Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…<p><strong>Background:</strong> A blood-stage Plasmodium falciparum malaria vaccine would provide a second line of defence to complement partially effective or waning immunity conferred by the approved pre-erythrocytic vaccines. …”

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Palafox, Marta, Monserrat, Laia, Bellet, Meritxell, Villacampa, Guillermo, Gonzalez-Perez, Abel, Oliveira, Mafalda, Brasó-Maristany, Fara, Ibrahimi, Nusaibah, Kannan, Srinivasaraghavan, Mina, Leonardo, Herrera-Abreu, Maria Teresa, Òdena, Andreu, Sánchez-Guixé, Mònica, Capelán, Marta, Azaro, Analía, Bruna, Alejandra, Rodríguez, Olga, Guzmán, Marta, Grueso, Judit, Viaplana, Cristina, Hernández, Javier, Su, Faye, Lin, Kui, Clarke, Robert B., Caldas, Carlos, Arribas, Joaquín, Michiels, Stefan, García-Sanz, Alicia, Turner, Nicholas C., Prat, Aleix, Nuciforo, Paolo, Dienstmann, Rodrigo, Verma, Chandra Shekhar, Lopez-Bigas, Nuria, Scaltriti, Maurizio, Arnedos, Monica, Saura, Cristina, Serra, Violeta

“…Here, we show that p16 overexpression is associated with reduced antitumor activity of CDK4/6 inhibitors in patient-derived xenografts (n = 37) and estrogen receptor-positive breast cancer cell lines, as well as reduced response of early and advanced breast cancer patients to CDK4/6 inhibitors (n = 89). …”
Get full text

Observation of flat bands and Dirac cones in a pyrochlore lattice superconductor by Huang, Jianwei, Setty, Chandan, Deng, Liangzi, You, Jing-Yang, Liu, Hongxiong, Shao, Sen, Oh, Ji Seop, Guo, Yucheng, Zhang, Yichen, Yue, Ziqin, Yin, Jia-Xin, Hashimoto, Makoto, Lu, Donghui, Gorovikov, Sergey, Dai, Pengcheng, Denlinger, Jonathan D., Allen, J. W., Hasan, M. Zahid, Feng, Yuan-Ping, Birgeneau, Robert J., Shi, Youguo, Chu, Ching-Wu, Chang, Guoqing, Si, Qimiao, Yi, Ming

Get full text

Novel method of probe design for characterising unclassified microbial taxa in wastewater by Tan, Shi Ming

“…Shimingles; distinct clades were in line with two draft genomes recovered through genomic binning. …”
Get full text

InAlN/GaN high electron mobility transistors on Si for RF applications by Xing, Weichuan

“…Also, device geometries including gate length, line-to-space ratio of the nanostripchannel and gate-to-source distance have been studied. …”
Get full text
Get full text

Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures by Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J. Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., Goya-Maldonado, Roberto

Get full text

Innovative UWB phase shifters using groove gap-waveguide technology inspired by metasurfaces for beamforming networks operating at 100 GHz by Alibakhshikenari, Mohammad, Zidour, Ali, Virdee, Bal Singh, Kouhalvandi, Lida, Shahid, Saleem, See, Chan Hwang, Limiti, Ernesto

“…The metasurface features a "bed-of-nails" structure, where metal pins are connected to a bottom layer and spaced <λ/4 from a top plate. …”
Get full text

A three dimensional kinematic method for determining the effectiveness of arm segment rotations in producing clubhead speed by Teu, Koon Kiat

Get full text

Home automation system using Raspberry Pi by Wang, Yangyang

“…Through out this project, student will gain knowledge in areas such as understand Raspberry Pi’s background; Raspberry Pi’s command lines; how to control GPIO pins; how to use PuTTY to remotely access the Raspberry Pi; understand web server Apache and PHP; understand WinSCP and how to transfer files with it; have the knowledge of web interface design, understand HTML5, CSS, PHP and JavaScript and be able to do electrical wiring and mechanical modification for the equipment required in the project.…”
Get full text

Effect of dopant solubility and excess doping on the superconducting properties of doped Nb3Sn prepared by field assisted sintering technique by Srivastava, N, Matthews, GAB, Liu, J, Speller, SC, Grovenor, CRM, Santra, S

“…The Y₂O₃&nbsp;particles was also considered as a possible cause of pinning down of grain boundaries in addition to NbO leading to grain refinement through Zener pinning. …”

Using surface markers to describe the kinematics of the medial longitudinal arch in a longitudinal study of flexible flat feet and health-related quality of life by Uhan, J

“…In particular, limitations in forefoot supination and hindfoot dorsiflexion may be predictors of poorer QofL in adulthood.…”

Spintronics devices for neuromorphic computing by Tang, Shawn Zhen Kee

“…To solve this, we discuss the possibility of using a geometrically pinned magnetic domain wall memory device that utilises anti-notches for pinning, as the free layer of an MTJ, for future use in a three-terminal MRAM. …”
Get full text

Target Design and Optimizations for Spent Fuel Transmutation by Tukharyan, Grigor

“…A proposed tank design with a lead/Tc-99 target that is surrounded by LLFP pins and heavy water is considered for the spallation study. …”
Get full text

Dynamics of three-dimensional helical domain wall in cylindrical NiFe nanowires by Wong, De Wei, Chandra Sekhar, M., Gan, Wei Liang, Purnama, Indra, Lew, Wen Siang

“…A minimum current density is needed to overcome an intrinsic pinning to drive the helical DW, and the propagation along the nanowire is accompanied by a rotational motion. …”
Get full text
Get full text

Application for motorised video sliding kit by Gao, Cheng

“…Arduino is used to control Pan and Tilt Head and servo motor through PWM pins. At the end of this project, an integrated solution to automate time-lapse photography is developed. …”
Get full text

Bilayer skyrmion dynamics on a magnetic anisotropy gradient by Ang, Calvin Ching Ian, Gan, Weiliang, Lew, Wen Siang

“…Furthermore, the analytical model also provides insights into the dynamics of skyrmion pinning and relaxation of asymmetric skyrmion pairs in bilayer-coupled skyrmion systems.…”
Get full text
Get full text

Emergent vortices at a ferromagnetic superconducting oxide interface by Petrović, A P, Paré, A, Paudel, T R, Lee, K, Holmes, S, Barnes, C H W, David, A, Wu, T, Tsymbal, E Y, Panagopoulos, C

“…This hysteresis is argued to arise from vortex depinning within a thin (< 20 nm) superconducting layer, mediated by discrete ferromagnetic dipoles located solely above the layer. The pinning strength may be modified by varying the superconducting channel thickness via electric field-effect doping. …”
Get full text
Get full text

Goblet cell differentiation in colorectal cancer by Abdullayeva, G

“…These groups included high, medium, and low MUC2/TFF3-expressing cell lines, cell lines with no/very low MUC2 but high TFF3 expression, and cell lines completely lacking these proteins. …”

Improving gene therapy by Wang, Eliza Lisha

“…Existing PT67 and Amphotropic-Phoenix retroviral packaging cell lines can be made more efficient to produce higher retroviral titers, giving rise to more efficient gene transfer. …”
Get full text

Progressive collapse of reinforced concrete building structures by Dat, Pham Xuan

“…The associated rotationally-restrained but laterally-unrestrained boundary condition of the test specimens was effected by a set of pinned-end supporting columns. Uniformly distributed loads were simulated by a twelve-point loading system. …”
Get full text