Functional genetics of cancer and congenital disorders by Zak, J

“…In summary, this work identified novel candidate pathogenic variants in developmental disorders and cancer, and explored the mechanisms underlying their respective genotype-phenotype links.</p>…”

Barriers and opportunities for WHO ‘best buys’ non-communicable disease policy adoption and implementation from a political economy perspective: a complexity systematic review by Loffreda, G, Arakelyan, S, Bou-Orm, I, Holmer, H, Allen, LN, Witter, S, Ager, A, Diaconu, K

“…</p> <p><strong>Results:</strong> Our CLD highlights a central feedback loop encompassing three vital variables: (1) the ability to define, (re)shape, and pass appropriate policy into law; (2) the ability to implement the policy (linked to the enforceability of the policy and to addressing NCD local burden); and (3) ability to monitor progress, evaluate and correct the course. …”

Characterising the functional role of GATA1short isoform in normal and malignant haematopoiesis by Cruz Hernandez, D

“…Both TAM and ML-DS are driven by mutations in the gene encoding the X-linked erythroid-megakaryocyte transcription factor GATA1 that result in truncation of 83 N-terminal amino acids to produce GATA1short (GATA1s). …”

External validation of the QCovid risk prediction algorithm for risk of COVID-19 hospitalisation and mortality in adults: national validation cohort study in Scotland by Simpson, CR, Robertson, C, Kerr, S, Shi, T, Vasileiou, E, Moore, E, McCowan, C, Agrawal, U, Docherty, A, Mulholland, R, Murray, J, Ritchie, LD, McMenamin, J, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR (RT-PCR) virology testing, hospitalisation and mortality data. …”

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…Subsequently, we examined their link to structural brain MRI markers in 2,047 participants, with a partial validation in the Leiden Longevity Study (n = 318). …”

Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Naemiratch, B, Kulpijit, N, Ruangkajorn, S, Day, NPJ, Prachumsri, J, Cheah, PY

“…We found that although compensation was a motivation for participation, this was secondary to it being beneficial to self (health checks; link to health networks; building merit) and others (medical research contribution; altruism). …”

Fracture prediction in rheumatoid arthritis: validation of FRAX with bone mineral density for incident major osteoporotic fractures by Richards, C, Stevens, R, Lix, LM, McCloskey, EV, Johansson, H, Harvey, NC, Kanis, JA, Leslie, WD

“…</p> <p><strong>Methods:</strong> Administrative data from patients receiving BMD testing were linked to the Manitoba Population Health Research Data Repository. …”

Brain markers of cumulative stress response and allostatic load in the ageing Whitehall II cohort by Zsoldos, E

“…</p> <p>This thesis thus provides some empirical support for the concept of allostatic load, linking 'everyday' stress and features of the ageing human brain.…”

Participation and cooperation in global climate governance by Rowan, SS

“…First, state participation in climate institutions is linked to their dissatisfaction. Second, patterns of participation are associated with the ambition of countries’ greenhouse gas mitigation targets in the Paris Agreement. …”

Spontaneous ventricular tachyarrhythmias in β2-adrenoceptor transgenic mice in relation to cardiac interstitial fibrosis by Nguyen, M-N, Kiriazis, H, Ruggiero, D, Gao, X-M, Su, Y, Jian, A, Han, L-P, McMullen, JR, Du, X-J

“…The number of VEBs or VT episodes correlated with age (r = 0.83 and r = 0.73) and the content of total or cross-linked collagen (r = 0.62∼0.66, all P &lt;0.01). While having no effect in younger β2-TG mice, β2-AR blockade reduced the frequency of VTA in old β2-TG mice with more severe fibrosis. …”

How economic crises affect alcohol consumption and alcohol-related health problems: A realist systematic review by de Goeij, MCM, Suhrcke, M, Toffolutti, V, van de Mheen, D, Schoenmakers, TM, Kunst, AE

“…Medical, psychological, social, and economic databases were used to search for peer-reviewed qualitative or quantitative empirical evidence (published January 1, 1990-May 1, 2014) linking economic crises or stressors with alcohol consumption and alcohol-related health problems. …”

Temporal evolution of mechanical properties in PDMS: A comparative study of elastic modulus and relaxation time for storage in air and aqueous environment by Zhang, Y, Adam, C, Rehnstrom, H, Contera, S

“…Polydimethylsiloxane (PDMS) is a soft, biocompatible polymer extensively employed in biomedical research, notable for its tunable mechanical properties achieved through cross-linking. While many studies have assessed the mechanical properties of PDMS utilizing macroscopic and microscopic methods, these analyses are often limited to freshly prepared samples. …”

Global marine flyways identified for long-distance migrating seabirds from tracking data by Davies, T, Guilford, T

“…Generally, the flyways were used bidirectionally, and individuals either followed sections of a flyway, a complete flyway, or their movements linked two or more flyways. Transhemispheric figure-of-eight routes in the Atlantic and Pacific oceans, and a circumnavigation flyway in the Southern Ocean correspond with major wind-driven ocean currents.…”

Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve by DiGregorio, H, Mansoorshahi, S, Carlisle, SG, Tovar Pensa, C, Watts, A, McNeely, C, Sabate-Rotes, A, Yetman, A, Michelena, HI, De Backer, JFA, Mosquera, LM, Bissell, MM, Andreassi, MG, Foffa, I, Hui, DS, Caffarelli, A, Kim, YY, Citro, R, De Marco, M, Tretter, JT, McBride, KL, Body, SC, Milewicz, DM, Prakash, SK

“…This study is aimed to assess the role of rare 22q11.2 CNVs in patients with early-onset BAV (EBAV) and to determine whether these variants are linked to an increased risk of complications. Methods: Whole genome microarray genotyping was conducted on 272 patients with BAV with early onset valve or aortic disease (EBAV) and 272 biological relatives. …”

Elucidating the mechanism of mRNA transport using novel imaging technologies by Stoychev, D

“…I apply this assay to investigate a specific mRNA, <em>shot</em>, previously identified as encoding important protein regulators of synaptic development and linked to neurodevelopmental disorders.…”

Antiquity as authority: Jesus and the patriarchs in the Gospel of John by Van Dyk, SL

“…In each instance, the challenge directed to Jesus is contextually linked with his authority to offer eternal life (John 4:10, 13-14; 8:51-52). …”

Understanding health system responsiveness to public feedback at the sub-national level: Insights from Kilifi County, Kenya by Kagwanja, N, Gilson, L, Tsofa, B, Olivier, J, Leli, H, Molyneux, S

“…HFCs are formal structures with community representation linked to a health facility to support community participation in service provision and health outcomes. …”

Synergetic effects of tank background and food colouration on feeding preferences of seahorse Hippocampus barbouri by Ismail, Syahira, Christianus, Annie, Chen, Cheng-Ann, Kawamura, Gunzo, Lim, Leong-Seng, Abd Halid, Nur Fatihah

Synthesis and characterization of mesoporous expanded graphite modified with PA/H3PO4 for enhanced oil sorption efficiency by Elbidi, Moammar, Mohd Salleh, Mohamad Amran, Gunam Resul, Mohamad Faiz Mukhtar, Rashid, Suraya Abdul

Morphological study and performance deterioration of sustainable lignocellulosic corn fiber biocomposites by AL-Oqla, Faris M., Sapuan, S.M.