An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Results: Using quantitative analysis, we found significantly lower levels of DNA methylation in the UGT1A1 locus in the anosmia group compared to the normosmia group, with a 14% decrease in median methylation values in patients with smell loss (p < 0.0001). These findings highlight potential epigenomic alterations in the UGT1A1 gene that may contribute to the pathogenesis of anosmia following COVID-19 infection. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…</p> <p>Together, these findings underscore the importance of T cell immunity in sustaining protection against SARS-CoV-2 variants. …”

Halving premature death and improving quality of life at all ages by Norheim, OF, Chang, A, Bolongaita, S, Barraza-Lloréns, M, Jha, P, Lewington, S, Jamison, DT, Peto, R

“…</p> <br> <p><strong>Findings:</strong> Globally, PPD decreased from 56% in 1970 to 31% in 2019, although some countries saw reversals because of conflict, social instability, or HIV and AIDS. …”

Prognostic significance of pleural fluid microbiological positivity in pleural infection: a bicentric 10-year retrospective observational study by Wong, C, Fan, HC, Rahman, NM, Wong, JCC, Cheng, HS, Chiu, PH, Tong, CW, Miu, FPL, Yam, LYC

“…Conclusions: Pleural fluid microbiological positivity is independently associated with increased mortality in patients with pleural infections. This finding should complement the RAPID score in risk stratification and inform future research aimed at improving outcomes in this patient population.…”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…</p> <br> <p><strong>Discussion:</strong> These findings indicate an epitope-specific pathophysiology of LGI1 autoantibodies. …”

Human agency and instrumental rationality: applying human capital to gender inequalities and intergenerational stratification by Luo, H

“…</p></br> <p><strong>Main Findings</strong></p> <p>Human Capital Transfer Between Spouses: Within marital relationships, a transfer of human capital exists. …”

Characterisation of collagen type I/ type II composite scaffolds for osteochondral tissue engineering by Tamaddon, M

“…The addition of chondroitin sulphate and fibrillogenesis increased the rigidity of the collagen chains and the viscosity of suspensions, thereby affecting the pore structure of the final scaffolds. A very important finding was that stem cells produced mostly collagen type II matrix molecules on these scaffolds, which differed from the production of collagen type I on type I scaffolds.…”

Improving antibiotic utilization in West Africa: enhancing interventions through systematic review and evidence synthesis by Donkor, ES, Osman, A, Aglomasa, BC, Awere-Duodu, A, Odoom, A, Opoku-Asare, B, Lazarus, G

“…Conclusion: This review identified gaps in knowledge and highlighted areas where prompt actions are required, it further guides future research endeavors and policy development. The findings underscore the need for further implementation of AMS programs across the West African region to enhance understanding of antibiotic use patterns, prescribing practices, and the factors influencing them in the region.…”

Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial by Yoshinaga, N, Thew, G, Hayashi, Y, Tanoue, H, Nakai, M, Clark, DM

“…An internet-delivered version of this treatment protocol (iCT-SAD) has recently been developed in the UK as a way to overcome this challenge, demonstrating comparable outcomes to face-to-face CT-SAD whilst requiring less therapist time per client. Initial findings also suggest its cross-cultural transferability, but the previous studies in other cultural settings used the English language programme and only included English-fluent participants as a second language. …”

Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

“…I carried out validation and mechanistic studies that confirmed that loss of TMED2 and TMED10 results in nuclear FoxO1-Clover retention following insulin treatment, as well as aberrant AKT phosphorylation. These findings confirmed that TMED2 and TMED10 are novel regulators of hepatic insulin signalling.…”

The molecular determinants of Polycomb-mediated gene repression by Fursova, N

“…In conclusion, through systematic dissection of the Polycomb system, I have provided compelling evidence for a variant PRC1-dependent logic for formation of Polycomb chromatin domains and repression of Polycomb target genes. Together, my findings place PRC1 and its catalytic activity at the forefront of Polycomb-mediated transcriptional silencing, paving the way for a mechanistic understanding of Polycomb system function.…”

Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…</p> <p>My studies and thesis underscore the potential of NTX as a viable alternative for bacterial infection prevention/treatment in poultry farming. The findings contribute to the development and prudent use of NTX in farm animal production, offering a promising solution to the challenge of AMR in agriculture.…”

Evaluating the impact, implementation experience and political economy of primary care networks in Kenya: protocol for a mixed methods study by Amboko, B, Nzinga, J, Tsofa, B, Mugo, P, Musiega, A, Maritim, B, Wong, E, Mazzilli, C, Ng’ang’a, W, Hagedorn, B, Turner, G, Musuva, A, Murira, F, Ravishankar, N, Hussein, S, Barasa, E

“…The two strands will be mixed during data collection to refine questions, with findings triangulated during analysis and interpretation to provide a comprehensive understanding of PCN implementation. …”

Childlessness and its associated factors among Chinese women: a nationwide population-based study by Han, Q, Dang, J, Wu, Y, Ye, W

“…Conclusions: This study used the most recent nationwide survey data from China to identify factors associated with childlessness and reproductive anxiety, with an emphasis on socio-economic factors and domestic violence. The findings highlight the significant impact of domestic violence on fertility behaviors and reproductive anxiety, providing valuable evidence for future policy interventions.…”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…We classified pairs of conditions as across or within-domain based on the international classification of disease.</p> <p><strong>Findings: </strong>We identified 72 chronic conditions, with 43.6% of 2546 pairs showing higher co-occurrence than chance in primary care and evidence of shared genetics. …”

Managing risks to the media from emerging networked technologies by Shere, ARK

“…</p> <p>This research includes the findings from an exploratory study to scope the novelty of focusing on journalists as a specific population threatened by the IoT. …”

Programs to Address Violence for Military Families: a Systematic Review by Dodge, J, Wortham, W, Kale, C, Williamson, V, Ross, A, Maher, S, Kononowech, J, Winters, J, Sullivan, K

“…Conclusion: This study had three main findings: (1) The majority of interventions were for Veterans and/or their partners rather than active service personnel; (2) All interventions reported positive outcomes in the reduction of self-reported IPV, with the majority of these outcomes maintained over time; (3) While we intended to assess military family-level interventions that targeted IPV and CM, we only found three studies that targeted or included CM. …”

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…</p> <p><strong>Conclusions:&nbsp;</strong>Our findings reveal a mechanism by which blocking IP6K1 boosts apoA-I production. …”

Acute seizure risk in patients with encephalitis: development and validation of clinical prediction models from two independent prospective multicentre cohorts by Wood, GK, Babar, R, Ellul, MA, Thomas, RH, Van Den Tooren, H, Easton, A, Tharmaratnam, K, Burnside, G, Alam, AM, Castell, H, Boardman, S, Collie, C, Facer, B, Dunai, C, Defres, S, Granerod, J, Brown, DWG, Vincent, A, Marson, AG, Irani, SR, Solomon, T, Michael, BD

“…<p><strong> Conclusion </strong></p>Age, GCS, fever and aetiology can effectively stratify acute seizure risk in patients with encephalitis. These findings can support the development of targeted interventions and aid clinical trial design for antiseizure medication prophylaxis.…”

Fictions of youth: childness in selected West African novels, 1991-2009 by Moellenberg, T

“…</p> <p>Chapter 3 continues to explore the figure of the child as a complex and multivalent symbol. However, it finds that Helen Oyeyemi's <em>The Icarus Girl</em> (2005) and Yaba Badoe's <em>True Murder</em> (2009) do not disavow children's personhood, as Iweala and Jarrett-Macauley appear to do. …”