Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications by Chen, Xiao, Li, Hua, Lam, King-Yeung

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Gender-based multi-aspect sentiment detection using multilabel learning by Kumar, J. Ashok, Trueman, Tina Esther, Cambria, Erik

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Mitochondrial dysfunction in Down Syndrome: from pathology to therapy by Tan, Kai-Leng, Lee, Han-Chung, Cheah, Pike-See, Ling, King-Hwa

“…Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various vital functions in eukaryotic cells, especially in energy production, calcium homeostasis and programmed cell death. …”
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Real‐time imaging of dynamic cell reprogramming with nanosensors by Wiraja, Christian, Yeo, David Chenloong, Tham, Khek-Chian, Chew, Sharon Wan Ting, Lim, Xinhong, Xu, Chenjie

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Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers by Wang, Liulin, Kabir H. Biswas, Yoon, Bo Kyeong, Kawakami, Lisa M., Park, Soohyun, Groves, Jay T., Li, Lin, Huang, Wei, Cho, Nam-Joon

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Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

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Does everyone have the potential to achieve their ideal body weight? Lay theories about body weight and support for price discrimination policies by Li, Kevin Shaobo, Kokkoris, Michail D., Savani, Krishna

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Effect of metabolite and temperature on artificial human sweat characteristics over a very wide frequency range (400 MHz–10.4 GHz) for wireless hydration diagnostic sensors by Lubangakene, Innocent, Virdee, Bal Singh, Jayanthi, Renu, Ganguly, Priyanka

“…As a result, analysis of electrolytes in this biofluid is gaining traction in the development of non-invasive sweat diagnostics to determine level of dehydration, cystic fibrosis and illicit drugs. This paper presents a wireless measurement modality of permittivity properties of sweat of different metabolite concentration levels exemplifying the full spectrum of human sweat. …”
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Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Naemiratch, B, Kulpijit, N, Ruangkajorn, S, Day, NPJ, Prachumsri, J, Cheah, PY

“…Methods: This paper drew from ethics and social science qualitative study called MIST-ETHICS embedded within the MIST studies. …”

Compressible hollow microlasers in organoids for high-throughput and real-time mechanical screening by Fang, Guocheng, Ho, Beatrice Xuan, Xu, Hongmei, Gong, Chaoyang, Qiao, Zhen, Liao, Yikai, Zhu, Song, Lu, Hongxu, Nie, Ningyuan, Zhou, Tian, Kim, Munho, Huang, Changjin, Soh, Boon Seng, Chen, Yu-Cheng

“…Here, we introduce biocompatible and compressible hollow microlasers that realize all-optical assessment of cellular stress within organoids. …”
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Integrated analysis of the Plasmodium species transcriptome by Hoo, Regina, Zhu, Lei, Amaladoss, Anburaj, Mok, Sachel, Natalang, Onguma, Lapp, Stacey A., Hu, Guangan, Liew, Kingsley, Galinski, Mary R., Bozdech, Zbynek, Preiser, Peter Rainer

“…However, comparative genomics on its own cannot fully explain all the species-specific differences which suggests that other genomic aspects such as regulation of gene expression play an important role in defining species-specific characteristics. …”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Specific siRNA-mediated MnSOD knockdown reversed all three phenotypes. Our findings therefore suggest that MnSOD plays an important integrative role in supporting cancer cell survival in circulation, metastasis, and doxorubicin resistance. …”
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Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…In addition to kinases, we examined the therapeutic potential of the FDA-approved hypertension drug, losartan. Losartan ameliorated the acidic store Ca²⁺ defect, which characterizes NPC, and all downstream pathologies as well as in combination with miglustat reduced levels of neuroinflammation in the mouse model. …”

Polymeric composites for powder-based additive manufacturing : materials and applications by Yuan, Shangqin, Shen, Fei, Chua, Chee Kai, Zhou, Kun

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1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity by Yang, Xuan, Wedajo, Wassihun, Yamada, Yoshiyuki, Dahlroth, Sue-Li, Neo, Jason Jun-Long, Dick, Thomas, Chui, Wai-Keung

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Real-time nanoplasmonic sensing of three-dimensional morphological changes in a supported lipid bilayer and antimicrobial testing applications by Yoon, Bo Kyeong, Park, Hyeonjin, Zhdanov, Vladimir P., Jackman, Joshua A., Cho, Nam-Joon

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Rapid construction of green nanopesticide delivery systems using sophorolipids as surfactants by flash nanoprecipitation by Ma, Enguang, Chen, Kai, Sun, Liang, Fu, Zhinan, Guo, Jiangtao, Liu, Jichang, Zhao, Jigang, Liu, Zhiyong, Lei, Zhigang, Li, Li, Hu, Xiao, Guo, Xuhong

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The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions by Ahmed, Syed Moiz, Ragunathan, Priya, Shin, Joon, Peter, Sabrina, Kleissle, Sabrina, Neuenschwander, Martin, Schäfer, Reinhold, Kries, Jens Peter V., Grüber, Gerhard, Dröge, Peter

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Revealing the biotoxicity of phosphorene oxide nanosheets based on the villin headpiece by Zhang, Wei, Gou, Yuanyuan, Cheng, Li, Dong, Kaiwei, Sheng, Yijie, Ye, Chao, Yang, Xianqing, Mu, Yuguang

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