Liposomal encapsulation of pro-NO donor drug by Koh, Cheryl Jie Yan

“…Liposomes are utilised as drug carrier due to its biocompatibility and inert nature in the physiological body, to protect the drug as well as prevent premature elimination by the body. …”
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Assignment optimization of pandemic influenza antiviral drugs in Urban pharmacies by Zhang, Chijun, Du, Zhanwei, Cai, Qing, Yu, Limin, Li, Zhaohui, Bai, Yuan

“…Antiviral drugs have benefited public health officers to elucidate outbreak risks by controlling influenza pandemics efficacious, especially effective in the early stage of epidemic outbreaks. …”
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Dynamic drug combination methods for suppressing bacterial antibiotics resistance adaptation by Bhone, Myint Kyaw

“…It is resistant to many drugs and the glycopeptide vancomycin is the only available antibiotic that is active against MRSA infections. …”
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Near-infrared light for phototherapy : photothermal induced drug release and tumor ablation by Li, Menghuan

“…The lessons learnt from the dual responsive core/shell drug nanocarrier proved substantial, which offered useful insights for the shaping of a new NIR responsive drug delivery system. …”
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Glass box and black box machine learning approaches to exploit compositional descriptors of molecules in drug discovery and aid the medicinal chemist by Robson, B, Cooper, R

“…The synthetic medicinal chemist plays a vital role in drug discovery. Today there are AI tools to guide next syntheses, but many are “Black Boxes” (BB). …”

Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…The subsequent study using such clickable MVs as controlled drug/gene delivery vehicles is still in progress.…”
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Modular Titratable Polypills for Personalized Medicine and Simplification of Complex Medication Regimens by Karavasili, Christina, Babaee, Sahab, Kutty, Shruti, Chu, Jacqueline N., Min, Seokkee, Fitzgerald, Nina, Morimoto, Joshua, Inverardi, Nicoletta, Traverso, Giovanni

“…To fill the existing gap in drug dose personalization and simplification of complex medication regimens commonly encountered in the treatment of cardiovascular disease, tuberculosis, and tapering of corticosteroid therapy, a modular titratable polypill approach that simultaneously addresses both aspects is proposed. …”
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Interfacial phenomena and biological recognition of mammalian cells on biomimetic materials by Chan, Vincent.

“…We intend to fill this gap by interrogating the biophysical events involved in membrane-polymer interaction, biological adhesion, tissue engineering and cellular fluid mechanics. …”
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Developing a hollow fiber infection model system to determine the PK/PD of conjugated oligoelectrolytes against clinically relevant pathogens by Wang, Ruolan

“…Therefore, there is a pressing need for the development of novel drugs. One of the key stages in the drug discovery pipeline is understanding the pharmacokinetic/pharmacodynamic (PK/PD) of the new drug. …”
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Surface modified polymers for controlled macroscopic functions by Chng, S

“…A library of polymers with variation in end group, and with expansion of substrate scope, was characterised in detail for chemical and macroscopic properties. In particular, drug delivery properties were investigated using hole-plate bioassays and HPLC-MS methods, and it was found that the antibiotic, Penicillin V, was still active after being loaded onto the polymer scaffolds, with surface modified polymers binding and releasing more drug than the corresponding controls. …”

Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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Smart Microfluidic Devices for Point-Of-Care Applications by Julee Choudhary, Birendra Kumar, Durai, Sundararajan Ananiah, Ahmad, Nabihah

“…Microfluidics is an emerging technology vital in the bio-medical sector, encompassing LabOn-Chip (LOC), drug delivery, maladies diagnostic, and various healthcare fields. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In the second part, I have examined the molecular events underlying drug-induced adaptation, the process by which drug exposure inadvertently drives upregulation of pro-survival signaling pathways. …”
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NMR structure and activity relationship of defensin-analogous peptides by Bai, Yang

“…Despite intensive research, detailed bactericidal and cytotoxic mechanisms of AMPs are still largely unknown. In this thesis, molecular template evolution based on the peptide sequence modifications, biophysical studies using fluorescence labeling and NMR spectroscopy, virtual screening utilizing large scale molecular dynamics simulations are exploited for rational antimicrobial drug discovery. …”
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Identification of novel therapeutic candidates to treat autoimmune diseases by Lim, Eugene Hui Kiat

“…However, the mechanism of interactions is still unclear, and is a potential area for future research of this field.…”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…The function of the NPC1 protein still remains poorly understood and how the NPC1 or NPC2 proteins interact, or the functions of the pathways they regulate still remains unknown. …”

The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…Despite the advent of many new targeted cancer therapies, radiotherapy is still considered an important treatment modality in killing localised cancer cells. …”
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Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Prediction of the next pandemic strain is still a major challenge as mechanisms of antigenic shift and the zoonotic nature of influenza viruses are still poorly understood. …”
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