Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells by Mariati, Yeo, Jessna H. M., Koh, Esther Y. C., Ho, Steven C. L., Yang, Yuansheng

“…The human cytomegalovirus promoter (hCMV) is susceptible to gene silencing in CHO cells, most likely due to epigenetic events, such as DNA methylation and histone modifications. …”
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A 15-year review of dengue hospitalizations in Singapore : reducing admissions without adverse consequences, 2003 to 2017 by Ang, Li Wei, Thein, Tun-Linn, Ng, Yixiang, Boudville, Irving Charles, Chia, Po Ying, Lee, Vernon Jian Ming, Leo, Yee-Sin

“…Further studies are needed to optimize dengue management in older adults who are more likely to be hospitalized with greater disease severity, given the higher proportions of hospitalizations and severe disease among older adults.…”
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Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility by Kurochkin, Igor V., Alkuraya, Fowzan S., Iwasa, Hiroyasu, Akita, Masumi, Tsukui, Tohru, Ito, Chizuru, Shimozawa, Nobuyuki, Iseki, Mioko, Mizuno, Yumi, Ninomiya, Yuichi, Nakachi, Yutaka, Toshimori, Kiyotaka, Nishimukai, Megumi, Hara, Hiroshi, Maeba, Ryouta, Okazaki, Tomoki, Alodaib, Ali Nasser Ali, Amoudi, Mohammed Al, Jacob, Minnie, Horai, Yasushi, Watanabe, Mitsuhiro, Motegi, Hiromi, Wakana, Shigeharu, Noda, Tetsuo, Mizuno, Yosuke, Schönbach, Christian, Okazaki, Yasushi

“…These phenotypic features are most likely the result of changes in the molecular species composition of choline and ethanolamine plasmalogens. …”
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Creativity in Intelligent Technologies and Data Science : 4th International Conference, CIT&DS 2021, Volgograd, Russia, September 20-23, 2021 : Proceedings / by CIT&DS (Conference) (4th : 2021 : Volgograd, Russia), organiser 642924, Kravets, Alla G., editor 642925, Shcherbakov, Maxim, editor 642926, Parygin, Danila, editor 642927, Groumpos, Peter P., editor 642928

Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…Additionally, HMMScan indicates the particular lots most likely to be related to risky states of the manufacturing or supply chain condition. …”
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Facilitating gamified lower-extremity rehabilitation through novel VR MI-BCI system by Pramotedham, Chavalit

“…Additionally, while the difference in BCI performance in VR vs. 2D was not deemed to be statistically significant (p = 0.38), this is likely due to the extremely small sample size (n = 12) within this preliminary study. …”
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3D confined jet scour at a wall by Chee, Wei Hong

“…Beyond the jet outlet location, the scoured sediment bed was observed to be uneven likely due to the recirculating flow affected by the ridges formed. …”
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Island area and remoteness shape plant and soil bacterial diversity through land use and biological invasion by Xu, Mingshan, Yang, Anna, Yang, Xiaodong, Cao, Wenting, Zhang, Zengke, Li, Zengyan, Zhang, Yu, Zhang, Huaguo, You, Wenhui, Yan, En-Rong, Wardle, David A.

“…Soil bacterial diversity was directly negatively impacted by island remoteness, and indirectly negatively impacted by island remoteness through increased soil electrical conductivity likely caused by greater salinity from sea spray. …”
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Three essays on corporate finance by Sun, Rui

“…Special features of private firms – more concentrated equity ownership, more powerful shareholders with a strong desire for liquidity and diversification, and higher agency costs associated with debt finance are very likely to play a vital role in shaping their cash flow allocation. …”
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Rapid and punctuated Late Holocene recession of Siling Co, central Tibet by Shi, Xuhua, Kirby, Eric, Furlong, Kevin P., Meng, Kai, Robinson, Ruth, Lu, Haijian, Wang, Erchie

