The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…</p> <p><strong>Methods and analysis:</strong> Patients with newly diagnosed PsA and at least one poor prognostic factor (polyarthritis, C-reactive protein >5 mg/dL, health assessment questionnaire >1, radiographic erosions) were randomized equally and open-label to either standard care with ‘step-up’ csDMARD therapy, initial therapy with combination csDMARDs (methotrexate with either sulfasalazine or leflunomide) or to early biologics induction therapy (adalimumab plus methotrexate). …”

Developing small molecule ligands for the study of bromodomain-histone interactions by Brand, M

“…</p> <p>A second project in this dissertation reports the development of a small, modular photo affinity based probe based on a 3,5-dimethylisoxazole acetyl lysine mimic. This probe could be crosslinked to purified bromodomain proteins with up to 30% efficiency and subsequently modified <em>via</em> CuAAc chemistry to attach a fluorophore or biotin tag. …”

Self-supervised machine learning to characterise step counts from wrist-worn accelerometers in the UK Biobank by Small, SR, Chan, S, Walmsley, R, von Fritsch, L, Acquah, A, Mertes, G, Feakins, BG, Creagh, A, Strange, A, Matthews, CE, Clifton, DA, Price, AJ, Khalid, S, Bennett, D, Doherty, A

“…</p> <br> <p><strong>Results:</strong> The algorithm substantially outperformed reference models (free-living mean absolute percent error of 12.5%, versus 65-231%). Our data indicate an inverse dose-response association, where taking 6,430-8,277 daily steps was associated with 37% [25-48%] and 28% [20-35%] lower risk of fatal CVD and all-cause mortality up to seven years later, compared to those taking fewer steps each day.…”

Dharmakīrti versus Akalaṅka on the nature, object, and structure of perception by Nahata, S

“…While chapters 1 and 2 introduce Dharmakīrti’s theory of perception and Akalaṅka’s theory of perception respectively, each of the subsequent chapters (chapters 3, 4, 5) examines a particular point of contention by (a) explaining the philosophical issue at stake, (b) reconstructing and analysing the arguments advanced by both sides for their respective positions, and (c) reflecting on the significance of the debate. …”

Oikeion, Agathon, and Archaia Phusis in Plato’s Symposium by Crüwell, HS

“…While a reading that posits a rejection of immortality in the Symposium must indeed deny a role for the concept in Diotima’s speech, I show that a reading allowing for immortality as a theoretical commitment in the background has an interesting interpretative option: along with Timaeus 90d5, it may fruitfully interpret the ascent as an ordering of the soul ‘in accordance with its archaia phusis’.…”

Multicenter double-blind study evaluating AI-driven detection of proximal deep vein thrombosis by Curry, N, Allen, E, Silsby, L, Goodacre, S, Deane, C, Deary, A, Foster, A, Griffiths, J, Sharma, R, Thomas, H, Mischewitz, S, Al-Noor, F

“…Proximal DVT was detected in 10.5% of those analyzed. AutoDVT resulted in 68% sensitivity (95% confidence interval [CI], 49 to 83%) and 80% specificity (95% CI, 74 to 85%) for the detection of proximal DVT. …”

Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…Surprisingly, the complete cleavage of tetra-ubiquitin-modified H1, but not the 2xISG15-H1 fusion, can be observed within 5 min by the SprT core, indicating the much more efficient activating effect of Ub chains on SPRTN proteolysis.…”

The interaction between ketone bodies and carbohydrate in human metabolism by Holdsworth, D

“…There was an increase in glucose disposal during euglycaemic (5 mM glucose) clamping in healthy controls, but no difference in T2DM patients. …”

Controls on present-day and future rainfall over southern Africa in coupled climate models by Munday, C

“…In models projecting the highest magnitude drying, the northern tropical oceans warm at a faster rate than the tropical mean (+0.5 K), and this is associated with enhanced subsidence and greater atmospheric stability over southern Africa. …”

Place-based household vouchers for locally supplied fruit and vegetables: the Fresh Street pilot cluster randomised controlled trial by Relton, C, Blake, MK, Bridge, G, Umney, D, Taylor, SJC, Adams, J, Mihaylova, B, Griffiths, C, Hooper, R, Phillips, R, Palmer, L, Gamston, A, Williamson, K

“…Weekly envelopes containing vouchers (5 x £1), a healthy seasonal recipe and brief nutritional information were offered to all households in nine intervention streets. …”

A multi-omics strategy to understand PASC through the RECOVER cohorts: a paradigm for a systems biology approach to the study of chronic conditions by Sun, J, Aikawa, M, Ashktorab, H, Beckmann, ND, Enger, ML, Espinosa, JM, Gai, X, Horne, BD, Keim, P, Lasky-Su, J, Letts, R, Maier, CL, Mandal, M, Nichols, L, Roan, NR, Russell, MW, Rutter, J, Saade, GR, Sharma, K, Shiau, S, Thibodeau, SN, Yang, S, Miele, L, NIH Researching COVID to Enhance Recovery (RECOVER) Consortium

