A novel human stem cell platform for probing adrenoceptor signaling in iPSC derived cardiomyocytes including those with an adult atrial phenotype by Ahmad, F

“…</p> <p>Drug targeting of atrial-specific ion channels has been difficult because of lack of availability of appropriate cardiac cells, and preclinical testing studies have been carried out in non-cardiac cell lines, heterogeneous cardiac populations or animal models that have been unable to accurately represent human cardiomyocyte physiology. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Steady and unsteady casing static pressure measurements were acquired, using pneumatic lines and high-frequency response (∼100 kHz) Kulite pressure transducers respectively. …”

Inflammation and colorectal cancer: elucidation of the cellular and molecular mechanisms by which interleukin 22 contributes to the development and progression of colorectal cancer by McCuaig, S

“…Using a panel of CRC cell lines and primary human organoids, we confirmed that this prognostic association is due to a functional interaction between IL-22 and mutant KRAS by observing that IL-22 enhances chemoresistance, 3-dimensional clonogenicity, and proliferation specifically in CRC cells with both high IL-22 receptor levels and <em>KRAS</em> mutations. …”

Assessing the kinetics of oxygen-unloading from red cells using FlowScore, a flow-cytometric proxy of the functional quality of blood by Rabcuka, J, Smethurst, P, Dammert, K, Saker, J, Aran, G, Walsh, G, Tan, J, Codinach, M, McTaggart, K, Marks, D, Bakker, S, McMahon, A, Di Angelantonio, E, Roberts, D, Blonski, S, Korczyk, P, Shirakami, A, Cardigan, R, Swietach, P

“…Applying FlowScore to data from the COMPARE study revealed a positive association with the time-delay from sample collection to measurement, which was verified experimentally. The LifeLines dataset revealed age, sex, and smoking among factors affecting FlowScore. …”

Dress, Feminism, and British New Woman Novels by Allen-Johnstone, C

“…For example, Grand elevated cross-class feminism, but she belittled middle-class women's taste, side-lined poor women’s most pressing sartorial concerns, and dressed to impress. …”

Age-related bone loss is associated with FGF21 but not IGFBP1 in healthy adults by Lee, Shuen Yee, Fam, Kai Deng, Chia, Kar Ling, Yap, Margaret M. C., Goh, Jorming, Yeo, Kwee Poo, Yap, Eric Peng Huat, Chotirmall, Sanjay Haresh, Lim, Chin Leong

“…The purpose of this study was to explore the FGF21-regulatory axis in bone turnover and the age-related decline in bone mineral density (BMD). Twenty ‘genetically linked’ family (parent and child) pairs were recruited. …”
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Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling by Vinaiphat, Arada, Pazhanchamy, Kalailingam, JebaMercy, Gnanasekaran, Ngan, SoFong Cam, Leow, Melvin Khee-Shing, Ho, Hee Hwa, Gao, Yong-Gui, Lim, Kah-Leong, Richards, A. Mark, de Kleijn, Dominique P. V., Chen, Christopher P., Kalaria, Raj N., Liu, Jian, O'Leary, Deborah D., McCarthy, Neil E., Sze, Siu Kwan

“…Background: Considerable evidence links dietary salt intake with the development of hypertension, left ventricular hypertrophy, and increased risk of stroke and coronary heart disease. …”
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Complexities of the San Andreas fault near San Gorgonio Pass : implications for large earthquakes by Yule, Doug, Sieh, Kerry

“…We infer that this step has been produced by slip on the linked San Gorgonio Pass-Garnet Hill-Coachella Valley Banning (SGP-GH-CVB) fault. …”
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The relation of nasopharyngeal colonization by Streptococcus pneumoniae in comorbid adults with unfavorable outcomes in a low-middle income country by Olivella-Gomez, J, Lozada, J, Serrano-Mayorga, CC, Méndez-Castillo, L, Acosta-González, A, Viñán Garcés, AE, Bustos, IG, Ibáñez-Prada, ED, Fuentes, YV, Crispin, AM, Garcia-Garcia, EY, Santana, E, Josa, DF, Pulido Saenz, J, Rodíguez-Castaño, GP, Rodríguez Orjuela, JA, Jaimes, D, Tettelin, H, Orihuela, CJ, Reyes, LF

“…While Spn colonization in children is linked to LRTI, its prevalence, and consequences in adults with comorbidities remain uncertain. …”

