Treatment of acute sore throat in Malaysia: a consensus of multidisciplinary recommendations using modified Delphi methodology by Abdullah, Baharudin, Koh, Kar Chai, Mohamed, Mohazmi, Tan, Vincent Eng Soon, Mohammad, Nurashikin, Sekawi, Zamberi, Periyasamy, Petrick, Ramadas, Anitha, Duerden, Martin

“…A consensus was reached if at least 70% of the group agreed with the statement. Results: All 10 statements for managing acute sore throat achieved consensus. …”
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Small but prospective: development of enzyme-responsive small molecule fluorescent probes for specific bacterial imaging by Yan, Evelias Hui Xin

“…Owing to the evolving pathogenicity of bacteria, whereby more drug-resistant bacteria has been emerging and bacteria developing their own defense mechanism, traditional antimicrobial approaches like antibiotics treatment have been clinically ineffective. …”
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Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models by Muhammad Amali, Abubakar

“…Therefore, may serve as a lead in drug discovery for diabetic wound healing.…”
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Structure and subunit arrangement of Mycobacterial F1FO ATP synthase and novel features of the unique mycobacterial subunit δ by Kamariah, Neelagandan, Huber, Roland G., Nartey, Wilson, Bhushan, Shashi, Bond, Peter J., Grüber, Gerhard

“…The arrangement of δ relative to the N-termini of the catalytic α3β3-headpiece and its potential as a drug target are discussed.…”
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Gametocyte carriage in uncomplicated plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual pat... by Abdulla, S, Achan, J, Yeka, A, D'Alessandro, U, Adam, I, Alemayehu, B, Allan, R, Temu, E, Allen, E, Barnes, K, Anvikar, A, Valecha, N, Arinaitwe, E, Ashley, E, Carrara, V, McGready, R, Nosten, F, Lee, S, White, N, Asih, P, Awab, G, Dondorp, A, Fanello, C, Woodrow, C, Dahal, P, Guerin, P, Humphreys, G, Moreira, C, Nsanzabana, C, Price, R, Sibley, C, Stepniewska, K, Bassat, Q, Gonzalez, R, Baudin, E, Checchi, F, Espie, E, Grandesso, F, Nabasumba, C, Schramm, B, Björkman, A, Bompart, F, Lameyre, V, Bonnet, M, Borrmann, S, Bousema, T, Cenci, F, Cot, M, Faucher, J, Kapulu, M, Marsh, K, Mayxay, M, Newton, P, Roper, C, Deloron, P, Djimde, A, Fofana, B, Doumbo, O, Sagara, I, Dorsey, G, Rosenthal, P, Drakeley, C

“…The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. …”

Organic solvent-assisted control of hydrogel structures and properties by Zhou, Quan

“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. However, major limitations still exist for hydrogels, especially their mechanical weakness, which limits their use in load-bearing applications. …”
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Cryo-electron microscopy structure of the Mycobacterium tuberculosis cytochrome bcc:aa₃ supercomplex and a novel inhibitor targeting subunit cytochrome cI by Mathiyazakan, Vikneswaran, Wong, Chui Fann, Harikishore, Amaravadhi, Pethe, Kevin, Grüber, Gerhard

“…Thus, the bcc:aa3 complex represents a valid drug target for Mycobacterium tuberculosis infections. …”
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Renal-clearable molecular probe for near-infrared fluorescence imaging and urinalysis of SARS-CoV-2 by Liew, Si Si, Zeng, Ziling, Cheng, Penghui, He, Shasha, Zhang, Chi, Pu, Kanyi

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White-light-responsive prussian blue nanophotonic particles for effective eradication of bacteria and improved healing of infected cutaneous wounds by Chakraborty, Nayanika, Jha, Diksha, Singh, Vijay Pal, Kumar, Pradeep, Verma, Navin Kumar, Gautam, Hemant Kumar, Roy, Indrajit

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Single-molecule diagnostics to support curative interventions for tuberculosis and HIV by Dougan, Tyler J.

