Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper by Ranger, TA, Burchardt, J, Clift, AK, Mei, WX, Coupland, C, Tan, PS, Dixon, S, Cardwell, CR, Hippisley-Cox, J

“…We intend to the submit the findings for peer-reviewed publication in an academic journal and disseminate them to the public through Cancer Research UK.…”

Factors influencing macrophage phagocytosis and killing of Gram negative bacteria by Kurzyp, K

“…I showed that the effect of the GPR84 agonist 6-OAU was GPR84 specific in murine macrophages; in human macrophages, all three novel agonists tested were GPR84 specific.</p> <p>My findings provide novel tools and insights into factors involved in the interaction of <em>N. gonorrhoeae</em> and <em>E. coli</em> with macrophages, and suggest how macrophage receptors could be exploited to enhance bacterial killing for immune adjuvant therapy of infection.…”

Mobilising stone: investigating relations of materiality, movement and corporality in Holocene Saharan rock-art by Waldock, V

“…</p> <p>Other significant findings include detailed information on the role and identity of the image-maker, revisionist data on the amount of effort and skill expended in carving processes, and an examination of the ways in which rock-art was used to manifest social emotional concerns. …”

Symptom flares in women with chronic pelvic pain: questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)) by Coxon, L, Lugt, C, Horne, AW, Evans, E, Abreu- Mendes, P, Arendt-Nielsen, L, Aziz, Q, Becker, CM, Birch, J, Charrua, A, Demetriou, L, Ferreira-Gomes, J, Hoffman, A, Hummelshoj, L, Krassowski, M, Lunde, CE, Meijlink, J, Missmer, SA, Perro, D, Zondervan, KT, Sieberg, CB, Cruz, F, Nagel, J, Vincent, K

“…Clinical practice should include an enquiry into flares with the aim of finding strategies to lessen their burden.</p>…”

Better floors, better health: a theory of change for an improved household flooring intervention in rural communities in Kwale and Bungoma counties, Kenya by Kepha, S, Legge, H, Halliday, KE, Ochwal, V, Elson, L, Mwongeli, J, Oswald, WE, Kakoi, B, Wambua, J, Mwandawiro, C, Fillinger, U, Pullan, R, Njomo, D

“…This paper presents the findings from a theory of change development process that was undertaken as part of the formative research phase of the SABABU project. …”

Legal politics in the Libyan constitution-making process by van Lier, F

“…Both scholars and practitioners assume that legal procedures and standards of constitution-making provide structures for resolving potentially violent political contest and debate, and thereby contribute to reconciliation and consensus finding. It is hoped that such processes will amplify commonality and strengthen democracy in a state. …”

Privacy: a political approach by Bogue, RC

“…It can thus be shown that a commitment to democracy entails a commitment to certain privacy rights—a finding that circumvents the difficulty in establishing a common basis for privacy protections by appealing to all citizens who live under democratic regimes. …”

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Importantly, results obtained in SCA14 iPSCs faithfully recapitulated the pathological findings observed in the patient post-mortem cerebellum. …”

Integrating alternative and complementary medicine in the management of epilepsy and its comorbidities in low- and middle-income settings by Kariuki, SM, Newton, CRJC

“…There are however serious concerns on reliability of reported findings because of inadequate randomization, and small sample sizes, and concerns on quality and safety owing to lack of standardization of bioactive compounds, accidental or intention botanical substitution of products and unhygienic handling. …”

HSV-1 amplicon system for human artificial chromosome formation in human ES/iPS cells and pluripotency induction by Khoja, S

“…The HAC system, therefore, needs further refinements to improve the frequency of HAC formation and reduce the chromosomal integration of HAC constructs in hiPS cells. Overall, these findings provide a simple and safe way of pluripotency induction and genetic modification of pluripotent stem cells using the HSV-1 amplicon system and represent an important advance towards patient specific gene and cell therapy.…”

Health impact and economic evaluation of expanded program on immunization in China from 1974 to 2024: a modelling study by Wang, C, Lai, X, Abbas, K, Pouwels, KB, Zhang, H, Jit, M, Fang. H