Unveiling potential therapeutic targets for breast cancer recurrence: differentially expressed genes and pathways in post-surgery patients by Hamad, Hamad Ali, Saeed, Hammad Khalaf, Hussein, Talib Hammad, Hussain, Abdalwahab Bdewi, Md Hashim, Nur Fariesha

“…The aim of this research is to find out the fundamental genes linked with progression of cancer that may play a critical role in breast cancer recurrence. …”
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The biggest challenges resulting from the COVID-19 pandemic on gender-related work from home in biomedical fields—world-wide qualitative survey analysis by Bezak, Eva, Carson-Chahhoud, Kristin V., Marcu, Loredana G., Stoeva, Magdalena, Lhotska, Lenka, Barabino, Gilda A., Ibrahim, Fatimah, Kaldoudi, Eleni, Lim, Sierin, Da Silva, Ana Maria Marques, Tan, Peck Ha, Tsapaki, Virginia, Frize, Monique

“…Participants reported increased domestic duties, blurred lines between home and work, and long workdays. Finding adequate workspace was a problem, and adaptations were necessary, especially when adults shared the same setting for working and childcare. …”
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Exploring the trait plasticity of ipa1-2d and qpl6 under different nitrogen treatments and heading periods by Zhuang, Wenshu, Jin, Guangyang, Zou, Yiting, Bian, Zhong, Xie, Dong, Zhang, Shuwei, Yeilaghi, Hadi, Yu, Liangliang, Wong, Muiyun, Fan, Xiaolei, Zhao, Dongsheng, Liu, Qiaoquan, Zhang, Lin

“…QTL analysis could elaborate on the environmental impact on trait plasticity using nearly isogenic lines (NILs) of different QTLs. Two QTLs, ipa1-2D and qPL6 are identified to have pleio-tropic contributions to panicle size and plant architecture, but their responses to different growth conditions are still unclear. …”
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Alive Scene: Participatory Multimodal AI Framework for Collective Narratives in Dynamic 3D Scene by Cheng, Chi-Li

“…The Alive Scene System integrates two advanced techniques: 3D scene reconstruction using Gaussian splatting, and semantic linking of human perceptions through the Contrastive Language-Image Pretraining (CLIP) model. …”
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Photocatalysis in a New Light: A Biohybrid Approach for Improved Reactivity with Tunable, Low-Energy Light Excitation by Cesana, Paul T.

“…A conjugate composed of a covalently linked photoenzyme and light antennae separates light capture from catalysis. …”
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Towards a Single Bio-molecule Detector Based on CMOS Nanofluidic Platform by Zikrallah, Ahmed S.

“…Ideally, we would be able to continuously monitor the secretome of these cell therapies as they are transformed and expanded in manufacturing.However, state-of-theart techniques for monitoring typically low concentrations of cytokines require either Mass Spectroscopy (MS) or immunoassays like Enzyme-linked Immunosorbent Assay (ELISA). We propose the use of CMOS technology to build a proteomic platform with a single biomolecule resolution. …”
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Leveraging the Properties of Aprotic Solvents Towards Efficient Electrocatalytic Carbon Dioxide Reduction by Chu, An T.

“…We leverage the unique solvation environments and equilibrium acidities accessible in such media to overcome key limitations to reaction performance that are intrinsically linked to the use of aqueous electrolytes. We demonstrate key principles for tuning aprotic solvent-based electrolytes towards improving carbon dioxide electroreduction catalysis, establishing the foundation for the development of advanced electrolyte designs. …”
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Reduction of dimensionality of a cellular actuator array for driving a robotic hand by Cho, Kyu-Jin, Ph. D. Massachusetts Institute of Technology

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Numerical modeling of motion and deformation of cells in microscale hydrodynamic and electric fields by Ye, Ting

“…As the first academic achievement made in this thesis, the two novel numerical methods are developed to efficiently treat the two-fluid model, namely the modified particle binary level set (MPBLS) method for tracking the cell membrane, and the modified semi-implicit method for pressure linked equations-revised (modified SIMPLER). • The MPBLS method employs the binary level set function to distinguish different materials, and further scatters a number of Lagrangian particles on the interface to correct the interface and provide the interface information. …”
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Maritime clusters and their development interplay with ports by Zhang Wei

“…Thus the promotion of maritime clusters has been taken as an important policy tool when considering an array of linked sectors in the maritime industry from the network perspective. …”
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Transition metal doped apatites as inert non-toxic pigments by Seah, Jasmine Si Han

“…The CaO6 columns and PO4 groups linked together forms in a honeycomb hexagonal network with one-dimensional channels extending through the structure. …”
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