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    Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

    Published 2024
    “…Using commonly prescribed TK inhibitors (TKIs), I show that TK genetic status generally predicts whether or not a cell line will show any response to genotype-matched TKI (GM-TKI), but is insufficient to predict drug tolerance, the ability of a cell line to sustain proliferation under drug. …”
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