Dynamic actuation enhances transport and extends therapeutic lifespan in an implantable drug delivery platform by Whyte, William, Goswami, Debkalpa, Wang, Sophie X., Fan, Yiling, Ward, Niamh A., Levey, Ruth E., Beatty, Rachel, Robinson, Scott T., Sheppard, Declan, O’Connor, Raymond, Monahan, David S., Trask, Lesley, Mendez, Keegan L., Varela, Claudia E., Horvath, Markus A., Wylie, Robert, O’Dwyer, Joanne, Domingo-Lopez, Daniel A., Rothman, Arielle S., Duffy, Garry P., Dolan, Eimear B., Roche, Ellen T.

“…Firstly, daily intermittent actuation (cycling at 1 Hz for 5 minutes every 12 hours) preserves long-term, rapid delivery of a model drug (insulin) over 8 weeks of implantation, by mediating local immunomodulation of the cellular FBR and inducing multiphasic temporal FC changes. …”
Get full text

Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”

Investigating novel drug delivery systems to enhance tissue regeneration in the central nervous system by Lin, Vincent Po Hen

Get full text

Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…Furthermore, by BROMO<em>scan</em> the PDCs demonstrated 13-fold selectivity for TRIM24 (PHD-BRD) over BRPF1 (BRD). PDC5 demonstrated some cell permeability, despite its peptidomimetic structure, and so was evaluated in proliferation assays. …”

Boronic acid and nitrofuranyl derivatives as potential therapeutics by Dey, AL

“…‘Rule of 5’, there has been extensive research on lead-like compounds other than those in the realm of small molecule drug-likeness. …”

Extensively drug-resistant Klebsiella pneumoniae associated with complicated urinary tract infection in Northern India by Kaza, P, Xavier, BB, Mahindroo, J, Singh, N, Baker, S, Nguyen, TNT, Mavuduru, RS, Mohan, B, Taneja, N

“…Klebsiella pneumoniae (Kp), which is associated with hospital-acquired infections, is extensively drug-resistant (XDR), making treatment difficult. …”

Computational screening of FDA-approved hepatitis c drugs for inhibition of VEGFR2 in liver cancer by Roney, Miah, Issahaku, Abdul Rashid, Tufail, Nasir, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Furthermore, these compounds were then subjected to molecular dynamic simulation, principle component analysis, and MMGBSA using the AMBER20 software, and the results showed stable complexes compared to the control complex. All things considered, this study will help the scientific community and society find a novel drug to treat LC.…”
Get full text

Combined drug delivery and treatment monitoring using a single high frequency ultrasound system by Yildiz, YO, Ruan, J-R, Gray, MD, Bau, L, Mannaris, C, Kiltie, AE, Vojnovic, B, Stride, E, Browning, RJ

“…This study investigates the feasibility of using a single commercial ultrasound imaging transducer operating at 5 MHz for both drug delivery and real-time imaging. …”

Pyrimidino piperazinyl acetamides : innovative class of hybrid acetamide drugs as potent antimicrobial and antimycobacterial agents by Kanagarajan, V., Gopalakrishnan, M.

Get full text
Get full text

A bilayer swellable drug-eluting stent for the treatment of fibrosis-induced ureteral stricture recurrence by Lim, Wei Shan

“…It is hypothesized that a bilayer swellable drug-eluting stent (BSDES) that can co-apt with the urothelium for the localized and sustained delivery of drugs into the diseased section can reduce or eliminate stricture recurrence. …”
Get full text

Synergistic antibacterial effect of Persicaria odorata synthesised silver nanoparticles with antibiotics on drug-resistant bacteria. by Abdul Hadi, Atieya, Nik Malek, Nik Ahmad Nizam, Matmin, Juan, Asraf, Muhammad Hariz, Susanto, Hendra, Mohammad Din, Shahrulnizahana, Shamsuddin, Mustaffa

