The mammalian EMC in membrane protein biogenesis by Volkmar, N

“…Sensitivity to cholesterol loss in EMC6 knockout cells was reproduced by direct deletion or pharmacological inhibition of SQS. mEMC depletion also caused imbalances in the mevalonate pathway, likely leading to increased shunting of the farnesyl pyrophosphate precursor into the isoprenoid pathway, increasing the detection of prenylated proteins. …”

'The burglar's mate'? How London's probation officers persuaded magistrates in Social Enquiry Reports, 1958-72 by Lunan, J

“…The university graduates therefore invoked normative character ideals in SERs because they believed it was likely to be the best way to achieve the desired outcome in court. …”

The responsible innovation of disruptive technologies by Inglesant, P, Webb, H, Ten Holter, C, Patel, M, Jirotka, M

“…Without effective intervention the response to these challenges is likely to be driven by economic interests. However, through RI, alternative futures are also possible. …”

Reconstructing prehistoric lifeways using multi-Isotope analyses of human enamel, dentine, and bone from Legaire Sur, Spain by Griffith, JI, James, HF, Ordoño, J, Fernández-Crespo, T, Gerritzen, CT, Cheung, C, Spros, R, Claeys, P, Goderis, S, Veselka, B, Snoeck, C

“…Oxygen and strontium isotope analysis suggest all individuals come from a similar, likely local, geological region, aside from one biological female who presents a notably different geographical birthplace, weaning, and dietary life history than the rest of the burial population. …”

Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Ferla, MP, Sánchez-García, R, Skyner, RE, Gahbauer, S, Taylor, JC, von Delft, F, Marsden, BD, Deane, CM

“…This method has had a prior real-world application in hit-to-lead screening, yielding a sub-micromolar merger from parent hits in a single round. It is therefore likely to further benefit future drug design campaigns and be integrated in future pipelines. …”

Highly variable freshwater reservoir offsets found along the Upper Lena watershed, Cis-Baikal, southeast Siberia by Schulting, R, Ramsey, CB, Bazaliiskii, VI, Weber, A

“…While the river flows over carbonate bedrock and is moderately alkaline, we suggest that old terrestrial carbon entering the riverine foodweb through bank erosion and other processes is a more likely candidate for the majority of the ¹⁴C offset.…”

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…We summarize the essential principles and utility of large simple RCTs, likely applicable to all interventions but especially in order to promote their wider adoption to evaluate new medical devices.…”

Systematic assessment of COVID-19 host genetics using whole genome sequencing data by Schmidt, A, Casadei, N, Brand, F, Demidov, G, Vojgani, E, Abolhassani, A, Aldisi, R, Butler-Laporte, G, DeCOI host genetics group, Alawathurage, TM, Augustin, M, Bals, R, Bellinghausen, C, Berger, MM, Bitzer, M, Bode, C, Boos, J, Brenner, T, Cornely, OA, Eggermann, T, Erber, J, Feldt, T, Fuchsberger, C, Gagneur, J

“…We observed the presence of autosomal-recessive or likely compound heterozygous monogenic disorders in six individuals, all of which were hospitalized and significantly younger than the rest of the cohort. …”

Experimental heatwaves facilitate invasion and alter species interactions and composition in a tropical host‐parasitoid community by Chen, J, Lewis, O

“…The interactive effects of climate change and climate change-facilitated invasion have rarely been studied in multi-trophic communities, and are likely to differ depending on the nature of the climatic driver (i.e., climate extremes or constant warming). …”

Asymptomatic female softball pitchers have altered hip morphology and cartilage composition by Warden, SJ, Coburn, SL, Fuchs, RK, Surowiec, RK, Carballido-Gamio, J, Kemp, JL, Jalaie, PK, Hanff, DF, Palmer, AJR, Fernquest, SJ, Crossley, KM, Heerey, JJ

“…Pitch1 had 52% greater maximum alpha angle than Run (p < 0.001) and were 21.3 (95% CI 2.4 to 192.0) times more likely to have an alpha angle ≥ 60° within at least one hip. …”

