In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Mechanistically, anti-proliferative and apoptotic effect of TA and its combination with cisplatin on U2OS cells were suggested to be modulated via JNK1 inhibition, ERK2 activation, and intrinsic apoptotic pathways. The findings suggest the potential inclusion of TA in cisplatin-based chemotherapy for osteosarcoma and warrant further investigation…”
Get full text

Laboratory studies on the mechanical properties of sulphur-based construction material at simulated Martian temperatures by Muhammad Nazrif, Muhammad Nazrif, Md. Noor, Norhazilan, Umar, Sarehati, Ahmad Shah, Mohamad Shazwan, Yahaya, Nordin, Kim, Jang-Ho Jay, Ng, Chiew Teng

“…The 60 % sulphur content is suggested for structural elements built internally whereas the 50 % sulphur content demonstrated a high potential in adapting to the harsh Martian environmental conditions. The findings of this study hoped to act as the initial outlook on how such Martian sulphur-based construction material would react upon fabrication on Mars.…”

Factors Influencing Students Intention to Choose Career of Halal Food Industry in Malaysia using Theory of Planned Behavior by Abu Bakar, Nashirah, Rosbi, Sofian, Haji Hashim, Hydzulkifli, Che Arshad, Noraziah

“…Conclusion: This study supported the hypothesis that indicates there is a positive and significant relationship of Attitude (A), Subjective Norm (SN) and Perceived Behavioral Control (PBC) towards Intention (I). The findings of this study add value to theoretical knowledge of career selection among university students. …”
Get full text

The Effectiveness of Flipped Classroom Strategy on Self-Directed Learning Among Undergraduate Mathematics Students by Mohd Nasir, Mohd Azrin, Alaudin, Ros Idayuwati, Ismail, Suzilah, Mat Ali, Nor A’tikah, Mohd Faudzi, Farah Nadia, Yusuff, Noraini, Mohd Pozi, Muhammad Syafiq

“…Overall, the students found that the flipped classroom strategy is potentially enhancing student’s engagement and performance in mathematics education. The findings have implications for the instructors to implement the flipped classroom strategy for mathematics subjects to acquire better performance among undergraduate students. …”
Get full text

Combating Household Bankruptcy: Developing a New Integrated Financial Education Model for Malaysian (S/O 13585) by Sawandi, Norfaiezah, Abu Bakar, Abu Sufian, Shaari, Hasnah, Amran, Noor Afza, Saad, Ram Al Jaffri

“…These expected positive consequences are in line with the 2011-2020 Financial Sector Plan (Area 8-Empowering Consumers) and the Securities Commission Inventor Education Blue Print. The key findings of the study, first, evidence suggests that the level of financial knowledge/literacy amongst Malaysian is arguably low as less than 50% respondents received high score. …”
Get full text

Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians : 6-year longitudinal study by Chua, Jacqueline, Chee, Miao Li, Chin, Calvin Woon Loong, Tham, Yih Chung, Tan, Nicholas, Lim, Sing Hui, Aung, Tin, Cheng, Ching-Yu, Wong, Tien Yin, Schmetterer, Leopold

“…Given that high IOP is a risk factor for glaucoma, our finding highlights the importance of controlling hypertension in older adults, where hypertension and glaucoma incidences are on a rise.…”
Get full text

Loss of caveolin-1 impairs light flicker-induced neurovascular coupling at the optic nerve head by Loo, Jing Hong, Lee, Ying Shi, Woon, Chang Yi, Yong, Victor H. K., Tan, Bingyao, Schmetterer, Leopold, Chong, Rachel S.

“…However, there was no significant difference in RGC density between Cav-1 KO and wild type mice. These findings highlight the role of Cav-1 in regulating neurovascular coupling and IOP and suggest that the loss of Cav-1 may predispose to vascular dysfunction and decreased RGC signaling in the absence of structural loss. …”
Get full text

Perceived inequality in society may not motivate increased food intake in the absence of personal socioeconomic disadvantage by Cheon, Bobby K., Low, Xenia, Wijaya, Darren Jeffian, Lee, Albert

“…Conclusions: Taken together with prior research on the effects of subjective socioeconomic disadvantage on increased energy intake, these findings suggest that perceptions of inequality in one’s society may be insufficient to stimulate heightened energy intake in the absence of personal socioeconomic disadvantage or inadequacy.…”
Get full text

Endothelial damage arising from high salt hypertension is elucidated by vascular bed systematic profiling by Vinaiphat, Arada, Pazhanchamy, Kalailingam, JebaMercy, Gnanasekaran, Ngan, SoFong Cam, Leow, Melvin Khee-Shing, Ho, Hee Hwa, Gao, Yong-Gui, Lim, Kah-Leong, Richards, A. Mark, de Kleijn, Dominique P. V., Chen, Christopher P., Kalaria, Raj N., Liu, Jian, O'Leary, Deborah D., McCarthy, Neil E., Sze, Siu Kwan

“…Consequently, HS-induced hypertensive mice also displayed reduced vascular integrity of multiple organs including lungs, kidneys, and heart. Conclusions: These findings provide novel molecular insight into HS-induced structural changes in eGC and EC composition that may increase cardiovascular risk and potentially guide the development of new diagnostics and therapeutic interventions.…”
Get full text