“…HIV can be treated with lifelong medication. But if drug resistance develops or treatment is interrupted, the virus resurges. …”
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Genomic insights into Vibrio cholerae O1 responsible for cholera epidemics in Tanzania between 1993 and 2017 by Hounmanou, Yaovi Mahuton Gildas, Leekitcharoenphon, Pimlapas, Kudirkiene, Egle, Mdegela, Robinson H., Hendriksen, Rene S., Olsen, John Elmerdahl, Dalsgaard, Anders

“…The strains were less drug resistant with approximate 10-kb deletions found in the SXT element, which encodes resistance to sulfamethoxazole and trimethoprim. …”
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An observational study of the prevalence of metabolic syndrome in treatment-experienced people living with HIV in Singapore by Ang, Li Wei, Ng, Oon Tek, Boudville, Irving Charles, Leo, Yee Sin, Wong, Chen Seong

“…The most common metabolic abnormality among PLHIV was HDL hypocholesterolemia (60.2%) followed by hypertriglyceridemia (45.5%). Of all the 2,231 individuals, 68.8% had at least one component of MetS. …”
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Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng

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Detection of florfenicol resistance in opportunistic Acinetobacter spp. infections in rural Thailand by Tan, Bernice Siu Yan, Mohan, Lalit, Watthanaworawit, Wanitda, Ngamprasertchai, Thundon, Nosten, Francois H., Ling, Clare, Bifani, Pablo

“…Whole genome sequencing was carried out for all the samples collected. Speciation and genome annotation was performed revealing the presence of the floR gene in the bacterial genome. …”
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Malaria parasite stress tolerance is regulated by DNMT2-mediated tRNA cytosine methylation by Hammam, Elie, Sinha, Ameya, Baumgarten, Sebastian, Nardella, Flore, Liang, Jiaqi, Miled, Samia, Bonhomme, Frédéric, Erdmann, Diane, Arcangioli, Benoit, Arimondo, Paola B., Dedon, Peter, Preiser, Peter, Scherf, Artur

“…Our findings give insight into a novel molecular mechanism that regulates P. falciparum response to drug treatment and sexual commitment.…”
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The effect of regularly dosed paracetamol versus no paracetamol on renal function in Plasmodium knowlesi malaria (PACKNOW) : study protocol for a randomised controlled trial by Cooper, Daniel J., Plewes, Katherine, Grigg, Matthew J., Rajahram, Giri S., Piera, Kim A., William, Timothy, Chatfield, Mark D., Yeo, Tsin Wen, Dondorp, Arjen M., Anstey, Nicholas M., Barber, Bridget E.

“…The inexpensive and widely available drug paracetamol inhibits CFHb-induced lipid peroxidation via reduction of ferryl haem to the less toxic Fe3+ state, and has been shown to reduce oxidative damage and improve renal function in patients with sepsis complicated by haemolysis as well as in falciparum malaria. …”
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Pathogen diversity and antimicrobial resistance transmission of Salmonella enterica serovars Typhi and Paratyphi A in Bangladesh, Nepal, and Malawi: a genomic epidemiological study... by Dyson, ZA, Ashton, PM, Khanam, F, Chunga Chirambo, A, Shakya, M, Meiring, JE, Tonks, S, Karkey, A, Msefula, C, Clemens, JD, Dunstan, SJ, Baker, S, Dougan, G, Pitzer, VE, Basnyat, B, Qadri, F, Heyderman, RS, Gordon, MA, Holt, KE, Pollard, AJ, STRATAA Study Group

“…S Typhi genotype 4.3.1 (H58) was common in all sites, but with different dominant variants (4.3.1.1.EA1 in Blantyre, 4.3.1.1 in Dhaka, and 4.3.1.2 in Kathmandu). …”

Chitosan nanofibrous scaffold with graded and controlled release of ciprofloxacin and BMP-2 nanoparticles for the conception of bone regeneration by Zhang, Sihan, Zhao, Guanglei, Mahotra, Manish, Ma, Shiyuan, Li, Wenrui, Lee, Hiang Wee, Yu, Hong, Sampathkumar, Kaarunya, Xie, Denghui, Guo, Jinshan, Loo, Joachim Say Chye

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Evaluating the rediscovery process as a treatment programme for a range of substance use disorders by Parker, Phil

“…No effect on outcomes was seen in the different referral routes for all analysed measures, at all time points, with the exception of impulsivity at 1month and QOL at 3-month. …”
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Metformin degradation with combined Ozone/UV/H2O2 process by Fujinami, Shoko Carissa

“…Metformin is a commonly used drug to treat Type 2 diabetic patients. As the number of diabetic patients globally has increased from 108 million in 1980 to 422 million in 2014, it can be seen that diabetes is a common form of illness and in Singapore, there is about 1 in 10 people suffering from diabetes (Lai, 2015). …”
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