Heightened interoception in adults with fibromyalgia by Todd, J, Plans, D, Lee, M, Bird, J, Morelli, D, Cunningham, A, ponzo, S, Murphy, J, Bird, G, Aspell, J

“…The FMS sample were more likely to be classified as ‘interoceptive’ on the PAT, and had significantly higher self-reported interoception compared to the pain-free sample. …”

Sleep and circadian difficulties in schizophrenia: presentations, understanding, and treatment by Freeman, D, Waite, F

“…Treatment is also very likely to lessen psychotic experiences and mood disturbances, while improving daytime functioning and quality of life. …”

Rediscovering Homo sapiens in international politics: evolution and rationality’s missing link by Johnson, D

“…An evolutionary perspective suggests: (1) rational choice is not always the most effective or efficient solution to decision-making problems; (2) cognitive biases are not mistakes, but adaptive “strategic instincts,” which evolved because they helped us make good decisions, not bad ones; (3) these “non-rational” dispositions follow a systematic pattern, allowing predictions about how people are likely to react under given conditions; (4) a theory for the origins of preferences; (5) an explanation for why humans can sometimes seem rational and sometimes non-rational (because adaptive behavior depends on context); and finally (6) error management theory suggests that cognitive biases evolved precisely because of uncertainty, as a way of minimizing costs over time. …”

Implications of human-nature interactions for livelihoods and conservation in Kasungu, Malawi by Mandoloma, L, Clark, M, Hughes, K, Coad, L, Milner-Gulland, E

“…Households near the park, women, and those of lower economic status were more likely to rely on the park for resources. Additionally, crop and livestock loss experiences were linked to higher resource collection rates. …”

Principal competency, teacher readiness, and teacher commitment in STEM education implementation: a qualitative study by Sariati Talib, Bity Salwana Alias, Mohd Effendi @ Ewan Mohd Matore

“…Findings reveal that principals with competencies in STEM knowledge, management skills, and professional attributes are more likely to boost teacher readiness and commitment. …”
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Journey into genetics: taking the twists and turns of life by Rosli, Rozita

“…Subsequently, the selected research projects that were carried out in the application of genetics and genetic technologies in cancer, especially breast cancer, infectious diseases and therapeutics, including genetic immunisation will be chronicled and highlighted. It is highly likely that human genetics research through the years will become an increasingly more integral component of medical research. …”
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Proposed Design for Electromechanical Telescoping Actuator to Replace Hydraulics in Extreme High Force and Long Stroke Applications by Sleight Crawford, Carmen, Smyk, Mariia, Cheung, Sophia, Coughran, Doug, Costello, Jeffrey, Liang, ZhiYi, Winter, Amos G

“…Our group was able to successfully develop and evaluate the design and build a scaled-down prototype that could likely serve as a direct replacement for currently used long-stroke high-force hydraulics. …”
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Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…In cultured neurons, KO of VPS50 did not affect the number of synaptic vesicles but did cause mislocalization of the V-ATPase V1 domain pump and impaired synaptic activity, likely as a consequence of defects in vesicle acidification and vesicle content. …”
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Inferring electrospray emission characteristics from molecular dynamics and simulated retarding potential analysis by Schroeder, Madeleine, Gallud, Ximo, Petro, Elaine, Jia-Richards, Oliver, Lozano, Paulo C

“…We find that for these experimental data, temperatures of EMI-BF4 dimers likely range between 590 and 687 K while trimer temperatures are larger between 989 and 1092 K. …”
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Defects in β-cell Ca2+ dynamics in age-induced diabetes by Li, Luosheng, Trifunovic, Aleksandra, Köhler, Martin, Wang, Yixin, Petrovic Berglund, Jelena, Illies, Christopher, Juntti-Berggren, Lisa, Larsson, Nils-Göran, Berggren, Per-Olof

“…We show that these changes are likely to be accounted for by impaired mitochondrial function and to involve phospholipase C/inositol 1,4,5-trisphosphate–mediated Ca2+ mobilization from intracellular stores as well as decreased β-cell Ca2+ influx over the plasma membrane. …”
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