The sustainable use of species-rich grasslands for forage and biogas production by French, K

“…Finally, by combining palaeoecological and modern vegetation data I demonstrate that grassland biodiversity was temporally and spatially linked to long-term human management and would revert to oscillating between open grassland and woodland if this management ceases. …”

Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…<p>Patients with rapid eye movement sleep behaviour disorder (RBD) have a high long-term risk of developing Parkinson’s disease or a related synucleinopathy. …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…<br><strong> Summary<br></strong> The genus Rafflesia, which includes the world's largest flowers, has aroused curiosity among scientists for centuries and features prominently in local culture across Southeast Asia. The plant has long been used in ethnobotanical medicine and, more recently, as a source of revenue from ecotourism. …”

Modelling frequency-based neural responses to deep brain stimulation in Parkinson’s disease by Sermon, JJ

“…In Chapter 4, we create a network model that can reproduce long-term dynamic frequency responses to DBS. We suggest that single neuronal populations may be able to replicate these observations and that vesicle depletion may be a fundamental neural response to DBS. …”

Essays on the market for corporate bonds by Levonmaa, A

“…Drawing on similar studies of other markets, the relationship between returns and order flow is modelled using a vector autoregression, and the information content of a trade is measured as the long-run price impact of a shock to order flow. Price impacts are particularly strong and significant for order flow from institutional investors and for bonds with higher default risk, higher volatility and lower liquidity. …”

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Notably, the dendritic development and survival of human SCA14 Purkinje cells were significantly compromised in long-term culture. CRISPR/Cas9-mediated genome editing was also employed to correct the mutations and produce isogenic controls of SCA14 iPSCs. …”

Dental resin monomer enables unique NbO2/carbon lithium-ion battery negative electrode with exceptional performance by Ji, Q, Gao, X, Zhang, Q, Jin, L, Wang, D, Xia, Y, Yin, S, Xia, S, Hohn, N, Zuo, X, Wang, X, Xie, S, Xu, Z, Ma, L, Chen, L, Chen, G, Zhu, J, Hu, B, Müller-Buschbaum, P, Bruce, PG, Cheng, L

“…The results suggest that the NbO2/carbon nanohybrid bearing high capacity, long cycle life and low gas-evolution is promising for lithium storage applications.…”

HSV-1 amplicon system for human artificial chromosome formation in human ES/iPS cells and pluripotency induction by Khoja, S

“…HAC offers many potential advantages including the provision for carrying large genes with corresponding regulatory elements to obtain long-term regulated gene expression. In addition, they can replicate and segregate independently without integration into the host cell genome. …”

Investigating the impact of ligand modification on luminescent lanthanide complexes by Simms, CH

“…This reduction for Gd(III) complexes resulted in a change in realxivity, and for Tb(III) complexes, an impressive turn on of long lived bright green emission.</p> <p><strong>Chapter 4</strong> investigates the structure and speciation of common heptadentate lanthanide complexes in solution. …”

Mine yOur owN Anatomy: revisiting medical image segmentation with extremely limited labels by You, C, Dai, W, Liu, F, Min, Y, Dvornek, NC, Li, X, Clifton, DA, Staib, L, Duncan, JS

“…However, they face three common pitfalls: (1) tailness: medical image data usually follows an implicit long-tail class distribution. Blindly leveraging all pixels in training hence can lead to the data imbalance issues, and cause deteriorated performance; (2) consistency: it remains unclear whether a segmentation model has learned meaningful and yet consistent anatomical features due to the intra-class variations between different anatomical features; and (3) diversity: the intra-slice correlations within the entire dataset have received significantly less attention. …”

Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Naemiratch, B, Kulpijit, N, Ruangkajorn, S, Day, NPJ, Prachumsri, J, Cheah, PY

“…Conclusions: Our study revealed widespread concerns about long-term health effects and safety. Ethical considerations, including obtaining valid informed consent and ensuring participant inclusivitiy, were deem essential. …”

An analysis of heavy silicone oil treatment for inferior proliferative vitreoretinopathy by Hammer, M, Ie, A, Eibenberger, K, Auffarth, GU, Xue, K

“…In 20% of cases, an increased medication was continued long-term after Densiron removal. Significant cataract progression occurred in all phakic patients. …”

Industrial policy refraction: how corporate strategy shapes development outcomes in Brazil by Zylberberg, E

“…</p> <p>Multinational firms based in industrialized countries have long been seen as sources of technology (Evans, 1979). …”

Development of Attention-based Prediction Models for All-cause Mortality, Home Care Need, and Nursing Home Admission in Ageing Adults in Spain Using Longitudinal Electronic Health... by Carrasco-Ribelles, LA, Cabrera-Bean, M, Khalid, S, Roso-Llorach, A, Violán, C

“…However, nursing home admission and home care need in the long term were harder to predict, suggesting their dependence on more abrupt changes. …”

Differences between neonatal units with high and low rates of breast milk feeding for very preterm babies at discharge: a qualitative study of staff experiences by McLeish, J, Aloysius, A, Gale, C, Quigley, M, Kurinczuk, JJ, Alderdice, F

“…Results: Five themes were developed: ‘The role of the infant feeding specialist’, ‘Achieving a whole team approach to breast milk feeding’, ‘Supporting initiation of breastfeeding’ ‘Supporting long-term expressing’, ‘Supporting the transition to breastfeeding’. …”

Nonlinear evolution and acceleration of unstable fuel-lean hydrogen/air flame at normal and cryogenic temperatures by Yang, L, Zhang, T, Wang, Y, Fang, X, Leach, F, Chen, Z

“…In contrast, for stoichiometric or fuel-rich flames without DTI, flames propagate in a steady single-cusp regime. Analyses show that long-term dynamics for fuel-lean flames including cell splitting, merging and lateral movement are caused by flow-flame-chemistry interaction. …”

Unfinished business: legalisation and implementation in business and human rights by Palmer, C

“…The empirical chapters demonstrate that efforts in implementation are often undertaken for the purpose of strengthening one or more other legalisation characteristics in the long run. This suggests that agents will be willing to accept lower levels of obligation, precision and/or delegation if they believe a focus on implementation will help strengthen these characteristics over time.…”

Interventions for prevention and treatment of trastuzumab-induced cardiotoxicity: an umbrella review of systematic reviews and meta-analyses by Wang, Y, Xu, J, Xie, Y, Zhou, D, Guo, M, Qin, Y, Yi, K, Tian, J, You, T

“…Further research should focus on optimizing personalized approaches and evaluating long-term outcomes.…”

Temporal evolution of mechanical properties in PDMS: A comparative study of elastic modulus and relaxation time for storage in air and aqueous environment by Zhang, Y, Adam, C, Rehnstrom, H, Contera, S

“…These variations in mechanical properties could significantly influence the long-term functionality of PDMS in various biomedical applications.…”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…One of defining features of the cells of the nervous system is their strong polarity. They have long projections that extend to distances that could be thousands of times the length of the cell body. …”