Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes by McAllan, Liam, Baranasic, Damir, Villicaña, Sergio, Brown, Scarlett, Zhang, Weihua, Lehne, Benjamin, Adamo, Marco, Jenkinson, Andrew, Elkalaawy, Mohamed, Mohammadi, Borzoueh, Hashemi, Majid, Fernandes, Nadia, Lambie, Nathalie, Williams, Richard, Christiansen, Colette, Yang, Youwen, Zudina, Liudmila, Lagou, Vasiliki, Tan, Sili, Castillo-Fernandez, Juan, King, James W. D., Soong, Richie, Elliott, Paul, Scott, James, Prokopenko, Inga, Cebola, Inês, Loh, Marie, Lenhard, Boris, Batterham, Rachel L., Bell, Jordana T., Chambers, John Campbell, Kooner, Jaspal S., Scott, William R.

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An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study by Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J. M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., Hart, Leen M. 't, van de Wiel, Mark A., Beulens, Joline W. J.

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Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk by Zhu, Yinghan, Maikusa, Norihide, Radua, Joaquim, Sämann, Philipp G., Fusar-Poli, Paolo, Agartz, Ingrid, Andreassen, Ole A., Bachman, Peter, Baeza, Inmaculada, Chen, Xiaogang, Choi, Sunah, Corcoran, Cheryl M., Ebdrup, Bjørn H., Fortea, Adriana, Garani, Ranjini Rg, Glenthøj, Birte Yding, Glenthøj, Louise Birkedal, Haas, Shalaila S., Hamilton, Holly K., Hayes, Rebecca A., He, Ying, Heekeren, Karsten, Kasai, Kiyoto, Katagiri, Naoyuki, Kim, Minah, Kristensen, Tina D., Kwon, Jun Soo, Lawrie, Stephen M., Lebedeva, Irina, Lee, Jimmy, Loewy, Rachel L., Mathalon, Daniel H., McGuire, Philip, Mizrahi, Romina, Mizuno, Masafumi, Møller, Paul, Nemoto, Takahiro, Nordholm, Dorte, Omelchenko, Maria A., Raghava, Jayachandra M., Røssberg, Jan I., Rössler, Wulf, Salisbury, Dean F., Sasabayashi, Daiki, Smigielski, Lukasz, Sugranyes, Gisela, Takahashi, Tsutomu, Tamnes, Christian K., Tang, Jinsong, Theodoridou, Anastasia, Tomyshev, Alexander S., Uhlhaas, Peter J., Værnes, Tor G., van Amelsvoort, Therese A. M. J., Waltz, James A., Westlye, Lars T., Zhou, Juan H., Thompson, Paul M., Hernaus, Dennis, Jalbrzikowski, Maria, Koike, Shinsuke

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Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial by Silk, SE, Kalinga, WF, Salkeld, J, Mtaka, IM, Ahmed, S, Milando, F, Diouf, A, Bundi, CK, Balige, N, Hassan, O, Mkindi, CG, Rwezaula, S, Athumani, T, Mswata, S, Lilolime, NS, Simon, B, Msami, H, Mohamed, M, David, DM, Mohammed, L, Nyaulingo, G, Mwalimu, B, Juma, O, Mwamlima, TG, Sasamalo, IA, Mkumbange, RP, Kamage, JJ, Barrett, JR, King, LDW, Hou, MM, Pulido, D, Carnrot, C, Lawrie, AM, Cowan, RE, Nugent, FL, Roberts, R, Cho, J-S, Long, CA, Nielsen, CM, Miura, K, Draper, SJ, Olotu, AI, Minassian, AM

“…<p><strong>Background:</strong> A blood-stage Plasmodium falciparum malaria vaccine would provide a second line of defence to complement partially effective or waning immunity conferred by the approved pre-erythrocytic vaccines. …”

