All the Islands the Island: the crafting of Cortázar's 'La isla a mediodía' by Moran, DP

“…This essay aims to achieve a better understanding of how Julio Cortázar came to write one of his most iconic stories, ‘La isla a mediodía’, as and when he did by identifying the various literary sources on which he may have drawn, including D. H. Lawrence’s story ‘The Man Who Loved Islands’, various works by Aldous Huxley, and, above all, William Golding’s novel Pincher Martin. …”

Plastic Instability in Co-Cr-Ni-Mo alloy wires drawn with different drawing practices by GVK, Sai Srikanth, Tan, Ming Jen, Liu, Zhenyun

Get full text

‘When I open it, I have to drink it all’: push and pull factors shaping domestic alcohol consumption during the COVID-19 pandemic UK Spring 2020 lockdown by Conroy, Dom, Nicholls, Emily

Get full text

Deep graph contrastive learning model for drug-drug interaction prediction by Jiang, Zhenyu, Gong, Zhi, Dai, Xiaopeng, Zhang, Hongyan, Ding, Pingjian, Shen, Cong

“…Drug-drug interaction (DDI) is the combined effects of multiple drugs taken together, which can either enhance or reduce each other's efficacy. …”
Get full text

Development of Attention-based Prediction Models for All-cause Mortality, Home Care Need, and Nursing Home Admission in Ageing Adults in Spain Using Longitudinal Electronic Health... by Carrasco-Ribelles, LA, Cabrera-Bean, M, Khalid, S, Roso-Llorach, A, Violán, C

“…In this study, we developed deep-learning-based prognostic models to predict 1-year and 5-year all-cause mortality, nursing home admission, and home care need in people over 65 years old using all the longitudinal information from EHRs. …”

Triggered drug release and enhanced drug transport from ultrasound-responsive nanoparticles by Kwan, JJ, Coussios, CC

“…Conventional systemic drug therapy across all drug classes does not adequately provide safe and efficacious treatment for a broad range of fatal diseases. …”

Towards Health Centered Drug Policy: An Analysis of Past and Developing Drug Policy by Lewis, Benjamin B.

“…Drug criminalization has disproportionately impacted communities of color and has insufficiently addressed substance use disorder and its associated risk of death through overdosing. …”
Get full text

A bilayer swellable drug-eluting ureteric stent : localized drug delivery to treat urothelial diseases by Lim, Wei Shan, Chen, Kenneth, Chong, Tsung Wen, Xiong, Gordon Minru, Birch, William R., Pan, Jisheng, Lee, Bae Hoon, Er, Pei Shan, Salvekar, Abhijit Vijay, Venkatraman, Subbu S., Huang, Yingying

Get full text
Get full text

Assessing the permeability of supersaturating drug delivery system of amorphous drug-polyelectrolyte/protein nanoplexes in Caco-2 cell monolayer by Tran, The-Thien, Cheow, Wean Sin, Chua, Angeline, Yang, Guang, Poenar, Daniel Puiu, Hadinoto, Kunn

Get full text

Targeting the cytochrome oxidases for drug development in mycobacteria by Lee, Bei Shi, Sviriaeva, Ekaterina, Pethe, Kevin

Get full text

18F-labelling of new chemotypes for drug discovery by Khotavivattana, T

“…Finally, Chapter 5 gives full experimental procedures and characterisation data for all compounds.</p>…”

Amplifying signals in the tumor microenvironment for drug development and diagnostics by Martin Alonso, Maria Carmen

“…Leveraging advancements in high throughput screening and in deep learning, we contribute important tools for the effective design of conditional drugs that require the cleavage of a protease substrate to unleash drug cytotoxicity. …”
Get full text
Get full text

Exploring TNFi drug-levels and anti-drug antibodies during tapering among patients with inflammatory arthritis: secondary analyses from the randomised BIODOPT trial by Uhrenholt, L, Sørensen, MER, Lauridsen, KB, Duch, K, Dreyer, L, Christensen, R, Hauge, E-M, Loft, AG, Rasch, MNB, Horn, HC, Taylor, PC, Nielsen, KR, Kristensen, S

“…ADAb were detected in eight patients, all from the tapering group. TNFi drug-level category or ADAb were not predictive for achieving successful tapering at 18 months. …”

Toxicity, permeability and drug-metabolizing enzyme activities of curcumin analogues by Yakubu, Ndatsu

“…The results of the apparent permeability coefficient (Papp) in Caco-2 cells after 120 min incubation and their absorption (uptake) rates in adult male zebrafish after 4 hr suggested that MS65>BDMC33>EF-24>curcumin. The activities of drug-metabolizing enzymes (CPR,UGT, GST and SULT) in cells and adult male zebrafish subjected to all test compounds, separately, as compared to that of normal cells and zebrafish demonstrated that MS65 is better than BDMC33, followed by EF-24 and then curcumin. …”
Get full text

Assignment optimization of pandemic influenza antiviral drugs in Urban pharmacies by Zhang, Chijun, Du, Zhanwei, Cai, Qing, Yu, Limin, Li, Zhaohui, Bai, Yuan

Get full text

Liposomal carrier systems for encapsulation of drugs using bicellar mixtures by Lee, Bao Jun

“…Drug delivery systems can be in the form of particles in which the drug is protected by a core material that is biocompatible with the body. …”
Get full text

Adverse health events associated with antipsychotic use: an umbrella review by Chow, RTS

Expediting treatments in the 21st century: orphan drugs and accelerated approvals by Domike, Reuben, Raju, G. K., Sullivan, Jamie, Kennedy, Annie

“…In 1983, the United States Congress passed the Orphan Drug Act to provide financial incentives for development of drugs for rare diseases. …”
Get full text

Novel drug-eluting stent to reduce fibrosis-induced ureteral stricture by Fong, Timothy Ren Zhong

“…The aim of this project is to synthesize a drug loaded coating with smooth morphology and identify the effect of thickness, drug loading and pH on the sustained release of MMC. …”
Get full text

Temporal pressure enhanced topical drug delivery through micropore formation by Lio, Daniel Chin Shiuan, Chia, Ruining, Kwek, Milton Sheng Yi, Wiraja, Christian, Madden, Leigh Edward, Chang, Hao, S. Mohideen Abdul Khadir, Wang, Xiaomeng, Becker, David Lawrence, Xu, Chenjie

“…However, existing platforms require high doses of chemical enhancers or sophisticated equipment, use fragile biomolecules, or are limited to a certain type of drug. Here, we report an innovative methodology based on temporal pressure to enhance the penetration of all kinds of drugs, from small molecules to proteins and nanoparticles (up to 500 nm). …”
Get full text