Studies towards the synthesis of bioactive natural products and development of new synthetic methods by Khanizeman, Rabi’ah Nisha

“…It has been estimated that more than half of all approved drugs, from the period 1981 to 2014, are either natural products or their derivatives. …”
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Migration of magnetic microparticles through a liquid–liquid interface under an external magnetic field by Mondal, S, Abbasi, N, Tsai, SSH, Griffiths, IM

“…Liquid–liquid interfaces play a pivotal role in various microfluidic processes involving microparticles, including coating, dissolution, controlled release of polyelectrolytes or drugs, and self-assembly processes. In all of these cases, non-invasive techniques to manipulate the microparticle transport are essential. …”

Targeting NAPE-PLD: assessing its potential in the fight against malaria by Goh, Xiu Ling

“…Malaria remains a major global challenge with increasing artemisinin-resistant Plasmodium falciparum. This calls for an increased need for discovering novel ring-stage drug targets. …”
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Compressible hollow microlasers in organoids for high-throughput and real-time mechanical screening by Fang, Guocheng, Ho, Beatrice Xuan, Xu, Hongmei, Gong, Chaoyang, Qiao, Zhen, Liao, Yikai, Zhu, Song, Lu, Hongxu, Nie, Ningyuan, Zhou, Tian, Kim, Munho, Huang, Changjin, Soh, Boon Seng, Chen, Yu-Cheng

“…Here, we introduce biocompatible and compressible hollow microlasers that realize all-optical assessment of cellular stress within organoids. …”
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Self-propelled autonomous Mg/Pt janus micromotor interaction with human cells by Kong, Lei, Chia, Hui Ling, Guan, Jianguo, Pumera, Martin, Nur Farhanah Rosli

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Dearomatization of (hetero)arenes through photodriven interplay between polysulfide anions and formate by Tan, Eugene Yew Kun, Mat Lani, Amirah S, Sow, Wayne, Liu, Yuliang, Li, Haoyu, Chiba, Shunsuke

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Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

“…We have trained a learning models with the aim of complementing genetics-based drug susceptibility testing.</p> <br> <p><strong>Methods:</strong> We built a Test+Train dataset comprising 219 susceptible mutations. …”

Sharing is caring? International Society for Pharmacoepidemiology review and recommendations for sharing programming code by Tazare, J, Wang, SV, Gini, R, Prieto Alhambra, D, Arlett, P, Morales Leaver, DR, Morton, C, Logie, J, Popovic, J, Donegan, K, Schneeweiss, S, Douglas, I, Schultze, A

“…<p><strong> Methods: </p></strong>We conducted a literature review identifying all studies published in Pharmacoepidemiology and Drug Safety (PDS) between 2017 and 2022. …”

Physicochemical and in-vitro release studies of liponanocapsules by Tan, Dulcia Wei Ni.

“…The objective of this project is to optimize and study the formulation of stable polyelectrolyte coated liposomes called liponanocapsules. They are formed using the layer-by-layer (lbl) technique. …”
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G-cleave LC3B biosensor: monitoring autophagy and assessing resveratrol's synergistic impact on doxorubicin-induced apoptosis in breast cancer cells by Liao, C, Long, Y, Tsai, M, Lin, C, Hsu, K, Lee, C

“…Autophagy, a crucial process in cancer, is closely intertwined with both tumor progression and drug resistance development. However, existing methods used to assess autophagy activity often pose invasiveness and time-related constraints, limiting their applicability in preclinical drug investigations. …”

Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

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Structure and function of the smoothened extracellular domain in vertebrate hedgehog signaling by Rohatgi, Rajat, Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Covey, Douglas F, Siebold, Christian, Ingham, Philip William

“…Indeed, targeting of the Smo CRD by oxysterol-inspired small molecules can block signaling by all known classes of Hh activators and by clinically relevant Smo mutants.…”
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Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites by Kumar, Ammu Prasanna, Nguyen, Minh Nhan, Verma, Chandra, Lukman, Suryani

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A multiphysics model of photo-sensitive hydrogels in response to light-thermo-pH-salt coupled stimuli for biomedical applications by Chen, Xiao, Li, Hua, Lam, King-Yeung

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Gender-based multi-aspect sentiment detection using multilabel learning by Kumar, J. Ashok, Trueman, Tina Esther, Cambria, Erik

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Synthesis, biological evaluation, and stability studies of raloxifene mono- and bis-sulfamates as dual-targeting agents by Zaraei, S-O, Dohle, W, Anbar, HS, El-Gamal, R, Leblond, B, Foster, PA, Al-Tel, TH, Potter, BVL, El-Gamal, MI

“…All three possible sulfamate derivatives of the selective estrogen receptor modulator Raloxifene (bis-sulfamate 7 and two mono-sulfamates 8–9) were synthesized and evaluated as inhibitors of the clinical drug target steroid sulfatase (STS), both in cell-free and in cell-based assays, and also as estrogen receptor (ER) modulators. …”

Evaluation of diabetic wound healing properties of moringa oleifera lam using in vitro and in vivo wound models by Muhammad Amali, Abubakar

“…Therefore, may serve as a lead in drug discovery for diabetic wound healing.…”
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Real‐time imaging of dynamic cell reprogramming with nanosensors by Wiraja, Christian, Yeo, David Chenloong, Tham, Khek-Chian, Chew, Sharon Wan Ting, Lim, Xinhong, Xu, Chenjie

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Membrane reconstitution of monoamine oxidase enzymes on supported lipid bilayers by Wang, Liulin, Kabir H. Biswas, Yoon, Bo Kyeong, Kawakami, Lisa M., Park, Soohyun, Groves, Jay T., Li, Lin, Huang, Wei, Cho, Nam-Joon

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Peptide asparaginyl ligases—renegade peptide bond makers by Tam, James P., Chan, Ning-Yu, Liew, Heng Tai, Tan, Shaun J., Chen, Yu

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