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer by Palafox, Marta, Monserrat, Laia, Bellet, Meritxell, Villacampa, Guillermo, Gonzalez-Perez, Abel, Oliveira, Mafalda, Brasó-Maristany, Fara, Ibrahimi, Nusaibah, Kannan, Srinivasaraghavan, Mina, Leonardo, Herrera-Abreu, Maria Teresa, Òdena, Andreu, Sánchez-Guixé, Mònica, Capelán, Marta, Azaro, Analía, Bruna, Alejandra, Rodríguez, Olga, Guzmán, Marta, Grueso, Judit, Viaplana, Cristina, Hernández, Javier, Su, Faye, Lin, Kui, Clarke, Robert B., Caldas, Carlos, Arribas, Joaquín, Michiels, Stefan, García-Sanz, Alicia, Turner, Nicholas C., Prat, Aleix, Nuciforo, Paolo, Dienstmann, Rodrigo, Verma, Chandra Shekhar, Lopez-Bigas, Nuria, Scaltriti, Maurizio, Arnedos, Monica, Saura, Cristina, Serra, Violeta

“…Here, we show that p16 overexpression is associated with reduced antitumor activity of CDK4/6 inhibitors in patient-derived xenografts (n = 37) and estrogen receptor-positive breast cancer cell lines, as well as reduced response of early and advanced breast cancer patients to CDK4/6 inhibitors (n = 89). …”
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InAlN/GaN high electron mobility transistors on Si for RF applications by Xing, Weichuan

“…Also, device geometries including gate length, line-to-space ratio of the nanostripchannel and gate-to-source distance have been studied. …”
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Multi-site benchmark classification of major depressive disorder using machine learning on cortical and subcortical measures by Belov, Vladimir, Erwin-Grabner, Tracy, Aghajani, Moji, Aleman, Andre, Amod, Alyssa R., Basgoze, Zeynep, Benedetti, Francesco, Besteher, Bianca, Bülow, Robin, Ching, Christopher R. K., Connolly, Colm G., Cullen, Kathryn, Davey, Christopher G., Dima, Danai, Dols, Annemiek, Evans, Jennifer W., Fu, Cynthia H. Y., Gonul, Ali Saffet, Gotlib, Ian H., Grabe, Hans J., Groenewold, Nynke, Hamilton, J. Paul, Harrison, Ben J., Ho, Tiffany C., Mwangi, Benson, Jaworska, Natalia, Jahanshad, Neda, Klimes-Dougan, Bonnie, Koopowitz, Sheri-Michelle, Lancaster, Thomas, Li, Meng, Linden, David E. J., MacMaster, Frank P., Mehler, David M. A., Melloni, Elisa, Mueller, Bryon A., Ojha, Amar, Oudega, Mardien L., Penninx, Brenda W. J. H., Poletti, Sara, Pomarol-Clotet, Edith, Portella, Maria J., Pozzi, Elena, Reneman, Liesbeth, Sacchet, Matthew D., Sämann, Philipp G., Schrantee, Anouk, Sim, Kang, Soares, Jair C., Stein, Dan J., Thomopoulos, Sophia I., Uyar-Demir, Aslihan, van der Wee, Nic J. A., van der Werff, Steven J. A., Völzke, Henry, Whittle, Sarah, Wittfeld, Katharina, Wright, Margaret J., Wu, Mon-Ju, Yang, Tony T., Zarate, Carlos, Veltman, Dick J., Schmaal, Lianne, Thompson, Paul M., Goya-Maldonado, Roberto

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Microfluidic platform for negative enrichment of circulating tumor cells by Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Khuntontong, Puttachat, Wong, Chee Chung, Wang, Zhiping, Puiu, Poenar Daniel, Soo, Ross, Rahman, Abdur Rub Abdur

“…This negative enrichment method employs upstream immunomagnetic depletion to deplete CD45-positive WBCs followed by a microfabricated filter membrane to perform chemical-free RBC depletion and target cells isolation. Experiments of spiking two cell lines, MCF-7 and NCI-H1975, in the whole blood show an average of >90 % cell recovery over a range of spiked cell numbers. …”
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Towards an optimal and unbiased approach for tumor cell isolation by Sajay, Bhuvanendran Nair Gourikutty, Chang, Chia-Pin, Ahmad, Hamizah, Chung, Wong Chee, Puiu, Poenar Daniel, Rahman, Abdur Rub Abdur

“…This approach achieves an average of >90 % recovery of spiked tumor cells and >99 % total WBC depletion in whole blood across multiple cell lines, in a simple and easy-to-use assay. …”
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Social tags as news event detectors by Chua, Alton Yeow Kuan, Razikin, Khasfariyati, Goh, Dion Hoe-Lian