“…Health and economic outcomes were determined using mathematical models between a counterfactual scenario without vaccination and the current vaccination scenario, based on both calendar year and birth cohort approaches. <p><strong> Findings: </strong></p> We estimated that China’s EPI averted 703.02 million cases (95% credible interval: 699.51-722.80) and 2.48 million deaths (2.14-2.97) in 1974-2024 based on the calendar year approach, equivalent to a reduction of 160.22 million DALYs (145.05-196.99). …”

Does negative parenting behavior lead to later peer victimization? A longitudinal co-twin control study by Oncioiu, S-I, Korde, A, Klatzka, C, Bowes, L

“…In exploratory analyses, we found that in early adolescence, monozygotic girls exposed to negative parenting behavior presented higher levels of peer victimization than boys (monozygotic girls: Beta = 0.11, 95% CI = 0.03–0.19; monozygotic boys: Beta = -0.08, 95%CI = -0.19, 0.02). Our findings suggest that the relationship between negative parenting behavior and children’s risk for peer victimization may reflect shared underlying environmental and genetic risks. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Fernandez, LG, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, SR, Patil, KD, Gairola, S, Dunachie, S, Merchant, HA, Stokes, R, Kuwana, R, Maes, A, Charrier, J, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, PN, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model by Emmerson, JT, Do Carmo, S, Lavagna, A, Huang, C, Wong, TP, Martinez-Trujillo, JC, Cuello, AC

“…As anticipated, at more advanced stages, the APPxhTau bigenic rats exhibited aggravated tau and amyloid pathologies, cognitive decline, increased neuroinflammation, and tau-driven neuronal loss compared to monogenic rat models of Alzheimer’s-like amyloid and tau pathologies. The present findings propose that the early accumulation of phosphorylated tau may have a transient protective impact on the evolving amyloid pathology-derived synaptic impairments.…”

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…Conclusion: Maternal night shift work during pregnancy was associated with newborn DNA methylation at 3 CpGs. Top findings overlapped with those in a mouse model of gestational jet lag. …”

Molecular mechanisms relevant to the maintenance of locomotor control by Guo, F

“…Excitingly, this significantly rescued the hyperlocomotor phenotype of the <em>Trkb</em>^PENK-KO mice. These findings add knowledge to the molecular mechanisms underlying normal locomotor maintenance, and they also highlight related pathway as a potential target for the development of novel treatments to movement disorders.…”

Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study by Arnold, JR, Yeo, JL, Budgeon, CA, Shergill, S, England, R, Shiwani, H, Artico, J, Moon, JC, Gorecka, M, Roditi, G, Morrow, A, Mangion, K, Shanmuganathan, M, Miller, CA, Chiribiri, A, Alzahir, M, Ramirez, S, Lin, A, Swoboda, PP, McDiarmid, AK, Sykes, R, Singh, T, Bucciarelli-Ducci, C, Dawson, D

“…Myocardial ischaemia was present in ~ 20% of patients recently hospitalised with COVID-19 and with elevated cardiac troponin, but this was not different to matched comorbid controls. This finding coupled with the lack of an association between ischaemia and myocardial scar suggests that coronary artery abnormalities are unlikely to be the predominant mechanism underlying COVID-19 induced myocardial injury. …”

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…<p><b>Conclusions</b></p> Plasma choline, as opposed to TMAO, was found to be associated with cognitive decline, brain atrophy, and markers of cerebral small vessel disease. These findings illustrate the complexity of relationships between TMAO and its precursors, and emphasize the need for concurrent study to elucidate gut-brain mechanisms.…”

Effectiveness and safety of COVID-19 vaccination in people with blood cancer by Copland, E, Hirst, J, Mi, E, Patone, M, Chen, D, Coupland, C, Hippisley-Cox, J

“…</p> <br> <p><strong>Findings:</strong> The cohort comprised 12,274,948 individuals, of whom 81,793 had blood cancer. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps, an... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, K

“…However, the majority of the present findings are based on linear cascade or low-speed rotational studies, due to the high cost of the experiments and difficulty in instrumentation at engine conditions. …”