Niemann-Pick type c disease: pathogenesis and therapy by Colaco, A

“…The function of the NPC1 protein still remains poorly understood and how the NPC1 or NPC2 proteins interact, or the functions of the pathways they regulate still remains unknown. …”

The study of radiotherapy resistance of hypoxic tumour for improving survival of cancer patient. by Goh, Yeek Teck.

“…Despite the advent of many new targeted cancer therapies, radiotherapy is still considered an important treatment modality in killing localised cancer cells. …”
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Hybrid, nanoscale phospholipid/block copolymer vesicles by Lim, Seng Koon, Hoog, Hans-Peter de, Nallani, Madhavan, Bo, Liedberg, Parikh, Atul N.

“…In brief, these hybrids may provide alternative tools for drug delivery purposes and molecular imaging/sensing applications and clearly open up new avenues for further investigation.…”
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Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy by Hu, Benhui, Berkey, Christopher, Feliciano, Timothy, Chen, Xiaohong, Li, Zhuyun, Chen, Chao, Amini, Shahrouz, Nai, Mui Hoon, Lei, Qun-Li, Ni, Ran, Wang, Juan, Leow, Wan Ru, Pan, Shaowu, Li, Yong-Qiang, Cai, Pingqiang, Miserez, Ali, Li, Shuzhou, Lim, Chwee Teck, Wu, Yun-Long, Odom, Teri W., Dauskardt, Reinhold H., Chen, Xiaodong

“…Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. …”
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Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…Two antibodies, aducanumab and lecanemab, have been approved by the U.S. Food and Drug Administration, while a third, donanemab, is under review. …”
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Computational analysis for infectious diseases surveillance and host-pathogen interactions (in the context of Influenza A viruses) by Beyene, Biruhalem Taye

“…Prediction of the next pandemic strain is still a major challenge as mechanisms of antigenic shift and the zoonotic nature of influenza viruses are still poorly understood. …”
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Indirect effects of the COVID-19 pandemic: A cause-of-death analysis of life expectancy changes in 24 countries, 2015 to 2022 by Polizzi, A, Zhang, L, Timonin, S, Gupta, A, Dowd, JB, Leon, DA, Aburto, JM

“…By 2022, life expectancy had still not returned to prepandemic levels in several countries. …”

Current trends in additive manufacturing of selective laser melting for biomedical implant applications by Nazari, Aufa Adlia, Hassan, Mohamad Zaki, Ismail, Zarini, Ramlie, Faizir, Jamaludin, Khairur Rijal, Md. Daud, Mohd. Yusof, Ren, James

“…However, high Young's modulus, superior mechanical characteristic, lack of surface integration, high corrosions, failed bone remodeling, and antibacterial performance are still incomparable to be used in anatomical structure. …”
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Supported Lipid Bilayer Platform To Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation by Yorulmaz, Saziye, Jackman, Joshua Alexander, Hunziker, Walter, Cho, Nam-Joon

“…On the other hand, clusterin directly interacts with C5b-7 such that C5b-7 is still able to bind to the lipid bilayer, and clusterin affects the subsequent binding of other complement proteins involved in the MAC assembly. …”
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Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…DPCs repair is critical for maintaining genome stability, however, the knowledge of the DPC repair pathways is still limited. SPRTN, a DNA-dependent metalloprotease, has been identified as the major protease in repairing DPCs. …”

Black hole binary formation and mergers in supermassive black hole discs by Rowan, C

“…</p>0 <p>In summary, the AGN channel remains an important mechanism for BH mergers, in particular for high mass BHs, with much work still to be done to further constrain its observational features.…”

SemFunSim : a new method for measuring disease similarity by integrating semantic and gene functional association by Cheng, Liang, Li, Jie, Ju, Peng, Peng, Jiajie, Wang, Yadong

“…This indicates that SemFunSim is an effective method for drug repositioning.…”
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NIR-light-intensified hypoxic microenvironment for cascaded supra-prodrug activation and synergistic chemo/photodynamic cancer therapy by Chen, Hongzhong, Sun, Tao, Zeng, Weiwei, Zeng, Xiaowei, Mei, Lin, Jiang, Chen, Zhao, Yanli

“…Despite that photodynamic therapy (PDT) has promising clinical prospect, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). …”
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Organic solvent-assisted control of hydrogel structures and properties by Zhou, Quan

“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. However, major limitations still exist for hydrogels, especially their mechanical weakness, which limits their use in load-bearing applications. …”
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Optimizing OOD Detection in Molecular Graphs: A Novel Approach with Diffusion Models by Shen, Xu, Wang, Yili, Zhou, Kaixiong, Pan, Shirui, Wang, Xin

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Detection of florfenicol resistance in opportunistic Acinetobacter spp. infections in rural Thailand by Tan, Bernice Siu Yan, Mohan, Lalit, Watthanaworawit, Wanitda, Ngamprasertchai, Thundon, Nosten, Francois H., Ling, Clare, Bifani, Pablo

“…Ff shares cross-resistance with chloramphenicol, which is still in use in several countries. Furthermore, by selecting for floR-resistance genes, we may be selecting for and facilitating the zoonotic and reverse zoonotic exchange of other flanking resistance markers between human and animal pathogens or commensals with detrimental public health consequences.…”
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Quality of life and healthcare service utilization among methadone maintenance patients in a mountainous area of Northern Vietnam by Nguyen, Long Hoang, Nguyen, Lan Huong Thi, Boggiano, Victoria L., Hoang, Canh Dinh, Van Nguyen, Hung, Le, Huong Thi, Le, Hai Quan, Tran, Tho Dinh, Tran, Bach Xuan, Latkin, Carl A., Zary, Nabil, Vu, Minh Thuc Thi

“…Background: The expansion of methadone maintenance treatment in mountainous areas in still limited and little is known about its health impacts on drug users. …”
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Layer-by-Layer Nanoparticles for Cytokine Delivery by Pires, Ivan S.

“…We also find that the LbL film conformation is key to maintaining therapeutic efficacy as thicker films hinder IL-12 delivery. …”
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Synthesis and characterization of silver nanoprism-based nanostructures by Mohammad Mehdi Shahjamali

“…The Ag@Au structure has still single crystalline nature and can have sharp tips depend on the particle's initial morphology. …”
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Low-power processors for implantable epileptic seizure detection system by Baihaqi, Muhammad Rayhan

“…Despite several treatments are available to suppress the seizure such as anti-epileptic drugs and surgery, around 25% of the epileptic patients still experiences the seizure. …”
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