“…Mapping and surveying of lacustrine shorelines coupled with optically stimulated luminescence dating of associated deposits indicate protracted occupation of a highstand elevation from >8 ka to 4 ka, followed by rapid recession that was likely punctuated by several stillstands of centennial-scale duration. …”
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Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications by Nguyen, Son Truong, Nguyen, Hoa Tien, Rinaldi, Ali, Nguyen, Nam P. V., Fan, Zeng, Duong, Hai Minh

“…Of all the challenges facing human beings in the near future, energy related issues are likely to be the grandest. To achieve a more sustainable society with adequate renewable energy and less environmental pollution, more versatile, robust and efficient approaches in electric energy storage and conversion are needed. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…Notably, Omicron’s high mutation count challenges antibody responses, yet T cell responses remain comparatively maintained, likely mitigating severe outcomes during Omicron waves.…”

A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Females were under-represented and less likely to be eligible for the trials.</p> <br> <p><strong>Conclusion:</strong> SGLT2 inhibitor kidney outcome trials represent a subgroup of people with CKD at high risk of adverse kidney events. …”

The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…</p> <p>Calcium released from the lysosome in response to NAADP action at TPC2 is thought to modulate calcium release from the SR. This process is likely to require a close spatial relationship between these organelles. …”

Environmental risk factors for self-harm during imprisonment: a prospective cohort study by Stephenson, T, Harris, I, Armstrong, C, Fazel, S, Short, R, Blackwood, N

“…Findings regarding staff-prisoner ratio and self-harm most likely reflect a reverse causal relationship. Replication in larger cohort studies is required to address the limitations of this pilot study.…”

The impact of social isolation on delayed hospital discharges of older hip fracture patients and associated costs by Landeiro, F, Leal, J, Gray, A

“…Patients who were admitted from an institution were less likely to have delayed discharges (OR 0.2) with 5.5 fewer days of delay. …”

A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care data by Murrin, O, Mounier, N, Voller, B, Tata, L, Gallego-Moll, C, Roso-Llorach, A, Carrasco-Ribelles, LA, Fox, C, Allan, LM, Woodward, RM, Liang, X, Valderas, JM, Khalid, S, Dudbridge, F, Lamb, SE, Mancini, M, Farmer, L, Boddy, K, Bowden, J, Melzer, D, Frayling, TM, Masoli, JAH, Pilling, LC, Violán, C, Delgado, J

“…Discordance between genetic and primary care data was also observed, e.g., abdominal aortic aneurysm and bladder cancer co-occurred in primary care but were not genetically correlated (Odds-Ratio = 2.23 [2.09:2.37], 𝑅𝑔 = 0.04 [−0.20:0.28]) and schizophrenia and fibromyalgia were less likely to co-occur together in primary care but were positively genetically correlated (OR = 0.84 [0.75:0.94], 𝑅𝑔 = 0.20 [0.11:0.29]).…”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Assessment of novel pre-erythrocytic malaria vaccines in humans by Venkatraman, N

“…In addition to humoral immunity, it is widely recognised that T-cell mechanisms are likely to play an important role in malaria immunity and heterologous prime-boost regimes using viral-vectored vaccines have been shown to induce potent T-cell responses. …”

A mixed methods study investigating factors affecting adherence to Plasmodium vivax malaria primaquine radical cure regimens among migrants along the Myanmar-Thailand border by Ansari, AT, Aung, KK, Win, HH, Beau, C, Nu, B, Soe, NL, Htoo, K, San, T, Wah, TG, Keereevijit, A, Phyo, AP, Chotivanich, K, White, NJ, Nosten, F, Hashmi, AH, Chu, CS

“…Patients of Karen ethnicity (OR 1.7, 95% CI 1.2–2.3; p = 0.001) or having a previous episode of malaria from any species (OR 1.6, 95% CI 1.1–2.3; p = 0.007) were more likely to report completing the 14-day primaquine radical cure regimen. …”