The identification of significant features towards travel mode choice and its prediction via optimised random forest classifier : An evaluation for active commuting behavior by Nur Fahriza, Mohd Ali, Ahmad Farhan, Mohd Sadullah, P.P. Abdul Majeed, Anwar, Mohd Azraai, Mohd Razman, Musa, Rabiu Muazu

“…Conclusions: The study has illustrated the efficacy of the optimised RF in predicting travel mode choice as well as identified the significant factors for the selection. The findings of the present study provide significant insight for policymakers to improve the performance of the public transportation system so that the users will benefit in terms of health and well-being from active commuting.…”
Get full text
Get full text

Increased consumption of unsaturated fatty acids improves body composition in a hypercholesterolemic Chinese population by Haldar, Sumanto, Ponnalagu, Shalini, Osman, Farhana, Tay, Shia Lyn, Wong, Long Hui, Jiang, Yuan Rong, Leow, Melvin Khee-Shing, Henry, Christiani Jeyakumar

“…Long-term studies are needed to confirm findings. This study had been registered on clinicaltrials.gov (Identifier No.: NCT03964857, https://www.clinicaltrials.gov/ct2/show/NCT03964857).…”
Get full text

A promising deep learning-assistive algorithm for histopathological screening of colorectal cancer by Ho, Cowan, Zhao, Zitong, Chen, Xiu Fen, Sauer, Jan, Saraf, Sahil Ajit, Jialdasani, Rajasa, Taghipour, Kaveh, Sathe, Aneesh, Khor, Li-Yan, Lim, Kiat-Hon, Leow, Wei-Qiang

“…We further trained the composite AI-model's performance on a larger cohort of 105 resections WSIs and then validated our findings on a cohort of 150 biopsies WSIs against the classifications of two independently blinded pathologists. …”
Get full text

Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…Investigations using patient-derived lymphoblastoid cell line carrying heterozygous RAD51C L134S variant showed an impairment in RAD51 chromatin association and replication fork protection, suggestive of deleteriousness of this VUS variant. Overall, our findings provide more insights into molecular roles of RAD51C in replication fork integrity maintenance and in DSB repair.…”
Get full text

Space weather radiation effects on geostationary satellite solid-state power amplifiers by Lohmeyer, W. Q., Cahoy, K. L.

“…By contrast, a Monte Carlo simulation finds that on average, only 2.8 out of 21 (13%) of randomly assigned anomalies occur between 7 and 14days after an electron flux greater than 1.5 standard deviations above the mean. …”
Get full text

Use of functional magnetic resonance imaging to identify cortical loci for lower limb movements and their efficacy for individuals after stroke by Choi, Minseok, Kim, Hyun-Chul, Youn, Inchan, Lee, Song Joo, Lee, Jong-Hwan

“…Conclusions The cortical loci associated with lower limb movements in the PCL identified in healthy participants were validated using independent groups of healthy participants and individuals after stroke. Our findings suggest that these cortical loci may be beneficial for the neurorehabilitation of lower limb movement in individuals after stroke, such as in developing effective rehabilitation interventions guided by the LI scores obtained for neuronal activations calculated from the identified cortical loci across the paretic and non-paretic sides of the brain.…”
Get full text

Patient and Health Care Worker Perceptions of Communication and Ability to Identify Emotion When Wearing Standard and Transparent Masks by Chu, Jacqueline N., Collins, Joy E., Chen, Tina T., Chai, Peter R., Dadabhoy, Farah, Byrne, James D., Wentworth, Adam, DeAndrea-Lazarus, Ian A., Moreland, Christopher J., Wilson, Jaime A. B., Booth, Alicia, Ghenand, Omkar, Hur, Chin, Traverso, Giovanni

“…CONCLUSIONS AND RELEVANCE: The findings of this study suggest that transparent masks could help improve communication during the COVID-19 pandemic, particularly for individuals who are deaf and hard of hearing.…”
Get full text

Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…This combination was the only non-genotoxic conditioning approach that enabled robust donor engraftment post HSCT in WT mice. Conclusion These findings shed new insights into the mechanism of αCD117 mAb-mediated HSC depletion. …”
Get full text

Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…Sulfur–arene interactions appear to tune the reactivity of methionine residues in a manner consistent with rates of oxidation. These findings highlight an underappreciated role for methionine—to protect catalytic histidine residues—and indicate a means by which ptRNases remain functional in oxidatively challenging physiological environments. …”
Get full text
Get full text

Boon or bane? : The role of filial piety, relationship quality, caregiver gender on work-family interface among working caregivers of the elderly by Leong, Anthony Xueheng

“…This is the first study to examine the relationship between the multi-dimensional filial piety and the work-family interface among working caregivers of the elderly, with considerations of relationship quality and gender. Findings point to potential directions for future research and offer suggestions on how to aid working caregivers to optimize interactions between work and family domains. …”
Get full text

Metal-organic architectures driven by a multifunctional 6-aminouracil spacer : structures, noncovalent interactions, and conductivity by Purkayastha, Atanu, Dhar, Sourab, Mondal, Suvra Prakash, Franconetti, Antonio, Frontera, Antonio, Ganguly, Rakesh, Kirillov, Alexander M., Misra, Tarun Kumar

“…The computational study for molecular electrostatic potential (MEP) surface energies revealed an important finding, namely a decrease of the π-acidity of the uracil ring upon coordination and a consequent increase of the π-basicity of the phenyl-sulfonate ring, resulting in effective anti-parallel π–π stacking interactions in 1 and 2. …”
Get full text