pathways affecting metabolism, health, and longevity by Duszka, Kalina, Gregor, András, Guillou, Hervé, König, Jürgen, Wahli, Walter

“…Consequently, several lines of evidence suggest that PPARs might be indispensable for beneficial outcomes related to CR. …”
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Viral content: a theory of vaccine hesitancy based on information encountering in the greater Manila area, Philippines by Sacramento, Simon Philip R., Sipin, Ian Dominic P.

“…Background: Ground experiences of the researchers indicate substantial concern about the side-effects of the AstraZeneca vaccine in some individuals who lined up to get vaccinated. The Philippine Department of Health, Food and Drug Administration temporarily suspended the administration of the AstraZeneca vaccine to persons below 60 years old on April 8, 2021, due to reports of “rare cases of blood clots with low platelets detected in some individuals inoculated with the vaccine.” …”
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To study the commercial and operational advantages and disadvantages of mega-container ships (>14,000TEU) by Lai, Marie Jinbao

“…In order to bring down the per-unit cost of transporting the containers, many shipping lines have began to order container vessels with increased container carrying capacity. …”
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Gambling island : a look at Singapore Pools and its role on gambling in Singapore society by Ang, Darren

“…Through qualitative research, I then try to show that Singapore Pools has managed to “diffuse” itself into the daily lives of Singaporeans, blurring the lines between institutional gambling and social gambling and further sustaining both institutional gambling as well as social gambling.…”
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When east meets west: beauty standards and ideals in Singapore by Dhillon, Sasha Kaur

“…Through my interviews, I discovered that Singapore constructs along unique lines – intertwining both Eastern and Western cultures with heavy emphasis on themes like skin colour, gender and race. …”
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Mapping refuse profile in Singapore old dumping ground through electrical resistivity, S-wave velocity and geotechnical monitoring by Yin, Ke, Tong, Huan Huan, Noh, Omar, Wang, Jing-Yuan, Giannis, Apostolos

“…Data were analyzed using an orthogonal set of plots by spreading 24 lines in two perpendicular geophone-orientation directions. …”
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Biomateriality and organizing: towards an organizational perspective on food by Moser, C, Reinecke, J, Hond, FD, Svejenova, S, Croidieu, G

“…We use this analytical toolkit to introduce the different articles in the special issue and put forward some lines of future research.…”

A bi-functional three-terminal memristor applicable as an artificial synapse and neuron by Liu, Lingli, Dananjaya, Putu Andhita, Ang, Calvin Ching Ian, Koh, Eng Kang, Lim, Gerard Joseph, Poh, Han Yin, Chee, Mun Yin, Lee, Calvin Xiu Xian, Lew, Wen Siang

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GWTC-2.1: Deep extended catalog of compact binary coalescences observed by LIGO and Virgo during the first half of the third observing run

“…We also expand the population of binaries with significantly asymmetric mass ratios reported in GWTC-2 by an additional two events (the mass ratio is less than 0.65 and 0.44 at 90% probability for GW190403_051519 and GW190917_114630 respectively), and find that two of the eight new events have effective inspiral spins χ eff > 0 (at 90% credibility), while no binary is consistent with χ eff < 0 at the same significance. …”
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Laser-based 3D printing using bessel beams for tissue engineering applications by Liew, Andy Wen Loong

“…High resolution fibers down to 25 μm were printable using the BB technique, a significant improvement compared to conventional microfluidics and wet spinning techniques, and the capability to tune the fabricated fiber diameter based on mathematical models was also demonstrated. …”
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Gut microbiota in colorectal cancer: biological role and therapeutic opportunities by Pandey, Himani, Tang, Daryl W. T., Wong, Sunny Hei, Lal, Devi

“…While CRC is thought to be an interplay between genetic and environmental factors, several lines of evidence suggest the involvement of gut microbiota in promoting inflammation and tumor progression. …”
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