Waning of specific antibodies against Delta and Omicron variants five months after a third dose of BNT162b2 SARS-CoV-2 vaccine in elderly individuals by Goh, Yun Shan, Rouers, Angeline, Fong, Siew-Wai, Zhuo, Nicole Ziyi, Hor, Pei Xiang, Loh, Chiew Yee, Huang, Yuling, Neo, Vanessa Kexin, Kam, Isaac Kai Jie, Wang, Bei, Ngoh, Eve Zi Xian, Salleh, Siti Nazihah Mohd, Lee, Raphael Tze Chuen, Pada, Surinder, Sun, Louisa Jin, Ong, Desmond Luan Seng, Somani, Jyoti, Lee, Eng Sing, Maurer-Stroh, Sebastian, Wang, Cheng-I., Leo, Yee Sin, Ren, Ee Chee, Lye, David C., Young, Barnaby Edward, Ng, Lisa F. P., Renia, Laurent

Get full text

Inhalable biomimetic nanomotor for pulmonary thrombus therapy by Zhang, Kai, Long, Yuying, Li, Shuting, Zhao, Yanli, Han, Heyou

Get full text

Early detection of reduced artemisinin susceptibility in plasmodium falciparum using novel phenotypic indicators by Xiong, Aoli

“…The changes in eIF2α phosphorylation and DNA damage, appearing shortly after in vitro drug treatment, were successfully detected in malaria parasites, and correlated with artemisinin resistance, demonstrating their potentials in future clinical applications.…”
Get full text
Get full text

Ocular delivery of predatory bacteria with cryomicroneedles against eye infection by Cui, Mingyue, Zheng, Mengjia, Wiraja, Christian, Chew, Sharon Wan Ting, Mishra, Arti, Mayandi, Venkatesh, Lakshminarayanan, Rajamani, Xu, Chenjie

Get full text

Large simple randomized controlled trials—from drugs to medical devices: lessons from recent experience by Buccheri, S, James, S, Mafham, M, Landray, M, Melvin, T, Oldgren, J, Bulbulia, R, Bowman, L, Hoogervorst, LA, de Mheen, PJM, Juni, P, McCulloch, P, Fraser, AG

“…They are considered essential to establish definitive evidence of efficacy and safety for new drugs, and whenever possible they should also be the preferred method for investigating new high-risk medical devices. …”

Roughness-Controlled Self-Assembly of Mannitol/LB Agar Microparticles by Polymorphic Transformation for Pulmonary Drug Delivery by Zhang, Fengying, Ngoc, Nguyen Thi Quynh, Tay, Bao Hui, Mendyk, Aleksander, Shao, Yu-Hsuan, Lau, Raymond

“…SEM images coupled with image analysis software reveal that different surface morphology of the microparticles have different drug adhesion mechanisms. Comparison of ACI results and image analysis of SEM images shows that an increase in the particle surface roughness can increase the fine particle fractions (FPFs) using the rod-covered mannitol microparticles as drug carriers. …”
Get full text
Get full text

Characterization and evaluation of bilayer coating for enhanced localization and sustained drug delivery for fibrosis-induced ureteral stricture by Chin, Jia Wen

“…Ureteral stents of various thickness (20um, 50um, 100um) coating and drug concentrations (2.5%, 5.0%, 7.5%) were fabricated using spraycoating, and in vitro drug release studies were analysed using high-performance liquid chromatography. …”
Get full text

Surface modification of smooth poly (L-lactic acid) films for gelatin immobilization by Li, Hai, Xia, Yun, Wu, Jumiati, He, Qiyuan, Zhou, Xiaozhu, Lu, Gang, Shang, Lei, Boey, Freddy Yin Chiang, Venkatraman, Subbu S., Zhang, Hua

“…Poly(l-lactic acid) (PLLA) is widely used in drug delivery and medical implants. Surface modification of PLLA with functional groups to immobilize gelatin or other extracellular matrix proteins is commonly used to improve its cellular affinity. …”
Get full text
Get full text

Increasing antibiotic activity by rapid bioorthogonal conjugation of drug to resistant bacteria using an upconverted light-activated photocatalyst by Du, Quanchao, Wu, Xiangyang, Bi, Wuguo, Xing, Bengang, Yeow, Edwin Kok Lee

Get full text