“…First, the performance of using spikes and bursts to detect news events was found to be comparable. …”
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Investigating the potential of axonopus compressus to phytoremediate molybdenum by Eng, Zhi Xian

“…Mo accumulation in dry tissue of AC peaked in Week 1 and gradually decreased with time. Control AC and pots spiked with more than 20 ppm exhibited stunted growth two weeks after treatment. …”
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An on-nanoparticle rolling-circle amplification platform for ultrasensitive protein detection in biological fluids by Yan, Juan, Song, Shiping, Li, Bing, Zhang, Qingzhi, Huang, Qing, Zhang, Hua, Fan, Chunhai

“…The nanoRCA assay is applicable to the detection of two tumor markers in biological fluids: prostate-specific antigen in spiked sera and interleukin-8 in saliva.…”
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Exposure to Pb-halide perovskite nanoparticles can deliver bioavailable Pb but does not alter endogenous gut microbiota in zebrafish by Patsiou, Danae, del Rio-Cubilledo, Cristina, Catarino, Ana Isabel, Summers, Stephen, Afiq Mohd Fahmi, Boyle, David, Fernandes, Teresa F., Henry, Theodore B.

“…Induction of mt2 and reduction of ala-d expression levels in liver tissues showed Pb bioavailability after 2-d and 4-d dietary exposure to perovskite-spiked feeds. Changes in gut microbiota of adult zebrafish were detected after 14-d exposure to Pb-spiked food, but no changes were detected from perovskite-NP spiked food. …”
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Calcined bone provides a reliable substrate for strontium isotope ratios as shown by an enrichment experiment by Snoeck, C, Lee-Thorp, J, Schulting, R, de Jong, J, Debouge, W, Mattielli, N

“…<p><b>Results</b></p> The strontium isotopic ratios of all samples immersed in the spiked solution were strongly modified showing that significant amounts of strontium had been adsorbed or incorporated. …”

Application of Fourier transform infrared spectroscopy to determine free fatty acid contents in palm olein by Che Man, Y.B., Setiowaty, G.

“…This set was prepared by spiking increasing amounts of oleic acid into a series of palm oleins that covers a wide range of FFA (0.08-1.04%). …”
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Software defined network : user centric network by Lim, Derrick Teck Leong.

“…A test of the application was done by running two continuous pings, one from each host to the other. Then, the path in use was disconnected. …”
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Universality for the largest eigenvalue of sample covariance matrices with general population by Bao, Zhigang, Pan, Guangming, Zhou, Wang

“…Moreover, in the real case, we show that when E is spiked with a fixed number of subcritical spikes, the type 1 Tracy—Widom limit TWi holds for the normalized largest eigenvalue of WN, which extends a result of Féral and Péché in [J. …”
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High Rake Angle Orthogonal Machining of Highly Ordered Pyrolytic Graphite Parallel to the Basal Plane by Jayasena, B., Subbiah, S., Reddy, C. D.

“…Evidence of flat, folded, and rolled structures were found in exfoliated graphite sheets in addition to defects such as two types of kink bands. Multiple spikes in measured cutting forces were seen during machining due to disturbances in tool movement. …”
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Goblet cell differentiation in colorectal cancer by Abdullayeva, G

“…These groups included high, medium, and low MUC2/TFF3-expressing cell lines, cell lines with no/very low MUC2 but high TFF3 expression, and cell lines completely lacking these proteins. …”

Self healable neuromorphic memtransistor elements for decentralized sensory signal processing in robotics by John, Rohit Abraham, Tiwari, Naveen, Muhammad Iszaki Patdillah, Kulkarni, Mohit Rameshchandra, Tiwari, Nidhi, Basu, Joydeep, Bose, Sumon Kumar, Ankit, Yu, Chan Jun, Nirmal, Amoolya, Vishwanath, Sujaya Kumar, Bartolozzi, Chiara, Basu, Arindam, Mathews, Nripan

“…The proposed system comprises self-healable materials and memtransistors as enabling technologies for the implementation of neuromorphic nociceptors, spiking local associative learning and communication. …”
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