“…Post-Acute Sequelae of SARS-CoV-2 infection (PASC or “Long COVID”), includes numerous chronic conditions associated with widespread morbidity and rising healthcare costs. …”

The molecular pathogenesis of FUS mutations in amyotrophic lateral sclerosis using in vivo and in vitro models by Kent, L

“…Most ALS occurs in a sporadic manner, though 5-10% is familial. Fused in sarcoma (FUS) is an RNA binding protein, and mutations in the FUS gene are responsible for approximately 4% of familial and &amp;LT;1% of sporadic ALS cases. …”

Taburan menegak mikroplastik dalam sedimen teras di Muara Sungai Pulai, Johor by Laila Zulaifah Zulkipli, Nurul Aisyah Mohd Zaki, Mohamad Hafiz Abdul Halim, Khairiatul Mardiana Jansar, Mohd Talib Latif, Masni Mohd Ali

“…Hasil daripada kajian ini menunjukkan kelimpahan mikroplastik yang paling tinggi didapati pada lapisan sedimen teratas (0–5 cm) iaitu 506 ± 115.47 partikel/kg di stesen SP1 dan sebanyak 220.00 ± 28.28 partikel/kg pada lapisan pertengahan (10–15 cm) di stesen SP2. …”
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Exploring enhanced syngas production via the catalytic performance of metal-doped X-Ni/CeO2 (X = Zr, La, Sr) in the dry reforming of methane by Manan, Wan Nabilah, Wan Isahak, Wan Nor Roslam, Yaakob, Zahira, Samidin, Salma, Ahmad, Khairul Naim, Latif, Mohd Nor, Aldoghachi, Ali Faris, Taufiq-Yap, Yun Hin

“…The integration of promoters in DRM catalysts has notably improved carbon formation resistance, as evidenced by the following ranking: Zr/NiCeO2 (5.1 wt%) < commercial catalyst (6.0 wt%) < La/NiCeO2 (7.85 wt%) < Sr/NiCeO2 (10.9 wt%) < NiCeO2 (11.3 wt%). …”

Microplastics in urban soils from different land use activities of Cyberjaya (Malaysia): exploring occurrence, relationships, sources and pollution level by Praveena, Sarva Mangala, Nik Mohd Zaidi, Nik Munirah, Nafisyah, Ayu Lana, Lingaraju, H.G.

“…Microplastics occurrence ranged from 0.3 to 1.5 particle/kg, with the highest average occurrence in the construction area (0.69 particle/kg) and lowest in the vacant area (0.33 particle/kg). …”
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Evaluation of high school-based dengue solution model in Southern Thailand: a community participatory action research by Suwanbamrung, Charuai, Mehraj, Sandeep Kumar, Kercho, Melkamu Worku, Stanikzai, Muhammad Haroon, Ageru, Temesgen Anjulo, Jaroenpool, Jiraporn, Pibul, Panatda, Shohaimi, Shamarina, Israel, Eskinder

“…Results: Two hundred and thirty-nine (96.3%, n = 239/248) and 232 (93.5, n = 232/248) participants were included in the interventions before and after, respectively. …”
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Nutritional assessment of rural villages and estates in peninsular Malaysia: total blood cholesterol values in children, adolescents and adults by Wai, Tony Ng Kock, Lin, Khor Geok, Siong, Tee E., Hashim, Normah

“…Mean TC levels for children and adolescents were in the range 3.85-4.37 mmol/L, rising markedly during adulthood to an overall mean of 4.91 ± 1.13 mmol/L for men and 5.17 ± 1.11 mmol/L for women. In adults (≥ 18.0 years), there was marked disparity in mean TC values among the functional groups; males and females from rice households had the lowest mean TC values (4.58 and 4.99 mmol/L, respectively). …”

Implementation of lean manufacturing practices and six-sigma among Malaysian manufacturing SMEs: intention to implement IR 4.0 technologies by Ibikunle, Afeez Kayode, Rajemi, Mohamad Farizal, Mohd Zahari, Fadhilah

“…Nevertheless, lean and 6s has an influence on sustainable performance among Malaysian manufacturing SMEs. Only about 32.5% Malaysian manufacturing SMEs have the intention to implement IR 4.0 technologies. …”
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Location Selection for Beekeeping in Optimizing Honey Production using Linear Programming Model (S/O 14038) by Abdul Rahman, Syariza, Benjamin, Aida Mauziah, Omar, Mohd Faizal

“…The criteria are (1) flowers and plants, (2) water and hydrology, (3) land features, (4) apiary, (5) human activities, (6) pest, (7) wind and humidity, (8) road network, and (9) temperature. …”
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Human Work Interaction Design : A Platform for Theory and Action / by Clemmensen, Torkil, author 275679