Cellular thermal shift assay for the identification of drug-target interactions in the Plasmodium falciparum proteome by Dziekan, Jerzy Michal, Wirjanata, Grennady, Dai, Lingyun, Go, Ka Diam, Yu, Han, Lim, Yan Ting, Chen, Liyan, Wang, Loo Chien, Puspita, Brenda, Prabhu, Nayana, Sobota, Radoslaw M., Nordlund, Pär, Bozdech, Zbynek

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Application of variational graph encoders as an effective generalist algorithm in computer-aided drug design by Lam, Hilbert Yuen In, Pincket, Robbe, Han, Hao, Ong, Xing Er, Wang, Zechen, Hinks, Jamie, Wei, Yanjie, Li, Weifeng, Zheng, Liangzhen, Mu, Yuguang

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Immunoprofiling of drug-resistant epilepsy with a focus on glutamic acid decarboxylase 65 antibodies by McGinty, R

“…<p>The urgent need to improve therapies for people with drug-resistant epilepsy (DRE) requires improved understanding of the aetiopathophysiology of epilepsy and the mechanisms responsible for pharmacoresistance. …”

MAS.714J / STS.445J Technologies for Creative Learning, Fall 2004 by Resnick, Mitchel

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Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…‘Rule of 5’, there has been extensive research on lead-like compounds other than those in the realm of small molecule drug-likeness. With this borne in mind Chapter 1, Antimicrobial Peptides – a New Chasm, introduces the concept of protein-protein interactions (PPIs), which could pave the way for development of promising therapeutic agents of various properties such as pacidamycin and muraymycin which are all peptide-based antibiotics that are concerned with PPIs. …”

Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Furthermore, these compounds were then subjected to molecular dynamic simulation, principle component analysis, and MMGBSA using the AMBER20 software, and the results showed stable complexes compared to the control complex. All things considered, this study will help the scientific community and society find a novel drug to treat LC.…”
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Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

16.01-04 Unified Engineering I, II, III, & IV, Fall 2003-Spring 2004 by Hall, Steven Ray, Coleman, Charles P, Drela, Mark, Lundqvist, Ingrid Kristina, Spearing, S Mark, Waitz, Ian A, Young, Peter W

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Inhalable biomimetic nanomotor for pulmonary thrombus therapy by Zhang, Kai, Long, Yuying, Li, Shuting, Zhao, Yanli, Han, Heyou

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Early detection of reduced artemisinin susceptibility in plasmodium falciparum using novel phenotypic indicators by Xiong, Aoli

“…Currently the most widely used methods for the detection of artemisinin resistance include parasites clearance rate measurements, the ring-stage survival assay (RSA) and DNA based approaches to detect mutations in the K13-propeller gene. All these tests are limited in their usefulness for a rapid and accurate diagnosis due to their intrinsic disadvantages: clearance rate is measured post-treatment; RSA is time-consuming and labor-intensive; test for existing K13 mutations is not only time consuming but may also miss new resistance-conferring mutations. …”
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Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…We summarize the essential principles and utility of large simple RCTs, likely applicable to all interventions but especially in order to promote their wider adoption to evaluate new medical devices.…”

Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery by Zhang, Fengying, Ngoc, Nguyen Thi Quynh, Tay, Bao Hui, Mendyk, Aleksander, Shao, Yu-Hsuan, Lau, Raymond

“…The XRD and DSC results indicate that after immersing spray-dried mannitol/LB Agar microparticles in hexane, β-mannitol was completely transformed to α-mannitol in 1 h, and all the δ-mannitol was transformed to α form after 14 days. …”
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The rise and fall of ‘girlsdrinkdiaries.com’: Dilemmas and opportunities when creating online forums to investigate health behaviour by Stepney, M

Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst by Du, Quanchao, Wu, Xiangyang, Bi, Wuguo, Xing, Bengang, Yeow, Edwin Kok Lee

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Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs by Liu, Xili, Moscvin, Maria, Oh, Seungeun, Chen, Tianzeng, Choi, Wonshik, Evans, Benjamin, Rowell, Sean M., Nadeem, Omar, Mo, Clifton C., Sperling, Adam S., Anderson, Kenneth C., Yaqoob, Zahid, Bianchi, Giada, Sung, Yongjin

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Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction by Chen, Xinsong, Sifakis, Emmanouil G., Robertson, Stephanie, Neo, Shi Yong, Jun, Seong-Hwan, Tong, Le, Tay, Apple Hui Min, Lövrot, John, Hellgren, Roxanna, Margolin, Sara, Bergh, Jonas, Foukakis, Theodoros, Lagergren, Jens, Lundqvist, Andreas, Ma, Ran, Hartman, Johan

“…Here, we report that the whole-tumor cell culture (WTC) ex vivo model could be stably established from all breast tumors with a high success rate (98 out of 116), and it could reassemble the parental tumors with the endogenous microenvironment. …”
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Evaluation of paper spray mass spectrometry for direct analysis of small molecule drugs and hemoglobin constant spring peptide markers by Takyi-Williams, John

“…The test compound, sunitinib, was stable in all conditions studied and analyte extraction and detection sensitivity could be improved with sufficient off-line or on-line pre-moistening of the dried spot prior to PS-MS analysis after longer storage period. …”
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Spatially controlled molecular encapsulation in natural pine pollen microcapsules by Prabhakar, Arun Kumar, Potroz, Michael G., Park, Soohyun, Miyako, Eijiro, Cho, Nam-Joon

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Amorphous ternary nanoparticle complex of curcumin-chitosan-hypromellose exhibiting built-in solubility enhancement and physical stability of curcumin by Wong, Jerome Jie Long, Lim, Li Ming, Tran, The-Thien, Wang, Danping, Cheow, Wean Sin, Hadinoto, Kunn

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Liddat oso can by Tng, Adeline Wen Ting

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